scholarly journals Modulation of Lung Epithelial Cell Function Using Conditional and Inducible Transgenic Approaches

2018 ◽  
pp. 169-201
Author(s):  
Adrianne L. Stefanski ◽  
Dorota S. Raclawska ◽  
Christopher M. Evans
Keyword(s):  
Epithelial Cell ◽  
Cell Function ◽  
Lung Epithelial Cell ◽  
Lung Epithelial

scholarly journals OLFM4 Regulates Lung Epithelial Cell Function in Sepsis-Associated ARDS/ALI via LDHA-Mediated NF-κB Signaling

2021 ◽  
Vol Volume 14 ◽  
pp. 7035-7051
Author(s):  
Fangchen Gong ◽  
Ranran Li ◽  
Xiangtao Zheng ◽  
Weiwei Chen ◽  
Yanjun Zheng ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cell Function ◽  
Lung Epithelial Cell ◽  
Lung Epithelial

scholarly journals cis-acting elements that confer lung epithelial cell expression of the CC10 gene.

1992 ◽  
Vol 267 (21) ◽  
pp. 14703-14712
Author(s):  
B.R. Stripp ◽  
P.L. Sawaya ◽  
D.S. Luse ◽  
K.A. Wikenheiser ◽  
S.E. Wert ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Lung Epithelial Cell ◽  
Cis Acting ◽  
Lung Epithelial ◽  
Cell Expression

scholarly journals SARS-CoV-2 activates lung epithelial cell proinflammatory signaling and leads to immune dysregulation in COVID-19 patients

EBioMedicine ◽  
2021 ◽  
Vol 70 ◽  
pp. 103500
Author(s):  
Huarong Chen ◽  
Weixin Liu ◽  
Yifei Wang ◽  
Dabin Liu ◽  
Liuyang Zhao ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Immune Dysregulation ◽  
Lung Epithelial Cell ◽  
Lung Epithelial

Transgenic models for study of pulmonary development and disease

1994 ◽  
Vol 267 (5) ◽  
pp. L489-L497 ◽  
Author(s):  
S. W. Glasser ◽  
T. R. Korfhagen ◽  
S. E. Wert ◽  
J. A. Whitsett
Keyword(s):  
Epithelial Cell ◽  
Animal Models ◽  
Gene Targeting ◽  
Transgenic Mouse ◽  
Embryonic Stem ◽  
Lung Epithelial Cell ◽  
Major Advance ◽  
Cis Acting ◽  
Lung Epithelial

This review summarizes progress in the application of transgenic mouse technology to the study of lung development and disease. Since advances in molecular genetics have greatly facilitated the isolation of cDNA and genes, our ability to readily assess roles of both normal and mutated genes in transgenic mouse in vivo represents a major advance, bridging molecular biology and whole animal physiology. Strategies have been developed in which lung epithelial cell promoter elements are used to drive normal or mutated genes into specific subsets of respiratory epithelial cells in the lungs of developing and mature transgenic mice. These mice have been used to elucidate the cis-acting elements controlling lung epithelial cell gene expression, to discern the role of specific polypeptides in lung morphogenesis and tumorigenesis, and to create animal models of pulmonary disease. The ability to mutate genes at their precise chromosomal locations through gene targeting in embryonic stem cells has lead to the production of animal models of lung diseases such as cystic fibrosis. Both gene insertion and gene targeting create permanent mouse lines that pass the modified gene to their progeny, providing animals for the study of the pathogenesis and treatment of pulmonary disorders.

TMEM16A protein attenuates lipopolysaccharide-mediated inflammatory response of human lung epithelial cell line A549

2014 ◽  
Vol 40 (5) ◽  
pp. 237-250 ◽  
Author(s):  
Aili Zhang ◽  
Xixin Yan ◽  
Honglin Li ◽  
Zhenfang Gu ◽  
Peng Zhang ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Inflammatory Response ◽  
Cell Line ◽  
Human Lung ◽  
Lung Epithelial Cell ◽  
Epithelial Cell Line ◽  
Human Lung Epithelial Cell ◽  
Lung Epithelial

scholarly journals Sirtuin 1 Promotes Hyperoxia-Induced Lung Epithelial Cell Death Independent of NF-E2–Related Factor 2 Activation

2016 ◽  
Vol 54 (5) ◽  
pp. 697-706 ◽  
Author(s):  
Haranatha R. Potteti ◽  
Subbiah Rajasekaran ◽  
Senthilkumar B. Rajamohan ◽  
Chandramohan R. Tamatam ◽  
Narsa M. Reddy ◽  
...  
Keyword(s):  
Cell Death ◽  
Epithelial Cell ◽  
Lung Epithelial Cell ◽  
Sirtuin 1 ◽  
Related Factor ◽  
Lung Epithelial ◽  
Epithelial Cell Death
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