scholarly journals Physical Resilience as a Determinant of Healthspan and Lifespan in Mice

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 829-829
Author(s):  
Nathan LeBrasseur
Keyword(s):  
Middle Ages ◽  
Interest Group ◽  
Later Life ◽  
Cytotoxic Drugs ◽  
Geriatric Syndromes ◽  
Age Related ◽  
Fundamental Biology ◽  
Dynamic Measures ◽  
Biology Of Aging ◽  
Insight Into

Abstract Dynamic measures of physical resilience—the ability to resist and recover from a challenge—may be informative of biological age far prior to overt manifestations such as age-related diseases and geriatric syndromes (i.e., frailty). If true, physical resilience at younger or middle ages may be predictive of future healthspan and lifespan, and provide a unique paradigm in which interventions targeting the fundamental biology of aging can be tested. This seminar will discuss research on the development of clinically-relevant measures of physical resilience in mice, including anesthesia, surgery, and cytotoxic drugs. It will further highlight how these measures compare between young, middle-aged, and older mice, and how mid-life resilience relates to later-life healthspan. Finally, it will provide insight into whether interventions targeting the biology of aging can modify physical resilience in mice. Part of a symposium sponsored by Epidemiology of Aging Interest Group.

scholarly journals Resilience as a Determinant of Healthspan and Lifespan in Mice

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 163-163
Author(s):  
Nathan LeBrasseur
Keyword(s):  
Middle Ages ◽  
Later Life ◽  
Cytotoxic Drugs ◽  
Biological Age ◽  
Geriatric Syndromes ◽  
Age Related ◽  
Fundamental Biology ◽  
Dynamic Measures ◽  
Biology Of Aging ◽  
Insight Into

Abstract Dynamic measures of physical resilience—the ability to resist and recover from a challenge—may be informative of biological age far prior to overt manifestations such as age-related diseases and geriatric syndromes (i.e., frailty). If true, physical resilience at younger or middle ages may be predictive of future healthspan and lifespan, and provide a unique paradigm in which interventions targeting the fundamental biology of aging can be tested. This seminar will discuss research on the development of clinically relevant measures of physical resilience in mice, including anesthesia, surgery, and cytotoxic drugs. It will further highlight how these measures compare between young, middle-aged, and older mice, and how mid-life resilience relates to later-life healthspan and even lifespan. Finally, it will provide insight into whether interventions targeting the biology of aging can modify physical resilience in mice.

scholarly journals A Biomarker-based Biological Age in UK Biobank: Composition and Prediction of Mortality and Hospital Admissions

2021 ◽  
Author(s):  
Mei Sum Chan ◽  
Matthew Arnold ◽  
Alison Offer ◽  
Imen Hammami ◽  
Marion Mafham ◽  
...  
Keyword(s):  
Principal Components ◽  
Hospital Admissions ◽  
Later Life ◽  
Chronological Age ◽  
Uk Biobank ◽  
Hand Grip ◽  
Cox Proportional Hazard ◽  
Prediction Of Mortality ◽  
Age Related ◽  
Cox Proportional Hazard Models

Abstract Background Chronological age is the strongest risk factor for most chronic diseases. Developing a biomarker-based age and understanding its most important contributing biomarkers may shed light on the effects of age on later-life health and inform opportunities for disease prevention. Methods A subpopulation of 141 254 individuals healthy at baseline were studied, from among 480 019 UK Biobank participants aged 40–70 recruited in 2006–2010, and followed up for 6–12 years via linked death and secondary care records. Principal components of 72 biomarkers measured at baseline were characterized and used to construct sex-specific composite biomarker ages using the Klemera Doubal method, which derived a weighted sum of biomarker principal components based on their linear associations with chronological age. Biomarker importance in the biomarker ages was assessed by the proportion of the variation in the biomarker ages that each explained. The proportions of the overall biomarker and chronological age effects on mortality and age-related hospital admissions explained by the biomarker ages were compared using likelihoods in Cox proportional hazard models. Results Reduced lung function, kidney function, reaction time, insulin-like growth factor 1, hand grip strength, and higher blood pressure were key contributors to the derived biomarker age in both men and women. The biomarker ages accounted for >65% and >84% of the apparent effect of age on mortality and hospital admissions for the healthy and whole populations, respectively, and significantly improved prediction of mortality (p < .001) and hospital admissions (p < 1 × 10−10) over chronological age alone. Conclusions This study suggests that a broader, multisystem approach to research and prevention of diseases of aging warrants consideration.

scholarly journals Sexuality in Later Life and Mental Health Among Older Black Gay Men

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 313-314
Author(s):  
Darlingtina Esiaka ◽  
Alice Cheng ◽  
Candidus Nwakasi
Keyword(s):  
Mental Health ◽  
Gay Men ◽  
Later Life ◽  
The United States ◽  
Mental Wellbeing ◽  
Self Identity ◽  
Sexual Identities ◽  
Age Related ◽  
Wide Range ◽  
Black Gay Men

