A Primer to Angiotensin Peptide Isolation, Stability, and Analysis by Nano-Liquid Chromatography with Mass Detection

2017 ◽  
pp. 175-187 ◽  
Author(s):  
Mariola Olkowicz ◽  
Stefan Chlopicki ◽  
Ryszard T. Smolenski
Keyword(s):  
Liquid Chromatography ◽  
Mass Detection ◽  
Nano Liquid Chromatography ◽  
Angiotensin Peptide

scholarly journals Development and validation of a liquid chromatography-tandem mass spectrometric method for the determination of lenalidomide in human plasma and its application on bioequivalence studies

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
R. Gopinath ◽  
S. T. Narenderan ◽  
M. Kumar ◽  
B. Babu
Keyword(s):  
Liquid Chromatography ◽  
Human Plasma ◽  
Internal Standard ◽  
Spectrometric Method ◽  
Tandem Mass ◽  
Mass Spectrometric Method ◽  
Mass Detection ◽  
Triple Quadrupole Mass Spectrometer ◽  
Liquid Chromatography Tandem Mass ◽  
Tandem Mass Spectrometric

AbstractA simple, sensitive, and specific liquid chromatography-tandem mass spectrophotometry (LC-MS/MS) method was developed and validated for the quantification of lenalidomide in human plasma. The separation was carried out on a symmetry, C18, 5-μm (50 × 4.6 mm) column as stationary phase and with an isocratic mobile phase of 0.1% formic acid in water-methanol in the ratio of (15:85, v/v) at a flow rate of 0.5 mL/min. Protonated ions formed by electrospray ionization in the positive mode were used to detect analyte and fluconazole (internal standard). The mass detection was made by monitoring the fragmentation of m/z 260.1/148.8 for lenalidomide and m/z 307.1/238.0 for internal standard on a triple quadrupole mass spectrometer. The developed method was validated over the concentration range of 10–1000 ng/mL for lenalidomide in human plasma with a correlation coefficient (r2) was 0.9930. The accuracy and precision values obtained from six different sets of quality control samples analyzed on separate occasions ranged from 99.41 to 106.97% and 2.88 to 4.22%, respectively. Mean extraction recoveries were 98.06% and 88.78% for the analyte and IS, respectively. The developed method was successfully applied for analyzing lenalidomide in human plasma samples.

scholarly journals Towards in situ scopolamine analysis in beverages: bicolorimetric device vs portable nano liquid chromatography

Talanta ◽  
2021 ◽  
pp. 122406
Author(s):  
N. Jornet-Martínez ◽  
R. Herráez-Hernández ◽  
P. Campíns-Falcó
Keyword(s):  
Liquid Chromatography ◽  
Nano Liquid Chromatography

Phospholipids covalently attached to silica particles as stationary phase in nano-liquid chromatography

2012 ◽  
Vol 71 ◽  
pp. 1-10 ◽  
Author(s):  
Clara-Eugenia Baños ◽  
Susanne K. Wiedmer ◽  
Jan-Henrik Smått ◽  
Motolani Sakeye ◽  
Jana Lokajová ◽  
...  
Keyword(s):  
Liquid Chromatography ◽  
Stationary Phase ◽  
Silica Particles ◽  
Nano Liquid Chromatography

scholarly journals High-Resolution Nano-Liquid Chromatography with Tandem Mass Spectrometric Detection for the Bottom-Up Analysis of Complex Proteomic Samples

2018 ◽  
Vol 82 (1) ◽  
pp. 101-110 ◽  
Author(s):  
Magali Dams ◽  
José Luís Dores-Sousa ◽  
Robert-Jan Lamers ◽  
Achim Treumann ◽  
Sebastiaan Eeltink
Keyword(s):  
Liquid Chromatography ◽  
High Resolution ◽  
Mass Spectrometric ◽  
Mass Spectrometric Detection ◽  
Tandem Mass ◽  
Bottom Up ◽  
Nano Liquid Chromatography ◽  
Tandem Mass Spectrometric

Separation of basic compounds of pharmaceutical interest by using nano-liquid chromatography coupled with mass spectrometry

2007 ◽  
Vol 1150 (1-2) ◽  
pp. 252-258 ◽  
Author(s):  
Salvatore Fanali ◽  
Zeineb Aturki ◽  
Giovanni D’Orazio ◽  
Anna Rocco
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Basic Compounds ◽  
Nano Liquid Chromatography
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