Integrated Microarray-based Tools for Detection of Genomic DNA Damage and Repair Mechanisms

2017 ◽  
pp. 77-99 ◽  
Author(s):  
Patrick van Eijk ◽  
Yumin Teng ◽  
Mark R. Bennet ◽  
Katie E. Evans ◽  
James R. Powell ◽  
...  
Keyword(s):  
Dna Damage ◽  
Genomic Dna ◽  
Dna Damage And Repair ◽  
Repair Mechanisms

scholarly journals Arsenic Biotransformation as a Cancer Promoting Factor by Inducing DNA Damage and Disruption of Repair Mechanisms

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Victor D. Martinez ◽  
Emily A. Vucic ◽  
Marta Adonis ◽  
Lionel Gil ◽  
Wan L. Lam
Keyword(s):  
Dna Damage ◽  
Drinking Water ◽  
Repair Process ◽  
Dna Methyltransferases ◽  
Health Concern ◽  
Dna Damage And Repair ◽  
Repair Mechanisms ◽  
Contaminated Drinking Water ◽  
High Concentrations ◽  
Epigenetic Patterns

Chronic exposure to arsenic in drinking water poses a major global health concern. Populations exposed to high concentrations of arsenic-contaminated drinking water suffer serious health consequences, including alarming cancer incidence and death rates. Arsenic is biotransformed through sequential addition of methyl groups, acquired from s-adenosylmethionine (SAM). Metabolism of arsenic generates a variety of genotoxic and cytotoxic species, damaging DNA directly and indirectly, through the generation of reactive oxidative species and induction of DNA adducts, strand breaks and cross links, and inhibition of the DNA repair process itself. Since SAM is the methyl group donor used by DNA methyltransferases to maintain normal epigenetic patterns in all human cells, arsenic is also postulated to affect maintenance of normal DNA methylation patterns, chromatin structure, and genomic stability. The biological processes underlying the cancer promoting factors of arsenic metabolism, related to DNA damage and repair, will be discussed here.

scholarly journals Strategies for the evaluation of DNA damage and repair mechanisms in cancer

2017 ◽  
Vol 13 (6) ◽  
pp. 3982-3988 ◽  
Author(s):  
Gabriela Figueroa-González ◽  
Carlos Pérez-Plasencia
Keyword(s):  
Dna Damage ◽  
Dna Damage And Repair ◽  
Repair Mechanisms

Role of DNA damage and repair mechanisms in uterine fibroid/leiomyomas: a review

2020 ◽  
Author(s):  
Sneh M Toprani ◽  
Varsha Kelkar Mane
Keyword(s):  
Dna Damage ◽  
Molecular Mechanisms ◽  
Healthcare Sector ◽  
Clinical Aspects ◽  
Dna Damage And Repair ◽  
Myometrial Cells ◽  
Mutational Burden ◽  
The World ◽  
Repair Mechanisms

Abstract There has been a significant annual increase in the number of cases of uterine leiomyomas or fibroids (UF) among women of all races and ages across the world. A fortune is usually spent by the healthcare sector for fibroid-related treatments and management. Molecular studies have established the higher mutational heterogeneity in UF as compared to normal myometrial cells. The contribution of DNA damage and defects in repair responses further increases the mutational burden on the cells. This in turn leads to genetic instability, associated with cancer risk and other adverse reproductive health outcomes. Such and many more growing bodies of literature have highlighted the genetic/molecular, biochemical and clinical aspects of UF; none the less there appear to be a lacuna bridging the bench to bed gap in addressing and preventing this disease. Presented here is an exhaustive review of not only the molecular mechanisms underlying the predisposition to the disease but also possible strategies to effectively diagnose, prevent, manage, and treat this disease.

Hexavalent Chromium-Induced DNA Damage and Repair Mechanisms

2008 ◽  
Vol 23 (1) ◽  
Author(s):  
Sandra S. Wise ◽  
Amie L. Holmes ◽  
John Pierce Wise, Sr.
Keyword(s):  
Dna Damage ◽  
Hexavalent Chromium ◽  
Dna Damage And Repair ◽  
Repair Mechanisms

scholarly journals DNA Damage and Repair in Plants under Ultraviolet and Ionizing Radiations

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Sarvajeet S. Gill ◽  
Naser A. Anjum ◽  
Ritu Gill ◽  
Manoranjan Jha ◽  
Narendra Tuteja
Keyword(s):  
Dna Damage ◽  
Future Research ◽  
Water Radiolysis ◽  
Dna Damage And Repair ◽  
Dna Repair Mechanisms ◽  
Dna Damaging Agents ◽  
Repair Mechanisms ◽  
Current Context ◽  
Ionizing Radiations ◽  
Cellular Components

Being sessile, plants are continuously exposed to DNA-damaging agents present in the environment such as ultraviolet (UV) and ionizing radiations (IR). Sunlight acts as an energy source for photosynthetic plants; hence, avoidance of UV radiations (namely, UV-A, 315–400 nm; UV-B, 280–315 nm; and UV-C, <280 nm) is unpreventable. DNA in particular strongly absorbs UV-B; therefore, it is the most important target for UV-B induced damage. On the other hand, IR causes water radiolysis, which generates highly reactive hydroxyl radicals (OH•) and causes radiogenic damage to important cellular components. However, to maintain genomic integrity under UV/IR exposure, plants make use of several DNA repair mechanisms. In the light of recent breakthrough, the current minireview (a) introduces UV/IR and overviews UV/IR-mediated DNA damage products and (b) critically discusses the biochemistry and genetics of major pathways responsible for the repair of UV/IR-accrued DNA damage. The outcome of the discussion may be helpful in devising future research in the current context.

2: Platinum-induced DNA damage and repair mechanisms in non-small cell lung cancer

Lung Cancer ◽  
2015 ◽  
Vol 87 ◽  
pp. S1
Author(s):  
Y. He ◽  
K.J. O'Byrne ◽  
S. Cuffe ◽  
S. Finn ◽  
M. Barr
Keyword(s):  
Lung Cancer ◽  
Dna Damage ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Dna Damage And Repair ◽  
Repair Mechanisms

The Significance of DNA Damage and Repair Mechanisms in Health Risk Assessment

1990 ◽  
pp. 225-232
Author(s):  
Lorenz Rhomberg ◽  
Vicki L. Dellarco ◽  
William H. Farland ◽  
Roger S. Cortesi
Keyword(s):  
Risk Assessment ◽  
Dna Damage ◽  
Health Risk ◽  
Health Risk Assessment ◽  
Dna Damage And Repair ◽  
Repair Mechanisms
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