Alkylating agent resistance

1989 ◽  
pp. 125-150
Author(s):  
Margie L. Clapper ◽  
Kenneth D. Tew
Keyword(s):  
Alkylating Agent

Alkylating agent prodrugs for ADEPT

1996 ◽  
Vol 22 (3) ◽  
pp. 331-340 ◽  
Author(s):  
P.J. Burke
Keyword(s):  
Alkylating Agent

scholarly journals Ameliorative effect of Allium atroviolaceum on sperm quality in cyclophosphamide-treated mice

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Alireza Hosseini ◽  
Mehrdad Shahrani ◽  
Shirin Asgharian ◽  
Maryam Anjomshoa ◽  
Ayoob Rostamzadeh ◽  
...  
Keyword(s):  
Side Effects ◽  
Alkylating Agent ◽  
Sperm Quality ◽  
Sperm Count ◽  
Reproductive Toxicity ◽  
Herbal Drugs ◽  
Sperm Viability ◽  
Complementary Treatment ◽  
Ameliorative Effect ◽  
Alternative Drugs

Abstract Background Cyclophosphamide (CP) is an anti-neoplastic alkylating agent that is extensively used in different chemotherapy regimens. Adverse effects on the reproductive system, especially spermatogenesis, are one of the most important side effects of this drug. It is medically essential to use complementary and alternative drugs. Herbal drugs have long been used as a complementary treatment. Our purpose was to study the effect of hydroalcoholic Allium atroviolaceum L. extract on spermatogenesis in CP-treated mice. Results CP affected a significant decrease in sperm count, motility, viability, and morphology. Sperm count was significantly higher in the all extract groups than in the group of control (p<0.001) and CP group (p<0.001, p<0.01). Sperm motility was significantly greater in the extract (100 and 200mg/kg) groups than in the group of control (p<0.05 and <0.001). Sperm immotility and rotational movement were significantly higher in the CP group than in the CP+extract groups (p<0.001). The sperm viability was significantly greater in the CP+extract (200mg/kg) group than in the CP group (p<0.001). The number of headless sperm, sperm with initial tail, with coiled tail, and sperm with curved body, was significantly lower in the CP+extract (200mg/kg) group than in the CP group (p<0.001). Conclusion A. atroviolaceum extract treatment significantly improved CP-induced reproductive toxicity.

Synthesis and stability of 1-aminoalkylphosphonic acid quaternary ammonium salts

2021 ◽  
Author(s):  
Tomasz K. Olszewski ◽  
Anna Brol
Keyword(s):  
Phosphonic Acid ◽  
Quaternary Ammonium ◽  
Alkylating Agent ◽  
Quaternary Ammonium Salts ◽  
Ammonium Salts ◽  
Aminoalkylphosphonic Acid

An effective protocol for quaternization of simple 1-aminoalkylphosphonic acids under basic conditions and using Me2SO4 as convenient alkylating agent is reported. In the course of reaction phosphonic acid quaternary ammonium...

scholarly journals Application of Commercially Available Anhydrous Potassium Fluoride for a Convenient Synthesis of Ketene Dithioacetals

1999 ◽  
Vol 23 (8) ◽  
pp. 492-493
Author(s):  
Sabir H. Mashraqui ◽  
Harini Hariharasubrahmanian
Keyword(s):  
Carbon Disulfide ◽  
Alkylating Agent ◽  
Potassium Fluoride ◽  
Solid Support ◽  
Ambient Conditions ◽  
Ketene Dithioacetals ◽  
Convenient Synthesis ◽  
Active Methylene Compounds ◽  
Active Methylene

Commercially available anhydrous KF without activation or solid support promotes condensation between active methylene compounds, carbon disulfide and an alkylating agent in dry DMF to allow the preparation of a variety of ketene dithioacetals in fair to good yields under ambient conditions.

New sterically hindered bis-catechol, bis- o -quinone and its bis-triphenylantimony(v) bis-catecholate. 3,5-Di- tert -butyl-6-methoxymethylcatechol as alkylating agent

2018 ◽  
Vol 28 (1) ◽  
pp. 76-78 ◽  
Author(s):  
Maxim V. Arsenyev ◽  
Tatyana V. Astafeva ◽  
Evgeny V. Baranov ◽  
Andrey I. Poddelsky ◽  
Sergey A. Chesnokov
Keyword(s):  
Alkylating Agent ◽  
Tert Butyl ◽  
Sterically Hindered

scholarly journals The Substrate Analog, Bromopyruvate, as Both a Substrate and Alkylating Agent for 2-Keto-3-deoxy-6-phosphogluconic Aldolase

1972 ◽  
Vol 247 (13) ◽  
pp. 4186-4191
Author(s):  
H. Paul Meloche ◽  
Mark A. Luczak ◽  
James M. Wurster
Keyword(s):  
Alkylating Agent ◽  
Substrate Analog

scholarly journals Chronic senescent human mesenchymal stem cells as possible contributor to the wound healing disorder after exposure to the alkylating agent sulfur mustard

2021 ◽  
Vol 95 (2) ◽  
pp. 727-747
Author(s):  
Simone Rothmiller ◽  
Niklas Jäger ◽  
Nicole Meier ◽  
Thimo Meyer ◽  
Adrian Neu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Mesenchymal Stem Cells ◽  
Alkylating Agent ◽  
Chronic Wounds ◽  
Sulfur Mustard ◽  
Morphological Changes ◽  
Human Mesenchymal Stem Cells ◽  
Age Related

AbstractWound healing is a complex process, and disturbance of even a single mechanism can result in chronic ulcers developing after exposure to the alkylating agent sulfur mustard (SM). A possible contributor may be SM-induced chronic senescent mesenchymal stem cells (MSCs), unable to fulfil their regenerative role, by persisting over long time periods and creating a proinflammatory microenvironment. Here we show that senescence induction in human bone marrow derived MSCs was time- and concentration-dependent, and chronic senescence could be verified 3 weeks after exposure to between 10 and 40 µM SM. Morphological changes, reduced clonogenic and migration potential, longer scratch closure times, differences in senescence, motility and DNA damage response associated genes as well as increased levels of proinflammatory cytokines were revealed. Selective removal of these cells by senolytic drugs, in which ABT-263 showed initial potential in vitro, opens the possibility for an innovative treatment strategy for chronic wounds, but also tumors and age-related diseases.

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