Stem Cell and Neuron Co-cultures for the Study of Nerve Regeneration

2010 ◽  
pp. 115-127 ◽  
Author(s):  
Paul J. Kingham ◽  
Cristina Mantovani ◽  
Giorgio Terenghi
Keyword(s):  
Stem Cell ◽  
Nerve Regeneration

New nerve regeneration strategy combining laminin-coated chitosan conduits and stem cell therapy

2013 ◽  
Vol 9 (5) ◽  
pp. 6606-6615 ◽  
Author(s):  
Sung-Hao Hsu ◽  
Wen-Chun Kuo ◽  
Yu-Tzu Chen ◽  
Chen-Tung Yen ◽  
Ying-Fang Chen ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Therapy ◽  
Nerve Regeneration ◽  
Stem Cell Therapy ◽  
Regeneration Strategy

Growth factor and stem cell enhanced conduits in peripheral nerve regeneration and repair

2008 ◽  
Vol 30 (10) ◽  
pp. 1030-1038 ◽  
Author(s):  
Stephen W. P. Kemp ◽  
Sarah K. Walsh ◽  
Rajiv Midha
Keyword(s):  
Stem Cell ◽  
Growth Factor ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration

Stem Cell-Based Approaches to Improve Nerve Regeneration: Potential Implications for Reconstructive Transplantation?

2014 ◽  
Vol 63 (1) ◽  
pp. 15-30 ◽  
Author(s):  
Saami Khalifian ◽  
Karim A. Sarhane ◽  
Markus Tammia ◽  
Zuhaib Ibrahim ◽  
Hai-Quan Mao ◽  
...  
Keyword(s):  
Stem Cell ◽  
Nerve Regeneration ◽  
Regeneration Potential ◽  
Reconstructive Transplantation

scholarly journals Insights into the Effects of the Dental Stem Cell Secretome on Nerve Regeneration: Towards Cell-Free Treatment

2019 ◽  
Vol 2019 ◽  
pp. 1-19 ◽  
Author(s):  
Rohaina Che Man ◽  
Nadiah Sulaiman ◽  
Ruszymah Bt Hj Idrus ◽  
Shahrul Hisham Zainal Ariffin ◽  
Rohaya Megat Abdul Wahab ◽  
...  
Keyword(s):  
Stem Cell ◽  
Data Collection ◽  
Nerve Regeneration ◽  
Cell Delivery ◽  
Inclusion Criteria ◽  
Regeneration Potential ◽  
Free Treatment ◽  
Dental Stem Cell

Cell-free treatment is emerging as an alternative to cell delivery to promote endogenous regeneration using cell-derived factors. The purpose of this article was to systematically review studies of the effects of the dental stem cell secretome on nerve regeneration. PubMed and Scopus databases were used where searched and related studies were selected. The primary search identified 36 articles with the utilized keywords; however, only 13 articles met the defined inclusion criteria. Eight out of thirteen articles included in vivo and in vitro studies. We classified the dental stem cell-derived secretome with its nerve regeneration potential. All studies demonstrated that dental stem cell-derived factors promote neurotrophic effects that can mechanistically stimulate nerve regeneration in neurodegenerative diseases and nerve injury. This data collection will enable researchers to gather information to create a precise formulation for future prescribed treatments.

scholarly journals Nanofibrous scaffolds for the guidance of stem cell-derived neurons for auditory nerve regeneration

PLoS ONE ◽  
2017 ◽  
Vol 12 (7) ◽  
pp. e0180427 ◽  
Author(s):  
Sandra Hackelberg ◽  
Samuel J. Tuck ◽  
Long He ◽  
Arjun Rastogi ◽  
Christina White ◽  
...  
Keyword(s):  
Stem Cell ◽  
Nerve Regeneration ◽  
Auditory Nerve ◽  
Nanofibrous Scaffolds

scholarly journals Effect of Systemic Adipose-derived Stem Cell Therapy on Functional Nerve Regeneration in a Rodent Model

2020 ◽  
Vol 8 (7) ◽  
pp. e2953
Author(s):  
Riccardo Schweizer ◽  
Jonas T. Schnider ◽  
Paolo M. Fanzio ◽  
Wakako Tsuji ◽  
Nataliya Kostereva ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Therapy ◽  
Nerve Regeneration ◽  
Stem Cell Therapy ◽  
Rodent Model ◽  
Adipose Derived Stem Cell

Peripheral nerve injury therapeutics, including electrical stimulation, stem cell treatments, and synthetic neural scaffolds, have shown promising preclinical and even clinical results with potential regenerative treatment

2021 ◽  
Author(s):  
Moataz Dowaidar
Keyword(s):  
Stem Cell ◽  
Electrical Stimulation ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Functional Recovery ◽  
Peripheral Nerve Regeneration ◽  
Clinical Results ◽  
Preclinical Research ◽  
Cell Therapies ◽  
Nerve Recovery

In the U.S., peripheral nerve injuries (PNI) harm about 22 million people. The most frequent causes and types of PNI vary by demography (civilians vs. military, geography/country). After crush injuries, functional recovery is better than after transections, and better after distal injuries than proximal ones. Despite advancements in microsurgical treatments, severe PNIs remain connected to slow recovery. This review highlights new peripheral nerve regeneration approaches (e.g. electrical stimulation, cell therapies), which may lead to a shift in PNI therapeutic paradigms in conjunction with neurotrophic agents and breakthroughs in bioscaffold engineering. It also examines how synthetic neural scaffolds can aid with peripheral nerve recovery, as well as the next generation of biomimetic neural scaffolding that can aid in tissue regeneration. Neurotrophic factor-enriched neural scaffolds, stem cell treatments, and electrical stimulation have shown promising preclinical and even clinical results. The future of peripheral nerve regeneration is bright, since a combination of the aforementioned treatments may have a synergistic impact on nerve regeneration and functional recovery in patients with PNI. Stem cell technology is improving and evolving, and it has been explored through a number of methods in preclinical research for peripheral nerve regeneration. Electrical stimulation is another interesting potential treatment for PNI that may be used to stimulate axon regeneration.

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