Differential Regulation of TauT by Calcitriol and Retinoic Acid via VDR/RXR in LLC-PK1 and MCF-7 Cells

α1-Proteinase inhibitor is a serpin and can inhibit most serine proteinases. The cornea is one of several extrahepatic tissues that synthesizes this inhibitor. In the presence of retinol, corneal α1-proteinase inhibitor levels were increased 3.8-fold. The maximal response was achieved 2 h after the addition of retinol (1 μM final concentration) to the culture medium. A similar increase in α1-proteinase inhibitor was observed with retinaldehyde (1 nM final concentration). Concentrations of α1-proteinase inhibitor in other tested cells (Hep G2, CaCo 2, MCF-7, monocytes and macrophages) remained unchanged in the presence of retinol. Retinoic acid did not affect α1-proteinase inhibitor levels in the cornea or the other cells tested. The acute-phase cytokine, interleukin-6, increased α1-proteinase inhibitor levels in all tested tissues/cells except the cornea. These results demonstrate that α1-proteinase inhibitor levels are controlled differently in the cornea compared with other tissues/cells. α1-Proteinase inhibitor is the first protein identified whose levels are regulated by a mechanism supported by retinol and retinaldehyde but not retinoic acid.

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Transcriptional regulation of neutral sphingomyelinase 2 in all-trans retinoic acid-treated human breast cancer cell line, MCF-7

The Journal of Biochemistry ◽

10.1093/jb/mvs037 ◽

2012 ◽

Vol 151 (6) ◽

pp. 599-610 ◽

Cited By ~ 10

Author(s):

Hiromi Ito ◽

Kouji Tanaka ◽

Kazumi Hagiwara ◽

Misa Kobayashi ◽

Asuka Hoshikawa ◽

...

Keyword(s):

Breast Cancer ◽

Transcriptional Regulation ◽

Retinoic Acid ◽

Human Breast Cancer ◽

Cancer Cell Line ◽

Human Breast Cancer Cell ◽

Human Breast ◽

Trans Retinoic Acid ◽

All Trans Retinoic Acid ◽

Mcf 7

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Stemness marker ALDH1A1 promotes tumor angiogenesis via retinoic acid/HIF-1α/VEGF signalling in MCF-7 breast cancer cells

Journal of Experimental & Clinical Cancer Research ◽

10.1186/s13046-018-0975-0 ◽

2018 ◽

Vol 37 (1) ◽

Cited By ~ 20

Author(s):

Valerio Ciccone ◽

Erika Terzuoli ◽

Sandra Donnini ◽

Antonio Giachetti ◽

Lucia Morbidelli ◽

...

Keyword(s):

Breast Cancer ◽

Retinoic Acid ◽

Cancer Cells ◽

Tumor Angiogenesis ◽

Breast Cancer Cells ◽

Vegf Signalling ◽

Mcf 7

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VITAMIN D DERIVATIVES IN COMBINATION WITH 9-cis RETINOIC ACID PROMOTE ACTIVE CELL DEATH IN BREAST CANCER CELLS

Journal of Molecular Endocrinology ◽

10.1677/jme.0.0140391 ◽

1995 ◽

Vol 14 (3) ◽

pp. 391-394 ◽

Cited By ~ 53

Author(s):

S Y James ◽

A G Mackay ◽

K W Colston

Keyword(s):

Breast Cancer ◽

Vitamin D ◽

Retinoic Acid ◽

Cancer Cells ◽

Breast Cancer Cells ◽

P53 Protein ◽

Protein A ◽

Therapeutic Implications ◽

Protein Levels ◽

Mcf 7

ABSTRACT The effects of the novel vitamin D analogue, EB1089 alone, or in combination with the retinoid, 9-cis retinoic acid (9-cis RA) on indices of apoptosis in MCF-7 breast cancer cells have been examined. EB1089 was capable of reducing bcl-2 protein, a suppressor of apoptosis, and increasing p53 protein levels in MCF-7 cell cultures following 96h treatment. In the presence of 9-cis RA, EB1089 acted to further enhance the down-regulation and up-regulation of bcl-2 and p53 respectively. Furthermore, EB1089 induces DNA fragmentation in MCF-7 cells, a key feature of apoptosis, alone and in combination with 9-cis RA in situ. The observation that EB1089 and 9-cis RA act in a cooperative manner to enhance induction of apoptosis in these cells may have therapeutic implications.

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