Statistical Graphics in Late Stage Drug Development

2012 ◽  
pp. 241-253
Author(s):  
Julia Wang ◽  
Surya Mohanty
Keyword(s):  
Drug Development ◽  
Late Stage ◽  
Statistical Graphics

Sequential C-Selective Difluoromethylation/Pd-Catalyzed Decarboxylative Protonation: An Efficient Access to Tertiary Difluoromethylated Scaffolds

2019 ◽  
Author(s):  
Nicolas Duchemin ◽  
Roberto Buccafusca ◽  
Marc Daumas ◽  
Vincent Ferey ◽  
Stellios Arseniyadis
Keyword(s):  
Drug Development ◽  
Late Stage ◽  
Efficient Access ◽  
Palladium Catalyzed ◽  
General Method

We report here a general method that allows a highly straightforward access to tertiary difluoromethylated compounds. The strategy relies on a two-step sequence featuring a C-selective electrophilic difluoromethylation and an unprecedented palladium-catalyzed decarboxylative protonation. Considering the generality of the method and the attractive properties offered by the difluoromethyl group, this approach provides a valuable tool for late-stage functionalization and drug development.<br>

scholarly journals Improving the assessment of the probability of success in late stage drug development

2021 ◽  
Author(s):  
Lisa V. Hampson ◽  
Björn Bornkamp ◽  
Björn Holzhauer ◽  
Joseph Kahn ◽  
Markus R. Lange ◽  
...  
Keyword(s):  
Drug Development ◽  
Late Stage ◽  
Probability Of Success

scholarly journals in silico ADMET Screening of Compounds Present in Cyanthillium cinereum (L.) H. Rob.

2020 ◽  
Vol 32 (6) ◽  
pp. 1421-1426
Author(s):  
J. Dharani ◽  
S. Ravi
Keyword(s):  
Drug Development ◽  
Late Stage ◽  
In Silico ◽  
Chemical Structure ◽  
Discovery Process ◽  
In Silico Admet

Drug development involves assessment of absorption, distribution, metabolism, excretion and toxicity (ADMET) increasingly earlier in the discovery process. in silico ADMET studies are expected to reduce the risk of late-stage attrition of drug development and to optimize screening and testing by looking at only the promising compounds. To this end, several in silico approaches for predicting ADMET properties of compounds from their chemical structure have been developed, ranging from data-based approaches. In this study, ADMET prediction has been done for 20 compounds from the plant Cyanthillium cinereum extracts. Some of the compounds were predicted to be non-toxic.

Sequential C-Selective Difluoromethylation/Pd-Catalyzed Decarboxylative Protonation: An Efficient Access to Tertiary Difluoromethylated Scaffolds

2019 ◽  
Author(s):  
Nicolas Duchemin ◽  
Roberto Buccafusca ◽  
Marc Daumas ◽  
Vincent Ferey ◽  
Stellios Arseniyadis
Keyword(s):  
Drug Development ◽  
Late Stage ◽  
Efficient Access ◽  
Palladium Catalyzed ◽  
General Method

We report here a general method that allows a highly straightforward access to tertiary difluoromethylated compounds. The strategy relies on a two-step sequence featuring a C-selective electrophilic difluoromethylation and an unprecedented palladium-catalyzed decarboxylative protonation. Considering the generality of the method and the attractive properties offered by the difluoromethyl group, this approach provides a valuable tool for late-stage functionalization and drug development.<br>

scholarly journals Clinical trials and late-stage drug development for Alzheimer's disease: an appraisal from 1984 to 2014

2014 ◽  
Vol 275 (3) ◽  
pp. 251-283 ◽  
Author(s):  
L. S. Schneider ◽  
F. Mangialasche ◽  
N. Andreasen ◽  
H. Feldman ◽  
E. Giacobini ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Trials ◽  
Drug Development ◽  
Late Stage
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