Molecular Investigation of Escherichia Coli Virulence in Extraintestinal Infections

Author(s):  
Jörg Hacker ◽  
Joachim Morschhäuser ◽  
Manfred Ott ◽  
Reinhard Marre
2009 ◽  
Vol 138 (2) ◽  
pp. 253-263 ◽  
Author(s):  
J. C. SHU ◽  
J. H. CHIA ◽  
A. J. KUO ◽  
L. H. SU ◽  
T. L. WU

SUMMARYTo monitor the changing trend of extended-spectrum β-lactamase (ESBL)-producing bacteria, a 7-year continuous study was launched in 2001 at the largest tertiary hospital in Taiwan. A significant increase over the study period was evident for ESBL-producing isolates of Escherichia coli (4·8–10·0%) and Klebsiella pneumoniae (15·0–23·4%). Molecular investigation conducted in three separate periods revealed the prevalent ESBL types and their genetic relatedness. CTX-M-producing isolates (73·8%) were more prevalent than SHV-type ESBLs (37·0%), the most frequent being CTX-M-14 (34·3%), CTX-M-3 (25·9%), and SHV-12 (25·7%). However, a marked increase of CTX-M-15-producing isolates from 2·1% in 2002 to 29·6% in 2007 was also noted. The increase of ESBL-producing isolates in both species may be mainly due to the horizontal transmission of resistance plasmids, while clonal expansion of some epidemic strains further added to the dispersion of ESBL-producing K. pneumoniae.


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Mahnoosh Parsaeimehr ◽  
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Noriko ASANO ◽  
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Vol 27 (4) ◽  
pp. 589-593
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Alice Gonçalves Martins Gonzalez ◽  
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