Antioxidant Mechanisms of Enzymes and Proteins

1995 ◽  
pp. 238-272 ◽  
Author(s):  
Sami Ahmad
Keyword(s):  
Antioxidant Mechanisms

scholarly journals Propolis Extract and Its Bioactive Compounds—From Traditional to Modern Extraction Technologies

Molecules ◽  
2021 ◽  
Vol 26 (10) ◽  
pp. 2930
Author(s):  
Jelena Šuran ◽  
Ivica Cepanec ◽  
Tomislav Mašek ◽  
Božo Radić ◽  
Saša Radić ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Geographical Origin ◽  
Research Area ◽  
Mechanisms Of Action ◽  
Bioactive Molecules ◽  
Erk Pathway ◽  
Pharmacological Effects ◽  
Propolis Extract ◽  
Open Research ◽  
Antioxidant Mechanisms

Propolis is a honeybee product known for its antioxidant, anti-inflammatory, anticancer, and antimicrobial effects. It is rich in bioactive molecules whose content varies depending on the botanical and geographical origin of propolis. These bioactive molecules have been studied individually and as a part of propolis extracts, as they can be used as representative markers for propolis standardization. Here, we compare the pharmacological effects of representative polyphenols and whole propolis extracts. Based on the literature data, polyphenols and extracts act by suppressing similar targets, from pro-inflammatory TNF/NF-κB to the pro-proliferative MAPK/ERK pathway. In addition, they activate similar antioxidant mechanisms of action, like Nrf2-ARE intracellular antioxidant pathway, and they all have antimicrobial activity. These similarities do not imply that we should attribute the action of propolis solely to the most representative compounds. Moreover, its pharmacological effects will depend on the efficacy of these compounds’ extraction. Thus, we also give an overview of different propolis extraction technologies, from traditional to modern ones, which are environmentally friendlier. These technologies belong to an open research area that needs further effective solutions in terms of well-standardized liquid and solid extracts, which would be reliable in their pharmacological effects, environmentally friendly, and sustainable for production.

Neuroprotective and Antioxidant Effects of Riparin I in a Model of Depression Induced by Corticosterone in Female Mice

2021 ◽  
pp. 1-11
Author(s):  
Iris Cristina Maia Oliveira ◽  
Auriana Serra Vasconcelos Mallmann ◽  
Francisco Adelvane de Paula Rodrigues ◽  
Laura Maria Teodorio Vidal ◽  
Iardja Stéfane Lopes Sales ◽  
...  
Keyword(s):  
New Drugs ◽  
Antidepressant Effect ◽  
Therapeutic Drug ◽  
Female Mice ◽  
Potential Source ◽  
Treatment Of Depression ◽  
Animal Model Of Depression ◽  
Strong Candidate ◽  
Antioxidant Mechanisms ◽  
Antioxidant Effects

<b><i>Background:</i></b> Depression is a common, chronic, and often recurrent serious mood disorder. Conventional antidepressants present limitations that stimulate the search for new drugs. Antioxidant and neuroprotective substances are potential antidepressant agents. In this context, riparin I (RIP I) has presented promising results, emerging as a potential source of a new therapeutic drug. In this study, the antidepressant effect of RIP I was evaluated in an animal model of depression induced by corticosterone (CORT). The involvement of neuroprotective and antioxidant mechanisms in the generation of this effect was also assessed. <b><i>Methods:</i></b> Female mice were submitted to CORT for 21 days and treated with RIP I in the last 7 days. Behavioral and neurochemical analyses were performed. <b><i>Results:</i></b> The administration of RIP I reversed the depressive and psychotic-like behavior, as well as the cognitive impairment caused by CORT, in addition to regulating oxidative stress parameters and BDNF levels in depression-related brain areas. <b><i>Conclusion:</i></b> These findings suggest that RIP I can be a strong candidate for drugs in the treatment of depression.

scholarly journals Pomegranate-mediated chemoprevention of experimental hepatocarcinogenesis involves Nrf2-regulated antioxidant mechanisms

2011 ◽  
Vol 32 (6) ◽  
pp. 888-896 ◽  
Author(s):  
Anupam Bishayee ◽  
Deepak Bhatia ◽  
Roslin J. Thoppil ◽  
Altaf S. Darvesh ◽  
Eviatar Nevo ◽  
...  
Keyword(s):  
Antioxidant Mechanisms

scholarly journals Peroxisomal APX knockdown triggers antioxidant mechanisms favourable for coping with high photorespiratory H2O2induced by CAT deficiency in rice

2014 ◽  
Vol 38 (3) ◽  
pp. 499-513 ◽  
Author(s):  
RACHEL H. V. SOUSA ◽  
FABRICIO E. L. CARVALHO ◽  
CAROL W. RIBEIRO ◽  
GISELE PASSAIA ◽  
JULIANA R. CUNHA ◽  
...  
Keyword(s):  
Antioxidant Mechanisms

scholarly journals Mitogenic and Antioxidant Mechanisms of Estradiol Action in Preovulatory Ovine Follicles: Relevance to Luteal Function1

1999 ◽  
Vol 61 (2) ◽  
pp. 388-392 ◽  
Author(s):  
Staci A. Lund ◽  
Jenifer Murdoch ◽  
Edward A. Van Kirk ◽  
William J. Murdoch
Keyword(s):  
Antioxidant Mechanisms

Early Activation of Antioxidant Mechanisms in Muscle of Mutant Cu/Zn-Superoxide Dismutase-Linked Amyotrophic Lateral Sclerosis Mice

2003 ◽  
Vol 1010 (1) ◽  
pp. 552-556 ◽  
Author(s):  
NATASA JOKIC ◽  
FRANCK DI SCALA ◽  
LUC DUPUIS ◽  
FREDERIQUE RENE ◽  
ANDRE MULLER ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Superoxide Dismutase ◽  
Early Activation ◽  
Antioxidant Mechanisms ◽  
Lateral Sclerosis

Failure of Implantation in IVF due to oxidative stress

2021 ◽  
Vol 20 (2) ◽  
pp. 45-52
Author(s):  
Sofoklis Stavros ◽  
Antonios Koutras ◽  
Thomas Ntounis ◽  
Konstantinos Koukoubanis ◽  
Theodoros Papalios ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Reproductive Tract ◽  
Sperm Quality ◽  
Reactive Oxygen ◽  
Female Reproductive Tract ◽  
Oxygen Species ◽  
Stress Markers ◽  
Multiple Levels ◽  
Antioxidant Mechanisms

Oxidative stress may play a role in implantation failure on multiple levels. Oxidative stress is found widely in several biological systems, as well as it acts on various molecular levels with different mechanisms. It has been shown that it is rather the disequilibrium between reactive oxygen species causing oxidative stress and antioxidant mechanisms counteracting their effects, than reactive oxygen species levels themselves. Reactive oxygen species play a role in implantation and fertilisation by acting on different levels of embryo-formation and endometrial changes. Additionally, it is widely abundant in the female reproductive tract including ovaries, oocytes, tubal as well as follicular fluid. Moreover, it has been shown that male fertility is affected by reactive oxygen species by determining sperm quality. Last but not least, oxidative stress may affect IVF indirectly through its actions on peritoneal fluid. As long as research studies on elucidating the development of oxidative stress markers on patients undergoing IVF continue, ever more new possibilities emerge on predicting the pregnancy outcome.

Sign in / Sign up

Export Citation Format

Share Document