Thallium Flux Assay for Measuring the Activity of Monovalent Cation Channels and Transporters

2017 ◽  
pp. 105-114 ◽  
Author(s):  
C. David Weaver
Keyword(s):  
Monovalent Cation ◽  
Cation Channels

Similarities of viral proteins to toxins that interact with monovalent cation channels

AIDS ◽  
1991 ◽  
Vol 5 (11) ◽  
pp. 1381-1384 ◽  
Author(s):  
Robert F. Garry ◽  
Jens J. Kort ◽  
Friedrich Koch-Nolte ◽  
Gebhard Koch
Keyword(s):  
Viral Proteins ◽  
Monovalent Cation ◽  
Cation Channels

Cation channels of the TRPC family contribute to development of nephropathy and retinopathy in the STZ model

2015 ◽  
Vol 10 (S 01) ◽  
Author(s):  
M Freichel ◽  
D Schumacher ◽  
C Matka ◽  
I Mathar ◽  
U Kriebs ◽  
...  
Keyword(s):  
Cation Channels

The Role of TRPV4 Cation Channels in Regulation of Phenylephrine-Induced Contraction of Rat Pulmonary Artery

2017 ◽  
Vol 8 (2) ◽  
pp. 121-130
Author(s):  
Dariia Dryn ◽  
Mariia Melnyk ◽  
Ihor Kizub ◽  
Hongzhen Hu ◽  
Anatoly I. Soloviev ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
Cation Channels

Cyclopiazonic acid stimulates Ca2+ influx through non-specific cation channels in endothelial cells

1994 ◽  
Vol 251 (2-3) ◽  
pp. 119-125 ◽  
Author(s):  
He Zhang ◽  
Masato Inazu ◽  
Bryce Weir ◽  
Michael Buchanan ◽  
Ed Daniel
Keyword(s):  
Endothelial Cells ◽  
Cyclopiazonic Acid ◽  
Cation Channels

scholarly journals Endolysosomal Cation Channels and MITF in Melanocytes and Melanoma

Biomolecules ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1021
Author(s):  
Carla Abrahamian ◽  
Christian Grimm
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Transcription Factor ◽  
Convincing Evidence ◽  
Signaling Cascades ◽  
Cation Channels ◽  
Pore Channel ◽  
Different Types ◽  
Canonical Wnt ◽  
The Relationship

Microphthalmia-associated transcription factor (MITF) is the principal transcription factor regulating pivotal processes in melanoma cell development, growth, survival, proliferation, differentiation and invasion. In recent years, convincing evidence has been provided attesting key roles of endolysosomal cation channels, specifically TPCs and TRPMLs, in cancer, including breast cancer, glioblastoma, bladder cancer, hepatocellular carcinoma and melanoma. In this review, we provide a gene expression profile of these channels in different types of cancers and decipher their roles, in particular the roles of two-pore channel 2 (TPC2) and TRPML1 in melanocytes and melanoma. We specifically discuss the signaling cascades regulating MITF and the relationship between endolysosomal cation channels, MAPK, canonical Wnt/GSK3 pathways and MITF.

scholarly journals TRPM4 in Cancer—A New Potential Drug Target

Biomolecules ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 229
Author(s):  
Anna Borgström ◽  
Christine Peinelt ◽  
Paulina Stokłosa
Keyword(s):  
Anticancer Drug ◽  
Drug Target ◽  
Transient Receptor Potential ◽  
Human Cancer ◽  
Receptor Potential ◽  
B Cell Lymphoma ◽  
Underlying Mechanism ◽  
Monovalent Cation ◽  
Transient Receptor Potential Melastatin ◽  
And Migration

Transient receptor potential melastatin 4 (TRPM4) is widely expressed in various organs and associated with cardiovascular and immune diseases. Lately, the interest in studies on TRPM4 in cancer has increased. Thus far, TRPM4 has been investigated in diffuse large B-cell lymphoma, prostate, colorectal, liver, breast, urinary bladder, cervical, and endometrial cancer. In several types of cancer TRPM4 is overexpressed and contributes to cancer hallmark functions such as increased proliferation and migration and cell cycle shift. Hence, TRPM4 is a potential prognostic cancer marker and a promising anticancer drug target candidate. Currently, the underlying mechanism by which TRPM4 contributes to cancer hallmark functions is under investigation. TRPM4 is a Ca2+-activated monovalent cation channel, and its ion conductivity can decrease intracellular Ca2+ signaling. Furthermore, TRPM4 can interact with different partner proteins. However, the lack of potent and specific TRPM4 inhibitors has delayed the investigations of TRPM4. In this review, we summarize the potential mechanisms of action and discuss new small molecule TRPM4 inhibitors, as well as the TRPM4 antibody, M4P. Additionally, we provide an overview of TRPM4 in human cancer and discuss TRPM4 as a diagnostic marker and anticancer drug target.

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