Incomplete Proteolysis May Contribute to Lipofuscin Accumulation in the Retinal Pigment Epithelium

1990 ◽  
pp. 109-118 ◽  
Author(s):  
Martin L. Katz
Keyword(s):  
Retinal Pigment Epithelium ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Lipofuscin Accumulation

scholarly journals P 416 Lipofuscin accumulation in the retinal pigment epithelium and fatty acid diet

1995 ◽  
Vol 35 ◽  
pp. S234
Author(s):  
A. Garcia-Layana ◽  
J. Moreno ◽  
D. Aliseda ◽  
J.M. Munuera ◽  
D. Moya ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Retinal Pigment Epithelium ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Lipofuscin Accumulation ◽  
Acid Diet

scholarly journals The 5HT1a Receptor Agonist 8-Oh DPAT Induces Protection from Lipofuscin Accumulation and Oxidative Stress in the Retinal Pigment Epithelium

PLoS ONE ◽  
2012 ◽  
Vol 7 (4) ◽  
pp. e34468 ◽  
Author(s):  
Prajitha Thampi ◽  
Haripriya Vittal Rao ◽  
Sayak K. Mitter ◽  
Jun Cai ◽  
Haoyu Mao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Retinal Pigment Epithelium ◽  
Receptor Agonist ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
5Ht1a Receptor ◽  
Lipofuscin Accumulation ◽  
And Oxidative Stress

scholarly journals Zinc Deficiency Leads to Lipofuscin Accumulation in the Retinal Pigment Epithelium of Pigmented Rats

PLoS ONE ◽  
2011 ◽  
Vol 6 (12) ◽  
pp. e29245 ◽  
Author(s):  
Sylvie Julien ◽  
Antje Biesemeier ◽  
Despina Kokkinou ◽  
Oliver Eibl ◽  
Ulrich Schraermeyer
Keyword(s):  
Retinal Pigment Epithelium ◽  
Zinc Deficiency ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Lipofuscin Accumulation

High-voltage electron microscopy of subretinal scar formation

1992 ◽  
Vol 50 (1) ◽  
pp. 486-487
Author(s):  
G.E. Korte ◽  
M. Marko ◽  
G. Hageman
Keyword(s):  
Electron Microscopy ◽  
Monoclonal Antibody ◽  
Retinal Pigment Epithelium ◽  
Glial Cells ◽  
High Voltage ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Sodium Iodate ◽  
High Voltage Electron Microscopy ◽  
Voltage Electron

Sodium iodate iv. damages the retinal pigment epithelium (RPE) in rabbits. Where RPE does not regenerate (e.g., 1,2) Muller glial cells (MC) forma subretinal scar that replaces RPE. The MC response was studied by HVEM in 3D computer reconstructions of serial thick sections, made using the STEREC0N program (3), and the HVEM at the NYS Dept. of Health in Albany, NY. Tissue was processed for HVEM or immunofluorescence localization of a monoclonal antibody recognizing MG microvilli (4).

scholarly journals 4-(Phenylsulfanyl) Butan-2-One Attenuates the Inflammatory Response Induced by Amyloid-β Oligomers in Retinal Pigment Epithelium Cells

Marine Drugs ◽  
2020 ◽  
Vol 19 (1) ◽  
pp. 1
Author(s):  
Peeraporn Varinthra ◽  
Shun-Ping Huang ◽  
Supin Chompoopong ◽  
Zhi-Hong Wen ◽  
Ingrid Y. Liu
Keyword(s):  
Retinal Pigment Epithelium ◽  
Inflammatory Response ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Amyloid Β ◽  
Age Related Macular Degeneration ◽  
Epithelial Cell Line ◽  
Age Related ◽  
Tnf Α ◽  
Cox 2

Age-related macular degeneration (AMD) is a progressive eye disease that causes irreversible impairment of central vision, and effective treatment is not yet available. Extracellular accumulation of amyloid-beta (Aβ) in drusen that lie under the retinal pigment epithelium (RPE) has been reported as one of the early signs of AMD and was found in more than 60% of Alzheimer’s disease (AD) patients. Extracellular deposition of Aβ can induce the expression of inflammatory cytokines such as IL-1β, TNF-α, COX-2, and iNOS in RPE cells. Thus, finding a compound that can effectively reduce the inflammatory response may help the treatment of AMD. In this research, we investigated the anti-inflammatory effect of the coral-derived compound 4-(phenylsulfanyl) butan-2-one (4-PSB-2) on Aβ1-42 oligomer (oAβ1-42) added to the human adult retinal pigment epithelial cell line (ARPE-19). Our results demonstrated that 4-PSB-2 can decrease the elevated expressions of TNF-α, COX-2, and iNOS via NF-κB signaling in ARPE-19 cells treated with oAβ1-42 without causing any cytotoxicity or notable side effects. This study suggests that 4-PSB-2 is a promising drug candidate for attenuation of AMD.

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