scholarly journals Erratum to: Early Life Hypoxic or Hypoxic/Hypercapnic Stress Alters Acute Ventilatory Sensitivity in Adult Mice

2018 ◽  
pp. E3-E3
Author(s):  
Kui Xu ◽  
Solomon Raju Bhupanapadu Sunkesula ◽  
Pengjing Huang ◽  
Constantinos P. Tsipis ◽  
Thomas Radford ◽  
...  
Keyword(s):  
Early Life ◽  
Adult Mice

Effects of dietary n-3 PUFA levels in early life on susceptibility to high-fat-diet-induced metabolic syndrome in adult mice

2020 ◽  
pp. 108578
Author(s):  
Dan-Dan Wang ◽  
Fang Wu ◽  
Ling-Yu Zhang ◽  
Ying-Cai Zhao ◽  
Cheng-Cheng Wang ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
High Fat Diet ◽  
Early Life ◽  
High Fat ◽  
Adult Mice

Hippocampal neuroligin-2 links early-life stress with impaired social recognition and increased aggression in adult mice

2015 ◽  
Vol 55 ◽  
pp. 128-143 ◽  
Author(s):  
Christine Kohl ◽  
Xiao-Dong Wang ◽  
Jocelyn Grosse ◽  
Céline Fournier ◽  
Daniela Harbich ◽  
...  
Keyword(s):  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Social Recognition ◽  
Adult Mice

Impacts of early-life paraquat exposure on gut microbiota and body weight in adult mice

Chemosphere ◽  
2021 ◽  
pp. 133135
Author(s):  
Yixi Li ◽  
Zhenzi Zuo ◽  
Bing Zhang ◽  
Huan Luo ◽  
Bo Song ◽  
...  
Keyword(s):  
Body Weight ◽  
Gut Microbiota ◽  
Early Life ◽  
Adult Mice

scholarly journals A murine model of pediatric inflammatory bowel disease causes microbiota-gut-brain axis deficits in adulthood

2020 ◽  
Vol 319 (3) ◽  
pp. G361-G374 ◽  
Author(s):  
Eloisa Salvo ◽  
Patricia Stokes ◽  
Ciara E. Keogh ◽  
Ingrid Brust-Mascher ◽  
Carly Hennessey ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Early Life ◽  
Low Dose ◽  
Behavioral Deficits ◽  
Colonic Inflammation ◽  
Gut Dysbiosis ◽  
Pediatric Inflammatory Bowel Disease ◽  
Adult Mice ◽  
Inflammatory Bowel

Here we describe long-lasting impacts on the microbiota-gut-brain (MGB) axis following administration of low-dose dextran sodium sulfate (DSS) to weaning mice (P21), including gut dysbiosis, colonic inflammation, and brain/behavioral deficits in adulthood (P56). Early-life DSS leads to acute colonic inflammation, similar to adult mice; however, it results in long-lasting deficits in the MGB axis in adulthood (P56), in contrast to the transient deficits seen in adult DSS. This model highlights the unique features of pediatric inflammatory bowel disease.

Brain-resident memory T cells generated early in life predispose to autoimmune disease in mice

2019 ◽  
Vol 11 (498) ◽  
pp. eaav5519 ◽  
Author(s):  
Karin Steinbach ◽  
Ilena Vincenti ◽  
Kristof Egervari ◽  
Mario Kreutzfeldt ◽  
Franziska van der Meer ◽  
...  
Keyword(s):  
T Cells ◽  
Autoimmune Disease ◽  
Early Life ◽  
Viral Infections ◽  
Memory T Cells ◽  
Epidemiological Studies ◽  
Critical Window ◽  
Adult Mice ◽  
Previous Infection ◽  
Resident Memory T Cells

Epidemiological studies associate viral infections during childhood with the risk of developing autoimmune disease during adulthood. However, the mechanistic link between these events remains elusive. We report that transient viral infection of the brain in early life, but not at a later age, precipitates brain autoimmune disease elicited by adoptive transfer of myelin-specific CD4+ T cells at sites of previous infection in adult mice. Early-life infection of mouse brains imprinted a chronic inflammatory signature that consisted of brain-resident memory T cells expressing the chemokine (C-C motif) ligand 5 (CCL5). Blockade of CCL5 signaling via C-C chemokine receptor type 5 prevented the formation of brain lesions in a mouse model of autoimmune disease. In mouse and human brain, CCL5+ TRM were located predominantly to sites of microglial activation. This study uncovers how transient brain viral infections in a critical window in life might leave persisting chemotactic cues and create a long-lived permissive environment for autoimmunity.

The Effect of Early-Life Stress on Airway Inflammation in Adult Mice

2010 ◽  
Vol 17 (4) ◽  
pp. 229-239 ◽  
Author(s):  
Rattanjeet Vig ◽  
John R. Gordon ◽  
Bernard Thébaud ◽  
A. Dean Befus ◽  
Harissios Vliagoftis
Keyword(s):  
Airway Inflammation ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Adult Mice

Early-life status epilepticus induces ectopic granule cells in adult mice dentate gyrus

2008 ◽  
Vol 211 (2) ◽  
pp. 503-510 ◽  
Author(s):  
Rieko Muramatsu ◽  
Yuji Ikegaya ◽  
Norio Matsuki ◽  
Ryuta Koyama
Keyword(s):  
Status Epilepticus ◽  
Dentate Gyrus ◽  
Early Life ◽  
Granule Cells ◽  
Adult Mice
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