Abstract Self-acknowledgement and integration of racial and sexual identities are significant to one’s overall sense of identity because of their implications for mental health and wellbeing. These issues are important as one ages because older people experience a wide range of factors that add layers to their ability to (re)integrate subsets of their identity into their overall self-identity such as age and age-related disabilities. This study examined the intersection of race and sexual identities on overall health status in older Black gay men, a demographic group that has historically received less attention. Data from the Social Justice Sexuality (SJS) survey of LGBTQ+ people of color which occurred over a 12-month period in the United States were analyzed. Participants (N=160), 50 years and over, responded to questions about their sexuality, social identity, family dynamics, community connection and engagement, and mental and physical health. Results show an association of mental wellbeing with racial and sexual identities. Further, results show that a strong sense of connection to other sexual minorities is positively associated with mental health in older Black gay men. We discuss the implication of findings for mental health interventions targeting this gendered population.

scholarly journals The Impact of Bone on the Biology of Aging

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 740-740
Author(s):  
Gerard Karsenty
Keyword(s):  
Muscle Function ◽  
Male Fertility ◽  
Leydig Cells ◽  
Memory Loss ◽  
Age Related ◽  
Systematic Exploration ◽  
Biology Of Aging ◽  
The Impact ◽  
The Brain ◽  
Regulate Energy Metabolism

Abstract We hypothesized that bone may secrete hormones that regulate energy metabolism and reproduction. Testing this hypothesis revealed that the osteoblast-specific secreted protein osteocalcin is a hormone regulating glucose homeostasis and male fertility by signaling through a GPCR, Gprc6a, expressed in pancreatic β bells and Leydig cells of the testes. The systematic exploration of osteocalcin biology, revealed that it regulates an unexpectedly large spectrum of physiological functions in the brain and peripheral organs and that it has most features of an antigeromic molecule. As will be presented at the meeting, this body of work suggests that harnessing osteocalcin for therapeutic purposes may be beneficial in the treatment of age-related diseases such as depression, age-related memory loss and the decline in muscle function seen in sarcopenia.

scholarly journals Targeting Senescent Cells to Counter Aging and Aging-Related Conditions

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 818-818
Author(s):  
Nathan LeBrasseur
Keyword(s):  
Human Populations ◽  
Geriatric Syndromes ◽  
Preclinical Models ◽  
Pharmacological Agents ◽  
New Class ◽  
Age Related ◽  
Selective Elimination ◽  
Early Phase Clinical Trials ◽  
And Function ◽  
State Of The Science

Abstract In response to various forms of age-associated damage, cells can enter a state of senescence. Senescent cells can compromise the health and function of a tissue, and their accumulation with advancing age is believed to contribute to age-related diseases and geriatric syndromes. In preclinical models (i.e., mice), selective elimination of senescent cells through either genetic approaches or a new class of pharmacological agents, termed “senolytics”, has been show to effectively delay, prevent, or reverse the onset and/or progression of pulmonary disease, osteoporosis, atherosclerosis, diabetes, cognitive decline, and several other conditions. Thus, considerable efforts are underway to optimize pharmacological strategies and test their effectiveness in human populations. This seminar will highlight the state-of-the-science of senolytic drugs, and the opportunities and challenges for early phase clinical trials in humans.

scholarly journals Identification of Relevant Sociocognitive Determinants Explaining Multiple Parental Sun Protection Behaviors

2021 ◽  
pp. 109019812110104
Author(s):  
Karlijn Thoonen ◽  
Liesbeth van Osch ◽  
Rik Crutzen ◽  
Hein de Vries ◽  
Francine Schneider
Keyword(s):  
Skin Cancer ◽  
Self Efficacy ◽  
Sun Exposure ◽  
Later Life ◽  
Sun Protection ◽  
Survey Study ◽  
Skin Cancer Prevention ◽  
Sun Safety ◽  
And Behaviors ◽  
Insight Into

Background Adequate sun safety during childhood is crucial for decreasing skin cancer risk in later life. Although parents are an essential target group in applying sun protection measures for their children, insight into the determinants associated with their sun protection behaviors is limited. Aims This study aims to identify the most relevant determinants in predicting multiple parental sun protection intentions and behaviors in different sun exposure situations. Method A longitudinal survey study with two measurements was conducted among Dutch parents ( N = 670) of children (4–12 years old). Twenty-seven sociocognitive determinants were examined in terms of relevance regarding four parental sun protection behaviors in different sun exposure situations. The Confidence Interval-Based Estimation of Relevance approach was used to visualize room for improvement (sample means) on all determinants and their association strengths (correlations) with sun protection intentions and behaviors. Results Behavior-specific rather than generic determinants were most relevant in explaining all sun protection behaviors. Of these determinants, attitude, self-efficacy and action planning, and especially parental feelings of difficulty in performing sun protection behaviors, were most relevant. Altogether, the explained variance of all sociocognitive determinants was highest for shade-seeking behavior ( R2 = .41 and .43) and lowest for supportive behavior ( R2 = .19 and .29) in both planned and incidental sun exposure situations, respectively. Discussion This study provides detailed insight into relevant sociocognitive determinants of parental sun protection behaviors in various sun exposure situations and directions for composing parental skin cancer prevention interventions. Conclusions Future composition of sun safety interventions should emphasize on enhancing parental feelings of self-efficacy, especially for shade-seeking and clothing behaviors.

