Nucleic Acid Aptamers as Emerging Tools for Diagnostics and Theranostics

2019 ◽  
pp. 201-221
Author(s):  
Ruchi Mutreja ◽  
Shahnawaz Ahmad Baba ◽  
Naveen Kumar Navani
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acid Aptamers

Nucleic Acid Aptamers as Novel Class of Therapeutics to Mitigate Alzheimer’s Disease Pathology

2013 ◽  
Vol 10 (4) ◽  
pp. 442-448 ◽  
Author(s):  
Rudi K. Tannenberg ◽  
Hadi Al. Shamaileh ◽  
Lasse H. Lauridsen ◽  
Jagat R. Kanwar ◽  
Peter R. Dodd ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Nucleic Acid ◽  
Nucleic Acid Aptamers

scholarly journals Chemical conjugation of nucleic acid aptamers and synthetic polymers

2021 ◽  
Author(s):  
Maria Nerantzaki ◽  
Capucine Loth ◽  
Jean-Francois Lutz
Keyword(s):  
Nucleic Acid ◽  
Synthetic Polymers ◽  
Specific Sequence ◽  
Biological Targets ◽  
Nucleic Acid Aptamers ◽  
Chemical Conjugation ◽  
Sequence Dependent

Nucleic acid aptamers are chemically-synthesized single-stranded oligonucleotides that fold into specific sequence-dependent configurations. Due to their exceptional recognition properties towards a variety of biological targets, they find applications in many...

scholarly journals Hybrid-Type SELEX for the Selection of Artificial Nucleic Acid Aptamers Exhibiting Cell Internalization Activity

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 888
Author(s):  
Hiro Uemachi ◽  
Yuuya Kasahara ◽  
Keisuke Tanaka ◽  
Takumi Okuda ◽  
Yoshihiro Yoneda ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Surface Protein ◽  
Functional Screening ◽  
Nucleic Acid Aptamers ◽  
Hybrid Type ◽  
Cell Internalization ◽  
Promising Target ◽  
A Cell ◽  
Exponential Enrichment

Nucleic acid aptamers have attracted considerable attention as next-generation pharmaceutical agents and delivery vehicles for small molecule drugs and therapeutic oligonucleotides. Chemical modification is an effective approach for improving the functionality of aptamers. However, the process of selecting appropriately modified aptamers is laborious because of many possible modification patterns. Here, we describe a hybrid-type systematic evolution of ligands by exponential enrichment (SELEX) approach for the generation of the artificial nucleic acid aptamers effective against human TROP2, a cell surface protein identified by drug discovery as a promising target for cancer therapy. Capillary electrophoresis SELEX was used for the pre-screening of multiple modified nucleic acid libraries and enrichment of TROP2 binding aptamers in the first step, followed by functional screening using cell-SELEX in the second step for the generation of cell-internalizing aptamers. One representative aptamer, Tac-B1, had a nanomolar-level affinity to human TROP2 and exhibited elevated capacity for internalization by cells. Because of the growing interest in the application of aptamers for drug delivery, our hybrid selection approach has great potential for the generation of functional artificial nucleic acid aptamers with ideal modification patterns in vitro.

scholarly journals Molecular Imaging with Nucleic Acid Aptamers

2011 ◽  
Vol 18 (27) ◽  
pp. 4195-4205 ◽  
Author(s):  
H. Hong ◽  
S. Goel ◽  
Y. Zhang ◽  
W. Cai
Keyword(s):  
Nucleic Acid ◽  
Molecular Imaging ◽  
Nucleic Acid Aptamers

Improved Anti-Prion Nucleic Acid Aptamers by Incorporation of Chemical Modifications

2020 ◽  
Vol 30 (6) ◽  
pp. 414-421 ◽  
Author(s):  
Jussara Amato ◽  
Tsukasa Mashima ◽  
Yuji O. Kamatari ◽  
Kazuo Kuwata ◽  
Ettore Novellino ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Chemical Modifications ◽  
Nucleic Acid Aptamers

scholarly journals Research on Targeted Thermal Effect of Molybdenum Disulfide Nanosheets Modified by Nucleic Acid Aptamers

2020 ◽  
Vol 185 ◽  
pp. 04003
Author(s):  
Bo pang ◽  
Lihong Jin ◽  
Liying Wang
Keyword(s):  
Nucleic Acid ◽  
Molybdenum Disulfide ◽  
Therapeutic Effect ◽  
Photothermal Therapy ◽  
Effective Concentration ◽  
Tumor Treatment ◽  
Nucleic Acid Aptamers ◽  
Low Toxicity ◽  
Good Biocompatibility ◽  
Molybdenum Disulfide Nanosheets

In this paper, the surface of molybdenum disulfide nanosheets synthesized by hydrothermal method was modified with bovine serum albumin (BSA) and nucleic acid aptamers in order to construct a photothermal system with high target recognition, stable size, good biocompatibility and low toxicity Nano material molybdenum disulfide; Under 808 nm laser irradiation, suitable functionalized molybdenum disulfide nanosheets can produce singlet oxygen at an effective concentration for photodynamic therapy, and at the same time, photothermal therapy can also be used to achieve synergistic therapy and the therapeutic effect is more excellent. This shows that such functionalized molybdenum disulfide nanosheets have excellent therapeutic effect and great potential in tumor treatment.

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