Determination of the Superconducting Transition Onset Temperature in Small-Volume Specimens

1989 ◽  
pp. 415-422
Author(s):  
T. F. Ciszek ◽  
E. Tarsa
Keyword(s):  
Small Volume ◽  
Onset Temperature ◽  
Superconducting Transition

Bioassay Method for the Determination of Toxaphene in Lake Water

1966 ◽  
Vol 23 (5) ◽  
pp. 723-727
Author(s):  
L. M. Royer
Keyword(s):  
Lake Water ◽  
Small Volume ◽  
Bioassay Method ◽  
Lebistes Reticulatus

A method based on static bioassays was developed to measure the concentration of toxaphene before restocking of lakes treated with this toxicant. A double distillation technique was used to extract the toxaphene and concentrate it in a small volume of distillate. Bioassays were then carried out in 200-ml samples of distillate reconstituted with electrolytes to match a standard water. Guppies, Lebistes reticulatus (Peters), less than 7 days old were used as test organisms.The method developed was used to follow the detoxification of Midway Lake which was rehabilitated with toxaphene. Data on the rate of detoxification are presented.

A Literature Study of IPQC (In Process Quality Control) tests and FDF (Finished Dosage Form) tests for Parenteral Dosage forms taking Adicovil IV Ampoule as an Example.

2017 ◽  
Vol II (I) ◽  
pp. 44-55
Author(s):  
Ayesha Sabir ◽  
Syeda Komal Fatima ◽  
Asma Kaleem ◽  
Sidra Altaf ◽  
Imran Khan
Keyword(s):  
Quality Control ◽  
Dosage Form ◽  
Small Volume ◽  
Volatile Matter ◽  
Process Quality ◽  
Type I ◽  
Literature Study ◽  
Physical Tests ◽  
Parenteral Product

This study was conducted to evaluate both the in-process quality control tests as well as the finished dosage form tests for a parenteral product. Furthermore, all the processes from the purchase of API to marketing of product were studied. A batch of Adicovil was taken Adicovil was taken as an example, it is small volume parenteral of 2ml ampoule that is studied to evaluate its efficacy and stability by performing chemical and physical tests. IPQC tests for type I glass includes powder glass test, while for water for injection they are pH, acidity & alkalinity, non-volatile matter, ammonium ions, non-oxidizable matter, sterility and pyrogen test. Test for finished dosage form of Adicovil are identification, leaker test, clarity test, sterility, pyrogen test, BET, deliverable volume and determination of volume of injection for container. The selected batch of Adicovil passed all the IPQC and FDF tests in the procedure.

Disposable Cartridge Extraction of Retinol and α-Tocopherol from Feedstuffs

1985 ◽  
Vol 68 (6) ◽  
pp. 1121-1125
Author(s):  
Claude F Bourgeois ◽  
Sylvie H Hel ◽  
Jean-Pierre Belliot ◽  
Philippe R George ◽  
Catherine A Slomianny
Keyword(s):  
Small Volume ◽  
Potassium Hydroxide Solution ◽  
Normal Pressure ◽  
Aqueous Alcohol ◽  
Appreciable Increase ◽  
Extraction Step ◽  
Fat Soluble Vitamins ◽  
Feed Samples ◽  
Automated Determination

Abstract Automated determination of fat-soluble vitamins by modern methods such as liquid chromatography is hampered by the initial extraction step. A simple technique is proposed that allows an appreciable increase in the actual rates of determination. Feedstuff samples are first hydrolyzed in an aqueous alcohol (mainly methanol)-potassium hydroxide solution. Instead of extracting retinol and a-tocopherol from the hydrolysis solution by an organic solvent, an aliquot of the solution is mixed with a small volume of a strong antioxidant solution (ascorbic acid) and pipetted onto a kieselguhr disposable cartridge where it is adsorbed. Retinol and a-tocopherol are eluted with isooctane at normal pressure. The proposed method has been compared with conventional techniques on many feed samples.

