Placental Distribution and the Effect of Antihypertensive Drugs on Monoamine Oxidase and Cathechol-o-Methyl Transferase Activity at Term

1987 ◽  
pp. 305-314
Author(s):  
Eytan R. Barnea ◽  
A. H. De Cherney ◽  
Frederick Naftolin
Keyword(s):  
Monoamine Oxidase ◽  
Antihypertensive Drugs ◽  
Transferase Activity ◽  
Methyl Transferase

Noradrenaline and normetadrenaline metabolism in portal cirrhosis

1964 ◽  
Vol 207 (5) ◽  
pp. 1087-1094 ◽  
Author(s):  
McC. Goodall ◽  
Harold Alton ◽  
Martha Henry
Keyword(s):  
Monoamine Oxidase ◽  
Alcoholic Cirrhosis ◽  
Transferase Activity ◽  
Monoamine Oxidase Activity ◽  
Noradrenaline Metabolism ◽  
Portal Cirrhosis ◽  
Indwelling Catheter ◽  
Methyl Transferase ◽  
Metabolic Products ◽  
Sulfate Conjugate

Four patients with moderate to severe portal (alcoholic) cirrhosis were injected intravenously with dl-noradrenaline-2-C14. Urine was collected via an indwelling catheter at 10-min intervals for 1 hr and thereafter for 6 and 24 hr. The metabolic products of noradrenaline were separated, identified, and their radioactivity measured. The same subjects were also injected with dl-normetadrenaline-1-C14, the O-methylated metabolic product of noradrenaline, and the urine samples similarly processed. The results seem to indicate that in portal cirrhosis noradrenaline metabolism is altered. In the period immediately following the injection of noradrenaline there is a slight decrease in the catechol-O-methyl transferase activity but thereafter it is either unchanged or slightly increased. Further, the cirrhotic shows a distinct predilection for conjugating both noradrenaline and normetadrenaline. This is reflected by a significant increase in the sulfate conjugate of both of these compounds. The monoamine oxidase activity is decreased slightly throughout the collection periods. This is reflected by a decrease in the formation of 3-methoxy-4-hydroxymandelic acid following an injection of both noradrenaline and normetadrenaline.

Monoamine Oxidase and Catechol-O-Methyl Transferase Activity inTetrahymena*

1977 ◽  
Vol 24 (3) ◽  
pp. 459-462 ◽  
Author(s):  
JEROME M. FELDMAN ◽  
JOAN M. ROCHE ◽  
J. J. BLUM
Keyword(s):  
Monoamine Oxidase ◽  
Transferase Activity ◽  
Methyl Transferase

THE METABOLISM OF CATECHOLAMINES IN HYPERTHYROID AND VITAMIN B12 DEFICIENT RATS

1966 ◽  
Vol 44 (12) ◽  
pp. 1577-1585 ◽  
Author(s):  
L. Proulx ◽  
A. D'Iorio ◽  
M. Beznak
Keyword(s):  
Body Weight ◽  
Monoamine Oxidase ◽  
Vitamin B12 ◽  
Oxidase Activity ◽  
Vitamin B ◽  
Transferase Activity ◽  
Monoamine Oxidase Activity ◽  
Methyl Transferase ◽  
Noradrenaline And Adrenaline

The effect of hyperthyroidism and vitamin B12 deficiency was studied on liver monoamine oxidase, liver catechol-O-methyl transferase, and the noradrenaline and adrenaline content of liver, heart, and brain. In the hyperthyroid rats, there was a 25% decrease in liver monoamine oxidase and this decrease does not appear to be related to a decrease in body weight. Liver catechol-O-methyl transferase activity was normal in hyperthyroid animals. The noradrenaline and adrenaline content of liver, heart, and brain were also not modified. Vitamin B12 deficiency did not affect catechol-O-methyl transferase activity but hepatic monoamine oxidase was lower by 20–30% in rats supplemented with the vitamin. In vitro, vitamin B12 and methyl cobalamin did not modify the activity of catechol-O-methyl transferase in concentrations ranging from 1 × 10−3 M to 1 × 10−6 M. Vitamin B12 also did not affect monoamine oxidase activity at concentrations of 1 × 10−4 M to 1 × 10−5 M.

scholarly journals Methionine sulfoxide reductase regulates brain catechol-O-methyl transferase activity

2014 ◽  
Vol 17 (10) ◽  
pp. 1707-1713 ◽  
Author(s):  
Jackob Moskovitz ◽  
Consuelo Walss-Bass ◽  
Dianne A. Cruz ◽  
Peter M. Thompson ◽  
Marco Bortolato
Keyword(s):  
Methionine Sulfoxide ◽  
Methionine Sulfoxide Reductase ◽  
Transferase Activity ◽  
Methyl Transferase

scholarly journals Dopamine in the Pathophysiology of Preeclampsia and Gestational Hypertension: Monoamine Oxidase (MAO) and Catechol-O-methyl Transferase (COMT) as Possible Mechanisms

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Wendy N. Phoswa
Keyword(s):  
Monoamine Oxidase ◽  
Gestational Hypertension ◽  
Morbidity And Mortality ◽  
Therapeutic Interventions ◽  
Hypertensive Disorders Of Pregnancy ◽  
Methyl Transferase ◽  
Hypertension In Pregnancy ◽  
Health Burden ◽  
Hypertensive Disorders ◽  
In Pregnancy

Purpose of the Review. Hypertension in pregnancy is the global health burden. Amongst the hypertensive disorders of pregnancy, preeclampsia and gestational hypertension are the world’s leading disorders that lead to both maternal and fetal morbidity and mortality. Recent Findings. Dopamine inactive metabolites, namely, monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT), have been reported to be associated with hypertensive disorders of pregnancy such preeclampsia and gestational hypertension. Summary. This review discusses the involvement of MAO and COMT in the pathophysiology of both conditions in order to have a better understanding on the pathogenesis of both conditions, suggesting promising therapeutic interventions and subsequently reducing maternal and fetal morbidity and mortality.

Methionine-activating Enzyme and Catechol-O-methyl Transferase Activity in Normal and Leukaemic White Blood Cells

Nature ◽  
1966 ◽  
Vol 209 (5018) ◽  
pp. 78-79 ◽  
Author(s):  
ROSS J. BALDESSARINI ◽  
WILLIAM R. BELL
Keyword(s):  
Blood Cells ◽  
White Blood Cells ◽  
Transferase Activity ◽  
Methyl Transferase

Phenylethanolamine-N-methyl transferase activity in the ground squirrel (Citellus citellus)

1973 ◽  
Vol 29 (7) ◽  
pp. 876-877 ◽  
Author(s):  
V. M. Petrović ◽  
D. Grippois ◽  
V. Janić ◽  
J. Roffi
Keyword(s):  
Ground Squirrel ◽  
Transferase Activity ◽  
Methyl Transferase
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