The Polygenic Model

1997 ◽  
pp. 123-141
Author(s):  
Kenneth Lange
Keyword(s):  
Polygenic Model

scholarly journals A New Polygenic Model for Nonfamilial Colorectal Cancer Inheritance Based on the Genetic Architecture of the Azoxymethane-Induced Mouse Model

Genetics ◽  
2019 ◽  
Vol 214 (3) ◽  
pp. 691-702
Author(s):  
Anika C. Bissahoyo ◽  
Yuying Xie ◽  
Lynda Yang ◽  
R. Scott Pearsall ◽  
Daekee Lee ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mouse Model ◽  
Genetic Architecture ◽  
Inbred Strains ◽  
Genome Wide Association ◽  
Polygenic Resistance ◽  
Genetic Studies ◽  
Polygenic Model ◽  
Genome Wide ◽  
Dominant Characteristic

The azoxymethane model of colorectal cancer (CRC) was used to gain insights into the genetic heterogeneity of nonfamilial CRC. We observed significant differences in susceptibility parameters across 40 mouse inbred strains, with 6 new and 18 of 24 previously identified mouse CRC modifier alleles detected using genome-wide association analysis. Tumor incidence varied in F1 as well as intercrosses and backcrosses between resistant and susceptible strains. Analysis of inheritance patterns indicates that resistance to CRC development is inherited as a dominant characteristic genome-wide, and that susceptibility appears to occur in individuals lacking a large-effect, or sufficient numbers of small-effect, polygenic resistance alleles. Our results suggest a new polygenic model for inheritance of nonfamilial CRC, and that genetic studies in humans aimed at identifying individuals with elevated susceptibility should be pursued through the lens of absence of dominant resistance alleles rather than for the presence of susceptibility alleles.

scholarly journals Selection for recombination in a polygenic model – the mechanism

1988 ◽  
Vol 51 (1) ◽  
pp. 59-63 ◽  
Author(s):  
J. Maynard Smith
Keyword(s):  
Linkage Disequilibrium ◽  
Recombination Rate ◽  
Phenotypic Variability ◽  
Directional Selection ◽  
Polygenic Model ◽  
Infinite Population ◽  
Selection For ◽  
Repulsion Linkage

SummaryA polygenic model has been simulated in order to reveal the process whereby selection in an infinite population can lead to an increase in the frequency of alleles causing higher rates of recombination (CH alleles). Directional selection generates repulsion linkage disequilibrium (+ − + −), which is less strong in CH gametes (gametes carrying CH alleles). In consequence, CH gametes contribute greater phenotypic variability, and therefore respond more to directional selection: that is, they accumulate more selectively favoured alleles. CH alleles then increase in frequency by hitch-hiking. In contrast, normalizing selection, or frequent changes in the direction of selection, favour alleles for a low recombination rate.

scholarly journals Polygenic mutations in the cytotoxicity pathway increase susceptibility to develop HLH immunopathology in mice

Blood ◽  
2016 ◽  
Vol 127 (17) ◽  
pp. 2113-2121 ◽  
Author(s):  
Fernando E. Sepulveda ◽  
Alexandrine Garrigue ◽  
Sophia Maschalidi ◽  
Meriem Garfa-Traore ◽  
Gaël Ménasché ◽  
...  
Keyword(s):  
Polygenic Model ◽  
Key Points ◽  
Lymphocyte Cytotoxicity

Key Points The accumulation of monoallelic mutations in HLH-causing genes impairs lymphocyte cytotoxicity contributing to HLH immunopathology in mice. A polygenic model may account for some of the cases of secondary HLH observed in humans.

scholarly journals Polygenic model of DNA repair genetic polymorphisms in human breast cancer risk

2008 ◽  
Vol 29 (11) ◽  
pp. 2132-2138 ◽  
Author(s):  
Tasha R. Smith ◽  
Edward A. Levine ◽  
Rita I. Freimanis ◽  
Steven A. Akman ◽  
Glenn O. Allen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Repair ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Genetic Polymorphisms ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Polygenic Model

194 Multibreed Angus-Brahman genetic parameters and predictions for nine ultrasound and carcass traits using three genomic-polygenic models and one polygenic model

2017 ◽  
Vol 95 (suppl_4) ◽  
pp. 96-96
Author(s):  
M. A. Elzo ◽  
R. G. Mateescu ◽  
D. D. Johnson ◽  
T. L. Scheffler ◽  
J. M. Scheffler ◽  
...  
Keyword(s):  
Genetic Parameters ◽  
Carcass Traits ◽  
Polygenic Model

A Polygenic Model of the Metabolic Syndrome With Reduced Circulating and Intra-Adipose Glucocorticoid Action

Diabetes ◽  
2005 ◽  
Vol 54 (12) ◽  
pp. 3371-3378 ◽  
Author(s):  
N. M. Morton ◽  
V. Densmore ◽  
M. Wamil ◽  
L. Ramage ◽  
K. Nichol ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Polygenic Model ◽  
The Metabolic Syndrome ◽  
Glucocorticoid Action

Improved prediction of early-onset coronary artery disease using APOE ε4, BChE-K, PPARγ2 Pro12 and ENOS T-786C in a polygenic model

2006 ◽  
Vol 39 (2) ◽  
pp. 109-114 ◽  
Author(s):  
Bassam A. Nassar ◽  
Kenneth Rockwood ◽  
Susan A. Kirkland ◽  
Thomas P. Ransom ◽  
Sultan Darvesh ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Early Onset ◽  
Polygenic Model ◽  
Apoe Ε4 ◽  
Artery Disease
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