Production and Characterization of Chemically Cross-Linked Collagen Scaffolds

2019 ◽  
pp. 23-38 ◽  
Author(s):  
Ignacio Sallent ◽  
Héctor Capella-Monsonís ◽  
Dimitrios I. Zeugolis
Keyword(s):  
Collagen Scaffolds

scholarly journals Longitudinal in vivo micro-CT-based approach allows spatio-temporal characterization of fracture healing patterns and assessment of biomaterials in mouse femur defect models

2020 ◽  
Author(s):  
Esther Wehrle ◽  
Duncan C Tourolle né Betts ◽  
Gisela A Kuhn ◽  
Erica Floreani ◽  
Malavika H Nambiar ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Healing Process ◽  
Micro Ct ◽  
Micro Computed Tomography ◽  
Collagen Scaffolds ◽  
Non Union ◽  
Spatio Temporal ◽  
Large Bone

AbstractThorough preclinical evaluation of novel biomaterials for treatment of large bone defects is essential prior to clinical application. Using in vivo micro-computed tomography (micro-CT) and mouse femoral defect models with different defect sizes, we were able to detect spatio-temporal healing patterns indicative of physiological and impaired healing in three defect sub-volumes and the adjacent cortex. The time-lapsed in vivo micro-CT-based approach was then applied to evaluate the bone regeneration potential of biomaterials using collagen and BMP-2 as test materials. Both collagen and BMP-2 treatment led to distinct changes in bone turnover in the different healing phases. Despite increased periosteal bone formation, 87.5% of the defects treated with collagen scaffolds resulted in non-unions. Additional BMP-2 application significantly accelerated the healing process and increased the union rate to 100%. This study further shows potential of time-lapsed in vivo micro-CT for capturing spatio-temporal deviations preceding non-union formation and how this can be prevented by application of biomaterials.This study therefore supports the application of longitudinal in vivo micro-CT for discrimination of normal and disturbed healing patterns and for the spatio-temporal characterization of the bone regeneration capacity of biomaterials.

Synthesis and Characterization of Collagen Scaffolds Reinforced by Eggshell Derived Hydroxyapatite for Tissue Engineering

2015 ◽  
Vol 15 (1) ◽  
pp. 504-509 ◽  
Author(s):  
Sanosh Kunjalukkal Padmanabhan ◽  
Luca Salvatore ◽  
Francesca Gervaso ◽  
Massimo Catalano ◽  
Antonietta Taurino ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Synthesis And Characterization ◽  
Collagen Scaffolds

scholarly journals 3D Characterization of Collagen Remodeling in Cell-seeded Collagen Scaffolds via Polarization Second Harmonic Generation

2020 ◽  
Author(s):  
D Xydias ◽  
G Ziakas ◽  
Sotiris Psilodimitrakopoulos ◽  
Andreas Lemonis ◽  
E Bagli ◽  
...  
Keyword(s):  
Second Harmonic Generation ◽  
Harmonic Generation ◽  
Second Harmonic ◽  
Collagen Scaffolds ◽  
Collagen Remodeling

scholarly journals Characterization of the physical and mechanical properties of femoral bone defects filled with polyanionic collagen scaffolds in ovariectomized rats

2010 ◽  
Vol 13 (2) ◽  
pp. 239-244 ◽  
Author(s):  
Marcelo Rodrigues Cunha ◽  
Arnaldo Rodrigues Santos Jr ◽  
Leandro Petinari ◽  
Gilberto Goissis ◽  
Keico Okino Nonaka ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Physical And Mechanical Properties ◽  
Bone Defects ◽  
Ovariectomized Rats ◽  
Femoral Bone ◽  
Collagen Scaffolds

scholarly journals Physico-chemical characterization of collagen scaffolds for tissue engineering

2016 ◽  
Vol 14 (1) ◽  
pp. 77-85 ◽  
Author(s):  
B.H. León-Mancilla ◽  
M.A. Araiza-Téllez ◽  
J.O. Flores-Flores ◽  
M.C. Piña-Barba
Keyword(s):  
Tissue Engineering ◽  
Chemical Characterization ◽  
Collagen Scaffolds ◽  
Physico Chemical

scholarly journals Spatio-temporal characterization of fracture healing patterns and assessment of biomaterials by time-lapsed in vivo micro-computed tomography

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Esther Wehrle ◽  
Duncan C. Tourolle né Betts ◽  
Gisela A. Kuhn ◽  
Erica Floreani ◽  
Malavika H. Nambiar ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Bone Regeneration ◽  
Healing Process ◽  
Micro Ct ◽  
Micro Computed Tomography ◽  
Collagen Scaffolds ◽  
Non Union ◽  
Spatio Temporal

AbstractThorough preclinical evaluation of functionalized biomaterials for treatment of large bone defects is essential prior to clinical application. Using in vivo micro-computed tomography (micro-CT) and mouse femoral defect models with different defect sizes, we were able to detect spatio-temporal healing patterns indicative of physiological and impaired healing in three defect sub-volumes and the adjacent cortex. The time-lapsed in vivo micro-CT-based approach was then applied to evaluate the bone regeneration potential of functionalized biomaterials using collagen and bone morphogenetic protein (BMP-2). Both collagen and BMP-2 treatment led to distinct changes in bone turnover in the different healing phases. Despite increased periosteal bone formation, 87.5% of the defects treated with collagen scaffolds resulted in non-unions. Additional BMP-2 application significantly accelerated the healing process and increased the union rate to 100%. This study further shows potential of time-lapsed in vivo micro-CT for capturing spatio-temporal deviations preceding non-union formation and how this can be prevented by application of functionalized biomaterials. This study therefore supports the application of longitudinal in vivo micro-CT for discrimination of normal and disturbed healing patterns and for the spatio-temporal characterization of the bone regeneration capacity of functionalized biomaterials.

scholarly journals Development and characterization of porous functionalized collagen scaffolds for delivery of FGF-2

2014 ◽  
Vol 30 (3) ◽  
pp. 216-222 ◽  
Author(s):  
Ia. O. Pokholenko ◽  
M. D. Chetyrkina ◽  
L. V. Dubey ◽  
I. Ya. Dubey ◽  
O. V. Moshynets ◽  
...  
Keyword(s):  
Collagen Scaffolds
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