Determination of Glycerol in Cosmetics by GLC. I. Development of the Method

1967 ◽  
Vol 50 (6) ◽  
pp. 1287-1291
Author(s):  
Frederick C Gross ◽  
John H Jones
Keyword(s):  
Small Volume ◽  
Cosmetic Products

Abstract Glycerol, in the absence of water, may be determined easily and accurately by GLC on a column containing SAIB on silanized Chromosorb G. Aqueous glycerol solutions are dehydrated without loss of glycerin by adding 2-methoxyethanol and evaporating to a small volume. Procedures for determining glycerol in various cosmetic products are described; recoveries of glycerol by the proposed procedure ranged from 95 to 105%.

scholarly journals Multiresidue Determination of Fluoroquinolones in Eggs

2000 ◽  
Vol 83 (6) ◽  
pp. 1306-1312 ◽  
Author(s):  
Marilyn J Schneider ◽  
Dan J Donoghue
Keyword(s):  
Liquid Chromatography ◽  
Fluorescence Detection ◽  
Small Volume ◽  
Reversed Phase ◽  
Reversed Phase Liquid Chromatography ◽  
Trace Enrichment ◽  
On Line ◽  
Phase Liquid ◽  
Multiresidue Determination

Abstract A multiresidue method was developed for the determination of fluoroquinolones in eggs. Extraction of eggs with ammoniacal acetonitrile was followed by liquid–liquid defatting, solvent evaporation, and redissolution in a small volume of buffer. The fluoroquinolones were further purified by on-line microdialysis, concentrated on a trace enrichment column, and separated by reversed-phase liquid chromatography with fluorescence detection. Norfloxacin (NOR), ciprofloxacin (CIP), and sarafloxacin (SAR) were extracted from fortified eggs over a range of 2–200 μg/kg, with recoveries of 65.7–78.9%, 65.6–77.1%, and 67.6–110%, respectively. Enrofloxacin (ENRO) was extracted over a range of 1–100 μg/kg, with recoveries of 71.5–86.7%, whereas desethylene ciprofloxacin (DCIP) and danofloxacin (DANO) were extracted over a range of 0.2–20 μg/kg, with recoveries of 68.7–90.7% and 76.0–93.8%, respectively. The limits of quantitation for the 6 fluoroquinolones were as follows: DCIP and DANO, 0.3 μg/kg; ENRO, 1 μg/kg; NOR and CIP, 2 μg/kg; and SAR, 3 μg/kg. Both SAR and ENRO incurred eggs were also successfully analyzed using this method.

A sensitive HPLC-FL method to simultaneously determine febuxostat and diclofenac in rat plasma: assessment of metabolic drug interactions in vitro and in vivo

2020 ◽  
Vol 12 (16) ◽  
pp. 2166-2175 ◽  
Author(s):  
Dong-Gyun Han ◽  
Kyu-Sang Kim ◽  
Seong-Wook Seo ◽  
Young Mee Baek ◽  
Yunjin Jung ◽  
...  
Keyword(s):  
Sample Preparation ◽  
Drug Interactions ◽  
Simultaneous Determination ◽  
Small Volume ◽  
Rat Plasma ◽  
Metabolic Drug ◽  
Simple Sample Preparation

We developed a sensitive, simple and validated HPLC-FL method for simultaneous determination of FEB and DIC in rat plasma. The method requires a relatively small volume of sample, has simple sample preparation and excellent sensitivity.

Determination of Reserpine in Tablets by Liquid Chromatography with Fluorescence Detection: Revised Procedure

1994 ◽  
Vol 77 (3) ◽  
pp. 758-760
Author(s):  
Ugo R Cieri
Keyword(s):  
Aqueous Solution ◽  
Liquid Chromatography ◽  
Fluorescence Detection ◽  
Sodium Salt ◽  
Filter Paper ◽  
Mobile Phase ◽  
Small Volume ◽  
Slight Modification ◽  
Reference Solution

Abstract A procedure is presented for the determination of reserpine in tablets by liquid chromatography (LC) that is a slight modification of a method presented in a previous publication. The sample is extracted with methanol, and solutions are filtered through filter paper. For LC, a 7.5 cm column is used; the mobile phase is methanol containing a small volume of an aqueous solution of the sodium salt of 1-pentanesulfonic acid. Detection is by fluorescence with 280 nm excitation and 360 nm emission. Two commercial samples containing 0.1 and 0.25 mg reserpine were analyzed. For each sample, 2 determinations were made on a ground composite. Ten tablets were also analyzed individually. A linearity study was conducted, with solutions ranging in concentration from 80 to 120% of the amount present in the reference solution.

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