Free Radicals, Muscle Damage and Muscular Dystrophy

1988 ◽  
pp. 197-210 ◽  
Author(s):  
M. J. Jackson ◽  
R. H. T. Edwards
Keyword(s):  
Free Radicals ◽  
Muscular Dystrophy ◽  
Muscle Damage

Differential diagnosis of Duchenne muscular dystrophy

2021 ◽  
Vol 2 (3) ◽  
pp. 159-166
Author(s):  
Alexey L. Kurenkov ◽  
Lyudmila M. Kuzenkova ◽  
Lale A. Pak ◽  
Bella I. Bursagova ◽  
Tatyana V. Podkletnova ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Muscle Damage ◽  
Genetic Diagnosis ◽  
Clinical Manifestations ◽  
Neuromuscular Diseases ◽  
Muscular Dystrophies ◽  
Juvenile Form ◽  
Pathogenic Variants

Duchenne muscular dystrophy (DMD) is a disease with an X-linked recessive type of inheritance, belonging to a group of disorders with primary muscle damage, caused by pathogenic variants in the DMD gene and associated with dysfunction of the dystrophin protein. Since DMD is manifested by the gradual development of progressive, mainly proximal muscle weakness, the differential diagnosis is primarily carried out in the group of diseases with muscle damage - myopathies. Among these diseases, the leading candidates for differential diagnosis are hereditary myopathies (limb-girdle muscular dystrophies, facioscapulohumeral dystrophy, congenital muscular dystrophies, glycogenoses - the most common juvenile form of glycogenosis type II (Pompe disease)) and, much less often, congenital myopathies and other conditions of neuromuscular diseases). When conducting a differential diagnosis in a child with suspected DMD, the age of the onset of the disease, early initial clinical manifestations and the development of symptoms as they grow, genealogical analysis, laboratory tests (the level of creatine kinase, aspartate aminotransferase, alanine aminotransferase in blood serum), instrumental (electromyography, magnetic resonance imaging of the brain and muscles) and molecular genetics (polymerase chain reaction, multiplex ligation-dependent probe amplification, next-generation sequencing, Sanger sequencing, etc.) of studies, and in some cases, muscle biopsy data. Knowledge of the nuances of the differential diagnosis allows establishing a genetic diagnosis of DMD as early as possible, which is extremely important for the formation of the prognosis of the disease and the implementation of all available treatment methods, including pathogenetic therapy, and is also necessary for medical and genetic counselling of families with DMD patients.

Free radicals and muscle damage

1993 ◽  
Vol 49 (3) ◽  
pp. 630-641 ◽  
Author(s):  
M J Jackson ◽  
S O' Farrell
Keyword(s):  
Free Radicals ◽  
Muscle Damage

RNA profiling discloses a link between circadian genes and muscle damage in Duchenne muscular dystrophy

2016 ◽  
Vol 26 ◽  
pp. S157-S158
Author(s):  
A. Armaroli ◽  
C. Scotton ◽  
H. Osman ◽  
M. Falzarano ◽  
R. Capogrosso ◽  
...  
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Muscle Damage ◽  
Circadian Genes ◽  
Rna Profiling

EPA protects against muscle damage in the mdx mouse model of Duchenne muscular dystrophy by promoting a shift from the M1 to M2 macrophage phenotype

2013 ◽  
Vol 264 (1-2) ◽  
pp. 41-47 ◽  
Author(s):  
Samara Camaçari de Carvalho ◽  
Leticia Montanholi Apolinário ◽  
Selma Maria Michelin Matheus ◽  
Humberto Santo Neto ◽  
Maria Julia Marques
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Mouse Model ◽  
Muscle Damage ◽  
Mdx Mouse ◽  
M2 Macrophage ◽  
Macrophage Phenotype

A Plasma Creatine Kinase MM Isoforms in the Study of Muscle Damage in Muscular Dystrophy

1987 ◽  
Vol 73 (s17) ◽  
pp. 50P-50P
Author(s):  
S Page ◽  
MJ Jackson ◽  
J Coakley ◽  
RHT Edwards
Keyword(s):  
Creatine Kinase ◽  
Muscular Dystrophy ◽  
Muscle Damage ◽  
Plasma Creatine Kinase
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