A Plasma Creatine Kinase MM Isoforms in the Study of Muscle Damage in Muscular Dystrophy

1987 ◽  
Vol 73 (s17) ◽  
pp. 50P-50P
Author(s):  
S Page ◽  
MJ Jackson ◽  
J Coakley ◽  
RHT Edwards
Keyword(s):  
Creatine Kinase ◽  
Muscular Dystrophy ◽  
Muscle Damage ◽  
Plasma Creatine Kinase

Factors Influencing Plasma Creatine Kinase Activities of Patients with Muscular Dystrophy

1985 ◽  
Vol 69 (s12) ◽  
pp. 82P-82P
Author(s):  
R.H.T Edwards ◽  
J.M. Round ◽  
D. Newham ◽  
M.J. Jackson
Keyword(s):  
Creatine Kinase ◽  
Muscular Dystrophy ◽  
Factors Influencing ◽  
Plasma Creatine Kinase

Plasma creatine kinase activity and exercise-induced muscle damage in older men

1991 ◽  
Vol 23 (9) ◽  
pp. 1028???1034 ◽  
Author(s):  
THOMAS G. MANFREDI ◽  
ROGER A. FIELDING ◽  
KEVIN P. O??REILLY ◽  
CAROL N. MEREDITH ◽  
HO YONG LEE ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Muscle Damage ◽  
Kinase Activity ◽  
Older Men ◽  
Creatine Kinase Activity ◽  
Exercise Induced ◽  
Plasma Creatine Kinase ◽  
Plasma Creatine Kinase Activity

Diminished cap formation in lymphocytes from patients and carriers of Duchenne muscular dystrophy.

1977 ◽  
Vol 23 (12) ◽  
pp. 2341-2343 ◽  
Author(s):  
H L Verrill ◽  
N A Pickard ◽  
H D Gruemer
Keyword(s):  
Creatine Kinase ◽  
Genetic Counseling ◽  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Clinical Laboratory ◽  
Carrier State ◽  
Childbearing Age ◽  
Plasma Creatine Kinase

Abstract Currently, the most useful clinical laboratory aid in establishing the carrier state of Duchenne muscular dystrophy is to determine creatine kinase (EC 2.7.3.2) activity in the plasma. The considerable overlap between plasma creatine kinase activities of controls and of carriers at the childbearing age contributes appreciable difficulty to genetic counseling of potential carriers. The consistent failure of lymphocyte cap formation in Duchenne muscular dystrophy patients and carriers in this study suggests a valuable tool for the confirmation of the carrier state.

Use of plasma creatine kinase pharmacokinetics to estimate the amount of exercise-induced muscle damage in Beagles

2001 ◽  
Vol 62 (9) ◽  
pp. 1375-1380 ◽  
Author(s):  
Guillaume P. Chanoit ◽  
Herve P. Lefebvre ◽  
Karine Orcel ◽  
Valerie Laroute ◽  
Pierre-Louis Toutain ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Muscle Damage ◽  
Exercise Induced ◽  
Plasma Creatine Kinase

scholarly journals The Relationship Between muscle Damage and Activity Profiles During Team Handball Matches

2020 ◽  
Vol 13 (1) ◽  
pp. 1-11
Author(s):  
Koji Akashi ◽  
Mamoru Tanaka
Keyword(s):  
Creatine Kinase ◽  
Muscle Damage ◽  
Kinase Activity ◽  
Creatine Kinase Activity ◽  
The Body ◽  
Team Handball ◽  
Team Game ◽  
The Relationship ◽  
Plasma Creatine Kinase ◽  
Plasma Creatine Kinase Activity

Background: Anaerobic activities often require explosive muscle power; it is therefore possible that players’ skeletal muscles sustain damage during the game, which leads to a performance decrease as the game progresses. Objective: This study investigated the relationship between muscle damage and activity profiles during team handball matches. Methods: This study conducted two handball games to examine the relationship between muscle damage and impacts against the body during the games. We studied one handball match between members of the same university team (Game I: 12 male court players) and a practice match between a Japanese handball league team and the university student team (Game II: nine male court players and six controls). Results: Plasma myoglobin concentration and plasma creatine kinase activity, both of which are biomarkers for muscle damage, increased to above their normal ranges after both games. The magnitudes of the changes in both plasma myoglobin (p<.05) and plasma creatine kinase activity (p<0.05) from before to after the game were significantly different between the players and controls in Game II. There were significant correlations between the number of shots taken in Game II and biomarkers for muscle damage; the changes in plasma myoglobin concentrations (p<0.01) and plasma creatine kinase (p< 0.01) activity levels. Conclusion: These results suggest that team handball matches involve high-intensity exercise that is sufficient to cause muscle damage. Additionally, our findings suggest that the severity of muscle damage is related to the specific actions associated with taking shots, such as jumping and colliding with a defender.

The Effects of Leucine-Enriched Branched-Chain Amino Acid Supplementation on Recovery After High-Intensity Resistance Exercise

2019 ◽  
Vol 14 (8) ◽  
pp. 1081-1088 ◽  
Author(s):  
Adam D. Osmond ◽  
Dean J. Directo ◽  
Marcus L. Elam ◽  
Gabriela Juache ◽  
Vince C. Kreipke ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Resistance Exercise ◽  
Muscle Damage ◽  
Peak Power ◽  
Average Power ◽  
Amino Acid Supplementation ◽  
Performance Recovery ◽  
Branched Chain ◽  
Exercise Induced ◽  
Plasma Creatine Kinase

Context: Of the 3 branched-chain amino acids (BCAA), leucine has arguably received the most attribution for the role of BCAA supplementation in alleviating symptoms of exercise-induced muscle damage and facilitation of acute performance recovery. Purpose: To examine whether enrichment of a standard BCAA supplement with additional leucine or a standalone leucine (LEU) supplement differentially affects exercise-induced muscle damage and performance recovery compared with a standard BCAA supplement. Methods: A total of 22 recreationally active male and female subjects were recruited and assigned to consume a BCAA, leucine-enriched BCAA (LBCAA), or LEU supplement for 11 d. On the eighth day, subjects performed eccentric-based resistance exercise (ECRE). Lower-body mean average and peak power, plasma creatine kinase, soreness, and pain threshold were measured before and 24, 48, and 72 h after ECRE. Results: LEU showed decreased mean average power (P = .02) and mean peak power (P = .01) from baseline to 48 h post-ECRE, whereas LBCAA and BCAA only trended toward a reduction at 24 hours post-ECRE. At 48 h post-ECRE, BCAA showed greater recovery of mean peak power than LEU (P = .04). At 24 h post-ECRE, LEU demonstrated a greater increase in plasma creatine kinase from baseline than BCAA (P = .04). Area under the curve for creatine kinase was greater in LEU than BCAA (P = .02), whereas BCAA and LBCAA did not differ. Only LEU demonstrated increased soreness during rest and under muscular tension at 24 and 48 h post-ECRE (P < .05). Conclusions: LBCAA failed to afford any advantages over a standard BCAA supplement for postexercise muscle recovery, whereas a LEU supplement was comparatively ineffective.

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