Prostaglandin Endoperoxide Metabolism by the Human Carotid Artery

Object The purpose of this study was to determine the effectiveness of infrared free-electron laser (FEL) irradiation of cholesterol esters in human carotid artery (CA) atheromas. Methods The degradation of cholesterol ester was estimated from changes in the infrared absorption spectra acquired using microscopic transmission Fourier transform infrared spectroscopy. An FEL emitting radiation at 5.75-μm wavelengths and a power density of 15.9 W/cm2 was used to treat intimal slices of extirpated human arterial atherosclerotic plaques. Peak signals derived from an ester bond of cholesterol ester decreased in height as irradiation time increased and disappeared completely after 180 seconds. No other change was observed in the infrared absorption spectrum after 180 seconds of irradiation, and no histological damage was noted. Conclusions The authors concluded that FEL irradiation can remove cholesterol ester selectively from human atheromatous CA plaques. This novel technique differs from previous approaches involving conventional lasers.

Download Full-text

Measurement of Wall Shear Stress Exerted by Flowing Blood in the Human Carotid Artery: Ultrasound Doppler Velocimetry and Echo Particle Image Velocimetry

Ultrasound in Medicine & Biology ◽

10.1016/j.ultrasmedbio.2018.02.013 ◽

2018 ◽

Vol 44 (7) ◽

pp. 1392-1401 ◽

Cited By ~ 11

Author(s):

Phillip E. Gates ◽

Arati Gurung ◽

Luciano Mazzaro ◽

Kuni Aizawa ◽

Salim Elyas ◽

...

Keyword(s):

Shear Stress ◽

Particle Image Velocimetry ◽

Carotid Artery ◽

Wall Shear Stress ◽

Particle Image ◽

Doppler Velocimetry ◽

Ultrasound Doppler ◽

Image Velocimetry ◽

Flowing Blood ◽

Human Carotid

Download Full-text

In Vitro Three Dimensional Imaging of Human Carotid Atherosclerotic Plaques Using Ultrasonography

ASME 2011 Summer Bioengineering Conference, Parts A and B ◽

10.1115/sbc2011-53463 ◽

2011 ◽

Author(s):

Renate W. Boekhoven ◽

Marcel C. M. Rutten ◽

Marc R. H. M. van Sambeek ◽

Frans N. van de Vosse

Keyword(s):

Mechanical Properties ◽

Carotid Artery ◽

Carotid Endarterectomy ◽

Early Stage ◽

Three Dimensional ◽

Atherosclerotic Plaques ◽

Unstable Plaques ◽

Human Carotid ◽

Selection Of

Ruptured atherosclerotic plaques in the carotid artery are the main cause of stroke (70–80%). To prevent it, carotid endarterectomy is the procedure of choice in patients with a recent symptomatic 70–99% stenosis. Today, the selection of candidates is based on stenosis size only. However, endarterectomy is beneficial for only 1 out of 6 patients [1], the patients with unstable plaques (Fig. 1). Knowledge of mechanical properties of different components in the atherosclerotic arteries is important, because it will allow the identification of plaque stability at an early stage.

Download Full-text

Diagnosis of atherosclerosis in human carotid artery by FT-Raman spectroscopy: Principal Components Analysis algorithm

10.1117/12.530315 ◽

2004 ◽

Author(s):

Grazielle V. Nogueira ◽

Landulfo Silveira, Jr. ◽

Airton A. Martin ◽

Renato A. Zangaro ◽

Marcos T. Pacheco ◽

...

Keyword(s):

Raman Spectroscopy ◽

Carotid Artery ◽

Principal Components Analysis ◽

Principal Components ◽

Analysis Algorithm ◽

Ft Raman Spectroscopy ◽

Components Analysis ◽

Human Carotid ◽

Ft Raman

Download Full-text

Construction of an in vivo carotid siphon model for testing endovascular devices for neuro-interventions

Interventional Neuroradiology ◽

10.1177/1591019916688649 ◽

2017 ◽

Vol 23 (3) ◽

pp. 325-329

Author(s):

Bu-Lang Gao ◽

Yong-Li Wang ◽

Xue-Jing Zhang ◽

Qiong-Ying Fan ◽

Wei-Li Hao ◽

...

Keyword(s):

Carotid Artery ◽

Glass Tube ◽

Covered Stent ◽

Covered Stents ◽

Carotid Siphon ◽

Endovascular Interventions ◽

Pass Through ◽

Endovascular Devices ◽

Human Carotid

Objective The aim of this study was to construct an in vivo carotid siphon model for testing neurovascular devices for endovascular interventions. Methods A model of a human carotid siphon was pre-shaped using a glass tube from a human cadaver and used to confine a segment of one side of the common carotid artery (CCA) in canines. This segment of CCA with the glass carotid siphon on was interposed end-to-end onto the contralateral CCA so as to simulate a human carotid artery siphon in vivo. Two weeks later, the siphon model was evaluated using computed tomography angiography and digital subtraction angiography, and the covered stent specially designed for intracranial vasculature was navigated through the siphon model for a longitudinal flexibility test. Results All dogs tolerated the procedures well, and the artificial siphon model in vivo provided realistic conditions for device testing. Two weeks later, the in vivo carotid siphon model remained patent with no thrombosis. Five covered stents were navigated to pass through five siphon models successfully, with vasospasm occurring in two siphons. Conclusion Construction of an in vivo siphon model in dogs with a glass tube is feasible and useful for the test of endovascular devices for treating neurovascular diseases.

Download Full-text