The influence of inhibition of catechol-O-methyl transferase or of monoamine oxidase on the extraneuronal metabolism of 3H-(?)-noradrenaline in the rat heart

1984 ◽  
Vol 327 (4) ◽  
pp. 285-292 ◽  
Author(s):  
U. Trendelenburg
Keyword(s):  
Monoamine Oxidase ◽  
Rat Heart ◽  
Methyl Transferase ◽  
Extraneuronal Metabolism

The effects of thyroid hormones on monoamine oxidase in the rat heart

1974 ◽  
Vol 26 (12) ◽  
pp. 921-930 ◽  
Author(s):  
G. A. LYLES ◽  
B. A. CALLINGHAM
Keyword(s):  
Monoamine Oxidase ◽  
Thyroid Hormones ◽  
Rat Heart

scholarly journals Dopamine in the Pathophysiology of Preeclampsia and Gestational Hypertension: Monoamine Oxidase (MAO) and Catechol-O-methyl Transferase (COMT) as Possible Mechanisms

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Wendy N. Phoswa
Keyword(s):  
Monoamine Oxidase ◽  
Gestational Hypertension ◽  
Morbidity And Mortality ◽  
Therapeutic Interventions ◽  
Hypertensive Disorders Of Pregnancy ◽  
Methyl Transferase ◽  
Hypertension In Pregnancy ◽  
Health Burden ◽  
Hypertensive Disorders ◽  
In Pregnancy

Purpose of the Review. Hypertension in pregnancy is the global health burden. Amongst the hypertensive disorders of pregnancy, preeclampsia and gestational hypertension are the world’s leading disorders that lead to both maternal and fetal morbidity and mortality. Recent Findings. Dopamine inactive metabolites, namely, monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT), have been reported to be associated with hypertensive disorders of pregnancy such preeclampsia and gestational hypertension. Summary. This review discusses the involvement of MAO and COMT in the pathophysiology of both conditions in order to have a better understanding on the pathogenesis of both conditions, suggesting promising therapeutic interventions and subsequently reducing maternal and fetal morbidity and mortality.

The Effect of Age on the Number of Monoamine Oxidase Active Centres in the Rat Heart

1978 ◽  
Vol 6 (5) ◽  
pp. 955-956 ◽  
Author(s):  
CHRISTOPHER J. FOWLER ◽  
BRIAN A. CALLINGHAM
Keyword(s):  
Monoamine Oxidase ◽  
Rat Heart ◽  
Effect Of Age ◽  
Active Centres

Noradrenaline and normetadrenaline metabolism in portal cirrhosis

1964 ◽  
Vol 207 (5) ◽  
pp. 1087-1094 ◽  
Author(s):  
McC. Goodall ◽  
Harold Alton ◽  
Martha Henry
Keyword(s):  
Monoamine Oxidase ◽  
Alcoholic Cirrhosis ◽  
Transferase Activity ◽  
Monoamine Oxidase Activity ◽  
Noradrenaline Metabolism ◽  
Portal Cirrhosis ◽  
Indwelling Catheter ◽  
Methyl Transferase ◽  
Metabolic Products ◽  
Sulfate Conjugate

Four patients with moderate to severe portal (alcoholic) cirrhosis were injected intravenously with dl-noradrenaline-2-C14. Urine was collected via an indwelling catheter at 10-min intervals for 1 hr and thereafter for 6 and 24 hr. The metabolic products of noradrenaline were separated, identified, and their radioactivity measured. The same subjects were also injected with dl-normetadrenaline-1-C14, the O-methylated metabolic product of noradrenaline, and the urine samples similarly processed. The results seem to indicate that in portal cirrhosis noradrenaline metabolism is altered. In the period immediately following the injection of noradrenaline there is a slight decrease in the catechol-O-methyl transferase activity but thereafter it is either unchanged or slightly increased. Further, the cirrhotic shows a distinct predilection for conjugating both noradrenaline and normetadrenaline. This is reflected by a significant increase in the sulfate conjugate of both of these compounds. The monoamine oxidase activity is decreased slightly throughout the collection periods. This is reflected by a decrease in the formation of 3-methoxy-4-hydroxymandelic acid following an injection of both noradrenaline and normetadrenaline.

Case-Control study of dopamine transporter-1, monoamine oxidase-B, and catechol-O-methyl transferase polymorphisms in Parkinson's disease

2002 ◽  
Vol 17 (6) ◽  
pp. 1305-1311 ◽  
Author(s):  
John L. Goudreau ◽  
Demetrius M. Maraganore ◽  
Matthew J. Farrer ◽  
Timothy G. Lesnick ◽  
Andrew B. Singleton ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Monoamine Oxidase ◽  
Dopamine Transporter ◽  
Case Control Study ◽  
Case Control ◽  
Monoamine Oxidase B ◽  
Methyl Transferase ◽  
Control Study

Monoamine Oxidase and Catechol-O-Methyl Transferase Activity inTetrahymena*

1977 ◽  
Vol 24 (3) ◽  
pp. 459-462 ◽  
Author(s):  
JEROME M. FELDMAN ◽  
JOAN M. ROCHE ◽  
J. J. BLUM
Keyword(s):  
Monoamine Oxidase ◽  
Transferase Activity ◽  
Methyl Transferase
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