CSF as a Reflection of Cerebral Metabolism

1994 ◽  
pp. 35-42
Author(s):  
J. Bianchine ◽  
H. McConnell
Keyword(s):  
Cerebral Metabolism

2D NMR studies on muscle and cerebral metabolism in vivo

1994 ◽  
Vol 91 ◽  
pp. 697-703 ◽  
Author(s):  
B Gillet ◽  
BT Doan ◽  
C Verre-Sebrie ◽  
O Fedeli ◽  
JC Beloeil ◽  
...  
Keyword(s):  
Cerebral Metabolism ◽  
2D Nmr ◽  
Nmr Studies

scholarly journals Curbing action potential generation or ATP-synthase leads to a decrease in in-cell pyruvate dehydrogenase activity in rat cerebrum slices

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Benjamin Grieb ◽  
Sivaranjan Uppala ◽  
Gal Sapir ◽  
David Shaul ◽  
J. Moshe Gomori ◽  
...  
Keyword(s):  
Action Potential ◽  
Atp Synthase ◽  
Neural Activity ◽  
Pyruvate Dehydrogenase ◽  
Cerebral Metabolism ◽  
Neuronal Firing ◽  
Action Potential Generation ◽  
Potential Generation ◽  
Drastic Increase ◽  
Rat Cerebrum

AbstractDirect and real-time monitoring of cerebral metabolism exploiting the drastic increase in sensitivity of hyperpolarized 13C-labeled metabolites holds the potential to report on neural activity via in-cell metabolic indicators. Here, we followed the metabolic consequences of curbing action potential generation and ATP-synthase in rat cerebrum slices, induced by tetrodotoxin and oligomycin, respectively. The results suggest that pyruvate dehydrogenase (PDH) activity in the cerebrum is 4.4-fold higher when neuronal firing is unperturbed. The PDH activity was 7.4-fold reduced in the presence of oligomycin, and served as a pharmacological control for testing the ability to determine changes to PDH activity in viable cerebrum slices. These findings may open a path towards utilization of PDH activity, observed by magnetic resonance of hyperpolarized 13C-labeled pyruvate, as a reporter of neural activity.

Effects of stroke on local cerebral metabolism and perfusion: Mapping by emission computed tomography of18FDG and13NH3

1980 ◽  
Vol 8 (1) ◽  
pp. 47-60 ◽  
Author(s):  
David E. Kuhl ◽  
Michael E. Phelps ◽  
Arthur P. Kowell ◽  
E. Jeffrey Metter ◽  
Carl Selin ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Cerebral Metabolism ◽  
Emission Computed Tomography ◽  
Emission Computed

scholarly journals Clinical Factors Associated with Cerebral Metabolism in Term Neonates with Congenital Heart Disease

2017 ◽  
Vol 183 ◽  
pp. 67-73.e1 ◽  
Author(s):  
Anna Lonyai Harbison ◽  
Jodie K. Votava-Smith ◽  
Sylvia del Castillo ◽  
S. Ram Kumar ◽  
Vince Lee ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Cerebral Metabolism ◽  
Clinical Factors ◽  
Term Neonates ◽  
Factors Associated

scholarly journals Cerebral Metabolism is Influenced by Muscle Ischaemia During Exercise in Humans

2003 ◽  
Vol 88 (2) ◽  
pp. 297-302 ◽  
Author(s):  
Mads K. Dalsgaard ◽  
Lars Nybo ◽  
Yan Cai ◽  
Niels H. Secher
Keyword(s):  
Cerebral Metabolism ◽  
Muscle Ischaemia ◽  
Exercise In Humans

Reprint of: Resting cerebral metabolism correlates with skin conductance and functional brain activation during fear conditioning

2013 ◽  
Vol 92 (1) ◽  
pp. 26-35 ◽  
Author(s):  
Clas Linnman ◽  
Mohamed A. Zeidan ◽  
Roger K. Pitman ◽  
Mohammed R. Milad
Keyword(s):  
Fear Conditioning ◽  
Skin Conductance ◽  
Cerebral Metabolism ◽  
Brain Activation ◽  
Functional Brain

Thiamine (Vitamin B1)

2011 ◽  
Vol 16 (1) ◽  
pp. 12-20 ◽  
Author(s):  
Aviva Fattal-Valevski
Keyword(s):  
Cognitive Impairment ◽  
Cerebral Metabolism ◽  
Oxidant Stress ◽  
Vitamin B1 ◽  
Vitamin B ◽  
Deficient Diet ◽  
Common Cause ◽  
Korsakoff Syndrome ◽  
Reducing Substances ◽  
B Vitamin

Thiamine (vitamin B1) was the first B vitamin to have been identified. It serves as a cofactor for several enzymes involved in energy metabolism. The thiamine-dependent enzymes are important for the biosynthesis of neurotransmitters and for the production of reducing substances used in oxidant stress defenses, as well as for the synthesis of pentoses used as nucleic acid precursors. Thiamine plays a central role in cerebral metabolism. Its deficiency results in dry beriberi, a peripheral neuropathy, wet beriberi, a cardiomyopathy with edema and lactic acidosis, and Wernicke—Korsakoff syndrome, whose manifestations consist of nystagmus, ophthalmoplegia, and ataxia evolving into confusion, retrograde amnesia, cognitive impairment, and confabulation. Patients on a strict thiamine-deficient diet display a state of severe depletion within 18 days. The most common cause of thiamine deficiency in affluent countries is either alcoholism or malnutrition in nonalcoholic patients. Treatment by thiamine supplementation is beneficial for diagnostic and therapeutic purposes.

Sign in / Sign up

Export Citation Format

Share Document