The Autoxidation of Polyunsaturated Lipids

1988 ◽  
pp. 55-79 ◽  
Author(s):  
Ned A. Porter ◽  
Dennis G. Wujek
Keyword(s):  
Polyunsaturated Lipids

Visible-Light Activated [2+2] Photocycloaddition Reaction Enabled Identification of Carbon-Carbon Double Bonds Position Isomerism in Structural Lipidomics

2020 ◽  
Author(s):  
Guifang Feng ◽  
Yanhong Hao ◽  
Liang Wu ◽  
Suming Chen
Keyword(s):  
Visible Light ◽  
Uv Light ◽  
Practical Importance ◽  
Side Reactions ◽  
Potential Health ◽  
Fundamental Interest ◽  
Unsaturated Lipids ◽  
Health Damage ◽  
Global Identification ◽  
Polyunsaturated Lipids

The photocycloaddition of olefins with carbonyls is of fundamental interest and practical importance in C=C bond location in unsaturated lipids. However, the traditional UV light activated [2+2] photocycloaddition reaction suffers side reactions and potential health damage. Here, we reported the first example of visible-light activated [2+2] photocycloaddition of anthraquinone with unsaturated lipids. This reaction showed great capability for locating the C=C bonds in various kinds of monounsaturated and polyunsaturated lipids by combining with tandem mass spectrometry (MS), such as fatty acids, phospholipids and glycerides. Based on this developed reaction, a workflow with liquid chromatography tandem MS method was developed for the global identification of unsaturated lipids in human serum, and 86 of monounsaturated and complicated polyunsaturated lipids were identified with definitive positions of C=C bonds. This approach provides new insights both on the photocycloaddition reactions and the structural lipidomics.

Structural and Bioactive Studies of Halogenated Constituents from Sponges

2020 ◽  
Vol 27 (14) ◽  
pp. 2335-2360 ◽  
Author(s):  
Chao Li ◽  
Dayong Shi
Keyword(s):  
Microbial Communities ◽  
Organic Compounds ◽  
Biological Activities ◽  
Marine Sponges ◽  
Nitrogen Compounds ◽  
Halogenated Organic Compounds ◽  
Bioactive Natural Products ◽  
The Past ◽  
Tyrosine Derivatives ◽  
Polyunsaturated Lipids

: Marine organisms are abundant sources of bioactive natural products. Among metabolites produced by sponges and their associated microbial communities, halogenated natural compounds accounted for an important part due to their potent biological activities. The present review updates and compiles a total of 258 halogenated organic compounds isolated in the past three decades, especially brominated derivatives derived from 31 genera of marine sponges. These compounds can be classified as the following classes: brominated polyunsaturated lipids, nitrogen compounds, brominated tyrosine derivatives and other halogenated compounds. These substances were listed together with their source organisms, structures and bioactivities. For this purpose, 84 references were consulted.

scholarly journals Polyunsaturated Lipids Regulate Membrane Domain Stability by Tuning Membrane Order

2016 ◽  
Vol 110 (8) ◽  
pp. 1800-1810 ◽  
Author(s):  
Kandice R. Levental ◽  
Joseph H. Lorent ◽  
Xubo Lin ◽  
Allison D. Skinkle ◽  
Michal A. Surma ◽  
...  
Keyword(s):  
Membrane Domain ◽  
Membrane Order ◽  
Polyunsaturated Lipids ◽  
Domain Stability

Polyunsaturated Lipids and Tocopherol Requirements

1961 ◽  
Vol 38 (3) ◽  
pp. 231-235
Author(s):  
M.K. Horwitt ◽  
C.C. Harvey ◽  
B. Century ◽  
L.A. Witting
Keyword(s):  
Polyunsaturated Lipids

Inhibition of calcineurin by polyunsaturated lipids

2006 ◽  
Vol 34 (2) ◽  
pp. 66-76 ◽  
Author(s):  
Abigail M. Tokheim ◽  
Bruce L. Martin
Keyword(s):  
Polyunsaturated Lipids

Encapsulation, protection, and release of polyunsaturated lipids using biopolymer-based hydrogel particles

2014 ◽  
Vol 64 ◽  
pp. 520-526 ◽  
Author(s):  
Zipei Zhang ◽  
Eric Andrew Decker ◽  
David Julian McClements
Keyword(s):  
Hydrogel Particles ◽  
Polyunsaturated Lipids

Order from disorder, corralling cholesterol with chaotic lipidsThe role of polyunsaturated lipids in membrane raft formation

2004 ◽  
Vol 132 (1) ◽  
pp. 79-88 ◽  
Author(s):  
S WASSALL ◽  
M BRZUSTOWICZ ◽  
S SHAIKH ◽  
V CHEREZOV ◽  
M CAFFREY ◽  
...  
Keyword(s):  
Membrane Raft ◽  
Polyunsaturated Lipids

scholarly journals Therapeutic Effects of Specialized Pro-Resolving Lipids Mediators on Cardiac Fibrosis via NRF2 Activation

Antioxidants ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 1259
Author(s):  
Gyeoung Jin Kang ◽  
Eun Ji Kim ◽  
Chang Hoon Lee
Keyword(s):  
Oxidative Stress ◽  
Cardiac Fibrosis ◽  
Lipid Mediators ◽  
Therapeutic Effects ◽  
Related Factor ◽  
Nuclear Factor ◽  
Docosahexanoic Acid ◽  
Nrf2 Activation ◽  
The World ◽  
Polyunsaturated Lipids

Heart disease is the number one mortality disease in the world. In particular, cardiac fibrosis is considered as a major factor causing myocardial infarction and heart failure. In particular, oxidative stress is a major cause of heart fibrosis. In order to control such oxidative stress, the importance of nuclear factor erythropoietin 2 related factor 2 (NRF2) has recently been highlighted. In this review, we will discuss the activation of NRF2 by docosahexanoic acid (DHA), eicosapentaenoic acid (EPA), and the specialized pro-resolving lipid mediators (SPMs) derived from polyunsaturated lipids, including DHA and EPA. Additionally, we will discuss their effects on cardiac fibrosis via NRF2 activation.

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