In Vivo Quantification of Metastatic Tumor Cell Adhesion in the Pulmonary Microvasculature

2013 ◽  
pp. 89-101
Author(s):  
F. Bartsch ◽  
M. L. Kang ◽  
S. T. Mees ◽  
J. Haier ◽  
P. Gassmann
Keyword(s):  
Cell Adhesion ◽  
Tumor Cell ◽  
Metastatic Tumor ◽  
Tumor Cell Adhesion ◽  
Metastatic Tumor Cell

Integrity of actin fibers and microtubules influences metastatic tumor cell adhesion

2004 ◽  
Vol 299 (1) ◽  
pp. 236-247 ◽  
Author(s):  
Timo Korb ◽  
Kerstin Schlüter ◽  
Andreas Enns ◽  
Hans-Ulrich Spiegel ◽  
Norbert Senninger ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Tumor Cell ◽  
Metastatic Tumor ◽  
Tumor Cell Adhesion ◽  
Metastatic Tumor Cell

Integrins can directly mediate metastatic tumor cell adhesion within the liver sinusoids

2004 ◽  
Vol 8 (8) ◽  
pp. 1049-1060 ◽  
Author(s):  
A ENNS ◽  
P GASSMANN ◽  
K SCHLUTER ◽  
T KORB ◽  
H SPIEGEL ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Tumor Cell ◽  
Metastatic Tumor ◽  
Tumor Cell Adhesion ◽  
Metastatic Tumor Cell ◽  
Liver Sinusoids

scholarly journals Organ-Specific Metastatic Tumor Cell Adhesion and Extravasation of Colon Carcinoma Cells with Different Metastatic Potential

2006 ◽  
Vol 169 (3) ◽  
pp. 1064-1073 ◽  
Author(s):  
Kerstin Schlüter ◽  
Peter Gassmann ◽  
Andreas Enns ◽  
Timo Korb ◽  
Andre Hemping-Bovenkerk ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Tumor Cell ◽  
Colon Carcinoma ◽  
Metastatic Tumor ◽  
Metastatic Potential ◽  
Carcinoma Cells ◽  
Tumor Cell Adhesion ◽  
Metastatic Tumor Cell ◽  
Colon Carcinoma Cells ◽  
Organ Specific

Connexin-43 facilitate metastatic tumor cell adhesion to lung vasculature

2008 ◽  
Vol 14 (S2) ◽  
pp. 1512-1513
Author(s):  
MK ElZarrad ◽  
AB Al-Mehdi
Keyword(s):  
Cell Adhesion ◽  
New Mexico ◽  
Tumor Cell ◽  
Connexin 43 ◽  
Metastatic Tumor ◽  
Tumor Cell Adhesion ◽  
Metastatic Tumor Cell

Extended abstract of a paper presented at Microscopy and Microanalysis 2008 in Albuquerque, New Mexico, USA, August 3 – August 7, 2008

scholarly journals Stromal fibroblasts induce metastatic tumor cell clusters via epithelial–mesenchymal plasticity

2019 ◽  
Vol 2 (4) ◽  
pp. e201900425 ◽  
Author(s):  
Yuko Matsumura ◽  
Yasuhiko Ito ◽  
Yoshihiro Mezawa ◽  
Kaidiliayi Sulidan ◽  
Yataro Daigo ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Tumor Cell ◽  
Transforming Growth Factor ◽  
Cluster Formation ◽  
Metastatic Tumor ◽  
M Cells ◽  
Stromal Fibroblasts ◽  
Cell Clusters ◽  
Metastatic Tumor Cell ◽  
E Cadherin

Emerging evidence supports the hypothesis that multicellular tumor clusters invade and seed metastasis. However, whether tumor-associated stroma induces epithelial–mesenchymal plasticity in tumor cell clusters, to promote invasion and metastasis, remains unknown. We demonstrate herein that carcinoma-associated fibroblasts (CAFs) frequently present in tumor stroma drive the formation of tumor cell clusters composed of two distinct cancer cell populations, one in a highly epithelial (E-cadherinhiZEB1lo/neg: Ehi) state and another in a hybrid epithelial/mesenchymal (E-cadherinloZEB1hi: E/M) state. The Ehi cells highly express oncogenic cell–cell adhesion molecules, such as carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) and CEACAM6 that associate with E-cadherin, resulting in increased tumor cell cluster formation and metastatic seeding. The E/M cells also retain associations with Ehi cells, which follow the E/M cells leading to collective invasion. CAF-produced stromal cell-derived factor 1 and transforming growth factor-β confer the Ehi and E/M states as well as invasive and metastatic traits via Src activation in apposed human breast tumor cells. Taken together, these findings indicate that invasive and metastatic tumor cell clusters are induced by CAFs via epithelial–mesenchymal plasticity.

scholarly journals A Defect in Cell-to-cell Adhesion via Integrin-Fibronectin Interactions in a Highly Metastatic Tumor Cell Line

1997 ◽  
Vol 88 (1) ◽  
pp. 64-71 ◽  
Author(s):  
Yoshiko Abe ◽  
Tateki Tsutsui ◽  
Jie Mu ◽  
Atsushi Kosugi ◽  
Hideo Yagita ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Tumor Cell ◽  
Cell Line ◽  
Tumor Cell Line ◽  
Metastatic Tumor ◽  
Metastatic Tumor Cell ◽  
Cell To Cell Adhesion

Interleukin-1 increases tumor cell adhesion to endothelial cells through an RGD dependent mechanism: in vitro and in vivo studies

1990 ◽  
Vol 8 (1) ◽  
pp. 27-32 ◽  
Author(s):  
Davide Lauri ◽  
Maria-Cruz Bertomeu ◽  
F. William Orr ◽  
Eva Bastida ◽  
D. Sauder ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cell Adhesion ◽  
Tumor Cell ◽  
Interleukin 1 ◽  
In Vivo Studies ◽  
Tumor Cell Adhesion ◽  
Dependent Mechanism

scholarly journals Real-time PET analysis of metastatic tumor cell trafficking in vivo and its relation to adhesion properties

1995 ◽  
Vol 1238 (2) ◽  
pp. 99-106 ◽  
Author(s):  
Chieko Koike ◽  
Naoto Oku ◽  
Manabu Watanabe ◽  
Hideo Tsukada ◽  
Takeharu Kakiuchi ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Real Time ◽  
Metastatic Tumor ◽  
Cell Trafficking ◽  
Adhesion Properties ◽  
Metastatic Tumor Cell
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