The Biology of Aging and the Quality of Later Life

1985 ◽  
pp. 29-49 ◽  
Author(s):  
Kenneth M. Weiss
Keyword(s):  
Later Life ◽  
Biology Of Aging

scholarly journals Physical Resilience as a Determinant of Healthspan and Lifespan in Mice

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 829-829
Author(s):  
Nathan LeBrasseur
Keyword(s):  
Middle Ages ◽  
Interest Group ◽  
Later Life ◽  
Cytotoxic Drugs ◽  
Geriatric Syndromes ◽  
Age Related ◽  
Fundamental Biology ◽  
Dynamic Measures ◽  
Biology Of Aging ◽  
Insight Into

Abstract Dynamic measures of physical resilience—the ability to resist and recover from a challenge—may be informative of biological age far prior to overt manifestations such as age-related diseases and geriatric syndromes (i.e., frailty). If true, physical resilience at younger or middle ages may be predictive of future healthspan and lifespan, and provide a unique paradigm in which interventions targeting the fundamental biology of aging can be tested. This seminar will discuss research on the development of clinically-relevant measures of physical resilience in mice, including anesthesia, surgery, and cytotoxic drugs. It will further highlight how these measures compare between young, middle-aged, and older mice, and how mid-life resilience relates to later-life healthspan. Finally, it will provide insight into whether interventions targeting the biology of aging can modify physical resilience in mice. Part of a symposium sponsored by Epidemiology of Aging Interest Group.

scholarly journals Pain and Hardship Among Older Men: Examining the Buffering Effect of Medicare Insurance Coverage

2018 ◽  
Vol 12 (5) ◽  
pp. 1439-1449 ◽  
Author(s):  
Gillian L. Marshall ◽  
Tamara A. Baker ◽  
Chiho Song ◽  
David B. Miller
Keyword(s):  
Insurance Coverage ◽  
Interactive Effect ◽  
Later Life ◽  
Older Men ◽  
The United States ◽  
Pain Severity ◽  
Financial Strain ◽  
Cross Sectional ◽  
Retirement Study

To better understand the health status of men in the United States, this study aimed to assess the association of hardship on the presence of and pain severity among men 50 years of age and older. Cross-sectional multivariate logistic regression analyses were conducted using the 2010 wave of the Health and Retirement Study ( N = 3,174) to assess the association between four hardship indicators and the presence of pain and pain severity among this sample of older men. Results suggest that the association between the presence of pain and hardship was statistically significant across all four indicators: ongoing financial hardship (CI [1.05, 1.63], p < .05), difficulty paying bills (CI [1.42, 3.02], p < .001), food insecurity (CI [1.46, 3.15], p < .001), and not taking medication due to cost (CI [1.06, 1.66], p < .05), even after adjusting for all demographic factors. The associations between pain severity and ongoing financial strain (CI [1.23, 2.83], p < .01) and difficulty paying bills (CI [1.02, 3.18], p < .05) were statistically significant. Results also indicate that education was a buffer at all levels. In addition, the interactive effect of hardship and Medicare insurance coverage on pain severity was significant only for ongoing financial strain (CI [1.74, 14.33], p > .001) and difficulty paying bills (CI [1.26, 7.05], p < .05). The evidence is clear that each hardship indicators is associated with the presence of pain and across some of the indicators in pain severity among men aged 50 and older. In addition, these findings stress the importance that Medicare insurance plays in acting as a buffer to alleviate some of the hardships experienced by older men. These findings also highlight the association between the presence of pain and pain severity for the overall quality of life, health outcomes, and financial position of men in later life.

The Black Elderly: Satisfaction and quality of later life

Physiotherapy ◽  
1996 ◽  
Vol 82 (10) ◽  
pp. 594
Author(s):  
Patricia Odunmbaku Auty
Keyword(s):  
Later Life ◽  
Black Elderly

Childhood Experience and Depression

1969 ◽  
Vol 115 (525) ◽  
pp. 883-888 ◽  
Author(s):  
M. J. Abrahams ◽  
F. A. Whitlock
Keyword(s):  
Mental Illness ◽  
Family Relationships ◽  
Later Life ◽  
Parental Loss ◽  
Emotional Experiences ◽  
Childhood Experience ◽  
The Family ◽  
Childhood Deprivation

The possibility of a relationship between early parental loss and mental illness, suicide, or delinquency in later life is a well-known, although by no means universally accepted, theory. In this investigation, we have attempted to compare patients with carefully matched controls and to investigate, when possible, the various categories of depression separately. Also, as we felt that a study concerned with childhood deprivation based solely on the physical absence of parents would tell us little of the daily emotional experiences of the child, we have attempted to take into account the quality of the family relationships present in childhood.

