Immunochemical Studies of the Relationship Between the Neuronal Cytoskeleton and Neurofibrillary Tangles

1987 ◽  
pp. 151-163
Author(s):  
D. P. Hue ◽  
J. P. Brion ◽  
P. A. Robinson ◽  
B. H. Anderton
Keyword(s):  
Neurofibrillary Tangles ◽  
Neuronal Cytoskeleton ◽  
The Relationship

The Neuronal Cytoskeleton and Neurofibrillary Tangles

1986 ◽  
pp. 35-52
Author(s):  
B. H. Anderton ◽  
J.-P. Brion ◽  
J. Flament-Durand ◽  
M. C. Haugh ◽  
J. Kahn ◽  
...  
Keyword(s):  
Neurofibrillary Tangles ◽  
Neuronal Cytoskeleton

The relationship between αB-crystallin and neurofibrillary tangles in Alzheimer's disease

2001 ◽  
Vol 27 (3) ◽  
pp. 180-188 ◽  
Author(s):  
J. J. Mao ◽  
S. Katayama ◽  
C. Watanabe ◽  
Y. Harada ◽  
K. Noda ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurofibrillary Tangles ◽  
Αb Crystallin ◽  
The Relationship

Molecular Insight into the Crosstalk of UPS Components and Alzheimer’s Disease

2020 ◽  
Vol 21 (12) ◽  
pp. 1193-1201
Author(s):  
Abdullah Al Mamun ◽  
Md. Mosiqur Rahman ◽  
Sonia Zaman ◽  
Mst Shirajum Munira ◽  
Md. Sahab Uddin ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurofibrillary Tangles ◽  
Early Stage ◽  
Therapeutic Interventions ◽  
Cellular Proteins ◽  
Synaptic Dysfunction ◽  
Main Components ◽  
The Relationship ◽  
Insight Into

: The ubiquitin (Ub)-proteasome system (UPS) targets various cellular proteins for degradation. It has been found that defects in the UPS play a crucial role in the pathogenesis of Alzheimer's disease (AD), as the existence of Ub immunoreactivity in AD-linked neuronal inclusions, including neurofibrillary tangles, is observed in all types of AD cases. Current investigations have shown that components of the UPS can be connected with the early stage of AD, which is characterized by synaptic dysfunction, and to the late phases of the disease, marked by neurodegeneration. Although the significance of UPS in the pathogenesis of AD has been emphasized, targeted treatment at the main components of these pathways has a great perspective in advancing new therapeutic interventions for AD. In this review, we emphasize the relationship between UPS and AD pathology. We also represent the recent therapeutic advancements targeting UPS components in AD.

scholarly journals NDRG2 Expression Correlates with Neurofibrillary Tangles and Microglial Pathology in the Ageing Brain

2020 ◽  
Vol 21 (1) ◽  
pp. 340
Author(s):  
Motaz M. Fadul ◽  
Claire J. Garwood ◽  
Rachel Waller ◽  
Navonna Garrett ◽  
Paul R. Heath ◽  
...  
Keyword(s):  
Neurofibrillary Tangles ◽  
Excitatory Amino Acid ◽  
Temporal Cortex ◽  
Excitatory Amino Acid Transporter ◽  
Damage Response ◽  
Ndrg2 Expression ◽  
Β Amyloid ◽  
The Relationship ◽  
Ageing Brain ◽  
Insight Into

Astrocytes play a major role in the pathogenesis of a range of neurodegenerative diseases, including Alzheimer’s disease (AD), undergoing dramatic morphological and molecular changes that can cause potentially both beneficial and detrimental effects. They comprise a heterogeneous population, requiring a panel of specific phenotype markers to identify astrocyte subtypes, changes in function and their relation to pathology. This study aimed to characterise expression of the astrocyte marker N-myc downstream regulated gene 2 (NDRG2) in the ageing brain, investigate the relationship between NDRG2 and a panel of astrocyte markers, and relate NDRG2 expression to pathology. NDRG2 specifically immunolabelled the cell body and radiating processes of astrocytes in the temporal cortex of the Cognitive Function and Ageing Study (CFAS) neuropathology cohort. Expression of NDRG2 did not correlate with other astrocyte markers, including glial fibrillary acidic protein (GFAP), excitatory amino acid transporter 2 (EAAT2) and glutamine synthetase (GS). NDRG2 showed a relationship to AT8+ neurofibrillary tangles (p = 0.001) and CD68+ microglia (p = 0.047), but not β-amyloid plaques or astrocyte nuclear γH2AX immunoreactivity, a marker of DNA damage response. These findings provide new insight into the astrocyte response to pathology in the ageing brain, and suggest NDRG2 may be a potential target to modulate this response.

The relationship between subcortical tau pathology and Alzheimer's disease

2012 ◽  
Vol 40 (4) ◽  
pp. 711-715 ◽  
Author(s):  
Johannes Attems ◽  
Dietmar R. Thal ◽  
Kurt A. Jellinger
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurofibrillary Tangles ◽  
Neuronal Damage ◽  
The Other ◽  
Tau Pathology ◽  
Subcortical Nuclei ◽  
Ad Alzheimer’S Disease ◽  
The Relationship ◽  
Transentorhinal Region

The stepwise progression of tau pathology [NFTs (neurofibrillary tangles) and NTs (neuropil threads)] in AD (Alzheimer's disease) is generally assumed to begin in the transentorhinal region (entorhinal stage) from which it progresses to the hippocampus (limbic stage) and to neocortical regions (neocortical stage). This stepwise progression is reflected in the NFT Braak stages. However, it has been shown recently that tau pathology is frequently seen in subcortical nuclei, in particular the LC (locus coeruleus) in over 90% of individuals under 30 years of age, suggesting that AD-associated tau pathology begins in the LC and not in the transentorhinal region. On the other hand, only minimal amounts of tau pathology are seen in the LC in cases with considerable entorhinal tau pathology, while the severity of tau pathology in the LC significantly increases with increasing NFT Braak stages. These findings suggest that the LC becomes increasingly involved during AD progression rather than representing the site initially affected. Further studies are warranted to answer the question of whether tau pathology in the LC of young individuals is associated with AD or whether it rather reflects non-specific neuronal damage.

Interstellar gas in the central region of the Galaxy

1967 ◽  
Vol 31 ◽  
pp. 239-251 ◽  
Author(s):  
F. J. Kerr
Keyword(s):  
Central Region ◽  
Galactic Plane ◽  
Neutral Hydrogen ◽  
Continuum Emission ◽  
Galactic Centre ◽  
Interstellar Gas ◽  
Hydrogen Recombination ◽  
The Galaxy ◽  
Centre Region ◽  
The Relationship

A review is given of information on the galactic-centre region obtained from recent observations of the 21-cm line from neutral hydrogen, the 18-cm group of OH lines, a hydrogen recombination line at 6 cm wavelength, and the continuum emission from ionized hydrogen.Both inward and outward motions are important in this region, in addition to rotation. Several types of observation indicate the presence of material in features inclined to the galactic plane. The relationship between the H and OH concentrations is not yet clear, but a rough picture of the central region can be proposed.

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