scholarly journals Developing a recovery-focused therapy for older people with bipolar disorder: a qualitative focus group study

BMJ Open ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. e049829
Author(s):  
Elizabeth Tyler ◽  
Fiona Lobban ◽  
Rita Long ◽  
Steven H Jones
Keyword(s):  
Older Adults ◽  
Bipolar Disorder ◽  
Focus Group ◽  
Older People ◽  
Focus Groups ◽  
Later Life ◽  
Focus Group Study ◽  
Age Related ◽  
Health Related ◽  
Age Related Changes

ObjectivesAs awareness of bipolar disorder (BD) increases and the world experiences a rapid ageing of the population, the number of people living with BD in later life is expected to rise substantially. There is no current evidence base for the effectiveness of psychological interventions for older adults with BD. This focus group study explored a number of topics to inform the development and delivery of a recovery-focused therapy (RfT) for older adults with BD.DesignA qualitative focus group study.SettingThree focus groups were conducted at a university in the North West of England.ParticipantsEight people took part in the focus groups; six older adults with BD, one carer and one friend.ResultsParticipant’s responses clustered into six themes: (1) health-related and age-related changes in later life, (2) the experience of BD in later life, (3) managing and coping with BD in later life, (4) recovery in later life, (5) seeking helping in the future and (6) adapting RfT for older people.ConclusionsParticipants reported a range of health-related and age-related changes and strategies to manage their BD. Participants held mixed views about using the term ‘recovery’ in later life. Participants were in agreement that certain adaptations were needed for delivering RfT for older adults, based on their experience of living with BD in later life. The data collected as part of the focus groups have led to a number of recommendations for delivering RfT for older adults with BD in a randomised controlled trial (Clinical Trial Registration: ISRCTN13875321).

Geriatric Otolaryngology

2021 ◽  
Author(s):  
Christian Caceres ◽  
Kourosh Parham
Keyword(s):  
Obstructive Sleep Apnea ◽  
Hearing Loss ◽  
Sleep Apnea ◽  
Head And Neck ◽  
Malignant Neoplasms ◽  
Geriatric Syndromes ◽  
Healthcare Needs ◽  
Age Related ◽  
Obstructive Sleep ◽  
Age Related Hearing Loss

With increasing life expectancy, the unique healthcare needs of the older patient are being better appreciated. To address these growing needs, which differ from those of the average adult patient, otolaryngologists must acquire new knowledge and competencies. This chapter provides a broad overview of geriatric otolaryngology and highlights subspecialty topics where otolaryngologists are called upon to administer care. These include age-related hearing loss, balance disorders, sinonasal disease, voice and swallowing disorders, obstructive sleep apnea and head and neck cancer. Geriatric concerns in each of these specific areas have to be addressed in the broader context of geriatric syndromes in coordination with geriatricians or other geriatric-trained providers to advance an integrated, team-based approach to maintaining or restoring the older patients’ well-being. This review contains 3 figures, 2 tables and 161 references Keywords: Cognitive decline, delirium, frailty, age-related hearing loss, presbystasis, presbylarynx, immunosenecense, presbynasalis, vasomotor rhinitis, chronic sinusitis, age-related oflactory decline, dysphagia, head and neck malignant neoplasms, obstructive sleep apnea, geriatric syndromes and perioperative optimization.

Two Hiberno-Latin Texts on the Gospels

Traditio ◽  
1959 ◽  
Vol 15 ◽  
pp. 387-401
Author(s):  
Robert E. McNally
Keyword(s):  
Middle Ages ◽  
Latin Literature ◽  
Biblical Exegesis ◽  
Early Middle Ages ◽  
Intellectual Activity ◽  
Isidore Of Seville ◽  
Clear Insight ◽  
Venerable Bede ◽  
Alcuin Of York ◽  
Insight Into

The two texts presented here as a contribution to Hiberno-Latin literature are only a fragment of the still unedited Bible commentaries which came forth from the Irish Bible Schools of the Early Middle Ages. These two pieces are valuable sources for the development of biblical exegesis in the pre-Carolingian age, which, except for the accomplishment of the Venerable Bede (d. 735), is distinguished neither for the richness nor the depth of its theological writing. The years between the death of St. Isidore of Seville (d. 636) and Alcuin of York (d. 804) were dominated by the intellectual activity of the Irish monks, whose reputation for learning was mainly founded on their Bible scholarship. But the fruit of this scholarship is not well known. Though the two texts edited below do not represent all the intellectual factors involved in the biblical exegesis of the ancient schools of Ireland, they do reflect the spirit and method of these schools; and they do afford a clear insight into the cultural problem of the development of medieval exegesis at its earliest stage.

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