The ESRC Growing Older research programme, 1999–2004

2004 ◽  
Vol 24 (5) ◽  
pp. 657-674 ◽  
Author(s):  
ALAN WALKER
Keyword(s):  
Quality Of Life ◽  
Social Research ◽  
Research Programme ◽  
Later Life ◽  
Evidence Base ◽  
Active Ageing ◽  
New Knowledge ◽  
Full Capacity ◽  
The Uk

This article introduces the seven specially commissioned papers in this special issue of Ageing & Society from the projects funded by the UK Economic and Social Research Council's Growing Older Programme. The ESRC Programme has been the largest single investment in social sciences research on ageing in the United Kingdom. It comprised 24 projects and, when operating at full capacity, 96 researchers. The article details the background to the Programme, its commissioning process, its eventual structure and how it operated. Then a selection is made of some of the ways in which the Programme has contributed new knowledge to social gerontology. No attempt is made to achieve comprehensive coverage of the Programme's topics but rather a selection is presented of the new insights generated under its six themes: defining and measuring quality of life, inequalities in quality of life, technology and the built environment, healthy and active ageing, family and support networks, and participation and activities in later life. The projects were spread unevenly across these themes but important new knowledge has been produced under each theme. The conclusion emphasises the scientific contribution of the Programme and especially the extent to which older people's own attitudes, aspirations and preferences have been at the forefront, but it questions whether or not policy makers and practitioners will use this major evidence base.

Experience of Time and Subjective Age When Facing a Limited Lifetime: The Case of Older Adults with Advanced Cancer

2021 ◽  
pp. 089826432110631
Author(s):  
Katsiaryna Laryionava ◽  
Anton Schönstein ◽  
Pia Heußner ◽  
Wolfgang Hiddemann ◽  
Eva C. Winkler ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Older Adults ◽  
Advanced Cancer ◽  
Later Life ◽  
Subjective Age ◽  
Perceived Quality Of Life ◽  
Experience Of Time ◽  
Finite Resource ◽  
Life Threatening

Objectives We addressed two questions: (1) Does advanced cancer in later life affect a person’s awareness of time and their subjective age? (2) Are awareness of time and subjective age associated with distress, perceived quality of life, and depression? Methods We assessed patients suffering terminal cancer (OAC, n = 91) and older adults free of any life-threatening disease (OA, n = 89), all subjects being aged 50 years or older. Results Older adults with advanced cancer perceived time more strongly as being a finite resource and felt significantly older than OA controls. Feeling younger was meaningfully related with better quality of life and less distress. In the OA group, feeling younger was also associated to reduced depression. Perceiving time as a finite resource was related to higher quality of life in the OA group. Discussion Major indicators of an older person’s awareness of time and subjective aging differ between those being confronted with advanced cancer versus controls.

Epidemiologic Trends, Social Determinants, and Brain Health: The Role of Life Course Inequalities

Stroke ◽  
2022 ◽  
Author(s):  
Saima Hilal ◽  
Carol Brayne
Keyword(s):  
Life Course ◽  
Healthy Lifestyle ◽  
Later Life ◽  
Functional Independence ◽  
Health Determinants ◽  
Brain Health ◽  
Public Health Challenge ◽  
Specific Disorders

Brain health as expressed in our mental health and occurrence of specific disorders such as dementia and stroke is vitally important to quality of life, functional independence, and risk of institutionalization. Maintaining brain health is, therefore, a societal imperative, and public health challenge, from prevention of acquisition of brain disorders, through protection and risk reduction to supporting those with such disorders through effective societal and system approaches. To identify possible mechanisms that explain the differential effect of potentially modifiable risk factors, and factors that may mitigate risk, a life course approach is needed. This is key to understanding how poor health can accumulate from the earliest life stages. It also allows us to integrate and investigate key material, behavioral, and psychological factors that generate health inequalities within and across communities and societies. This review provides a narrative on how brain health is intimately linked to wider health determinants, thus importance for clinicians and societies alike. There is compelling evidence accumulated from research over decades that socioeconomic status, higher education, and healthy lifestyle extend life and compress major morbidities into later life. Brain health is part of this, but collective action has been limited, partly because of the separation of disciplines and focus on highly reductionist approaches in that clinicians and associated research have focused more on mitigation and early detection of specific diseases. However, clinicians could be part of the drive for better brain health for all society to support life courses that have more protection and less risk. There is evidence of change in such risks for conditions such as stroke and dementia across generations. The evidence points to the importance of starting with parental health and life course inequalities as a central focus.

Spirituality in Later Life: Effect on Quality of Life

2007 ◽  
Vol 33 (1) ◽  
pp. 32-39 ◽  
Author(s):  
Anita E. Molzahn
Keyword(s):  
Quality Of Life ◽  
Later Life
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