Integrity of actin fibers and microtubules influences metastatic tumor cell adhesion

2004 ◽  
Vol 299 (1) ◽  
pp. 236-247 ◽  
Author(s):  
Timo Korb ◽  
Kerstin Schlüter ◽  
Andreas Enns ◽  
Hans-Ulrich Spiegel ◽  
Norbert Senninger ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Tumor Cell ◽  
Metastatic Tumor ◽  
Tumor Cell Adhesion ◽  
Metastatic Tumor Cell

Integrins can directly mediate metastatic tumor cell adhesion within the liver sinusoids

2004 ◽  
Vol 8 (8) ◽  
pp. 1049-1060 ◽  
Author(s):  
A ENNS ◽  
P GASSMANN ◽  
K SCHLUTER ◽  
T KORB ◽  
H SPIEGEL ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Tumor Cell ◽  
Metastatic Tumor ◽  
Tumor Cell Adhesion ◽  
Metastatic Tumor Cell ◽  
Liver Sinusoids

scholarly journals Organ-Specific Metastatic Tumor Cell Adhesion and Extravasation of Colon Carcinoma Cells with Different Metastatic Potential

2006 ◽  
Vol 169 (3) ◽  
pp. 1064-1073 ◽  
Author(s):  
Kerstin Schlüter ◽  
Peter Gassmann ◽  
Andreas Enns ◽  
Timo Korb ◽  
Andre Hemping-Bovenkerk ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Tumor Cell ◽  
Colon Carcinoma ◽  
Metastatic Tumor ◽  
Metastatic Potential ◽  
Carcinoma Cells ◽  
Tumor Cell Adhesion ◽  
Metastatic Tumor Cell ◽  
Colon Carcinoma Cells ◽  
Organ Specific

Connexin-43 facilitate metastatic tumor cell adhesion to lung vasculature

2008 ◽  
Vol 14 (S2) ◽  
pp. 1512-1513
Author(s):  
MK ElZarrad ◽  
AB Al-Mehdi
Keyword(s):  
Cell Adhesion ◽  
New Mexico ◽  
Tumor Cell ◽  
Connexin 43 ◽  
Metastatic Tumor ◽  
Tumor Cell Adhesion ◽  
Metastatic Tumor Cell

Extended abstract of a paper presented at Microscopy and Microanalysis 2008 in Albuquerque, New Mexico, USA, August 3 – August 7, 2008

scholarly journals Stromal fibroblasts induce metastatic tumor cell clusters via epithelial–mesenchymal plasticity

2019 ◽  
Vol 2 (4) ◽  
pp. e201900425 ◽  
Author(s):  
Yuko Matsumura ◽  
Yasuhiko Ito ◽  
Yoshihiro Mezawa ◽  
Kaidiliayi Sulidan ◽  
Yataro Daigo ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Tumor Cell ◽  
Transforming Growth Factor ◽  
Cluster Formation ◽  
Metastatic Tumor ◽  
M Cells ◽  
Stromal Fibroblasts ◽  
Cell Clusters ◽  
Metastatic Tumor Cell ◽  
E Cadherin

Emerging evidence supports the hypothesis that multicellular tumor clusters invade and seed metastasis. However, whether tumor-associated stroma induces epithelial–mesenchymal plasticity in tumor cell clusters, to promote invasion and metastasis, remains unknown. We demonstrate herein that carcinoma-associated fibroblasts (CAFs) frequently present in tumor stroma drive the formation of tumor cell clusters composed of two distinct cancer cell populations, one in a highly epithelial (E-cadherinhiZEB1lo/neg: Ehi) state and another in a hybrid epithelial/mesenchymal (E-cadherinloZEB1hi: E/M) state. The Ehi cells highly express oncogenic cell–cell adhesion molecules, such as carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) and CEACAM6 that associate with E-cadherin, resulting in increased tumor cell cluster formation and metastatic seeding. The E/M cells also retain associations with Ehi cells, which follow the E/M cells leading to collective invasion. CAF-produced stromal cell-derived factor 1 and transforming growth factor-β confer the Ehi and E/M states as well as invasive and metastatic traits via Src activation in apposed human breast tumor cells. Taken together, these findings indicate that invasive and metastatic tumor cell clusters are induced by CAFs via epithelial–mesenchymal plasticity.

scholarly journals A Defect in Cell-to-cell Adhesion via Integrin-Fibronectin Interactions in a Highly Metastatic Tumor Cell Line

1997 ◽  
Vol 88 (1) ◽  
pp. 64-71 ◽  
Author(s):  
Yoshiko Abe ◽  
Tateki Tsutsui ◽  
Jie Mu ◽  
Atsushi Kosugi ◽  
Hideo Yagita ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Tumor Cell ◽  
Cell Line ◽  
Tumor Cell Line ◽  
Metastatic Tumor ◽  
Metastatic Tumor Cell ◽  
Cell To Cell Adhesion

Platelet and Shear Rate Promote Tumor Cell Adhesion to Human Endothelial Extracellular Matrix - Absence of a Role for Platelet Cyclooxygenase

1989 ◽  
Vol 61 (03) ◽  
pp. 485-489 ◽  
Author(s):  
Eva Bastida ◽  
Lourdes Almirall ◽  
Antonio Ordinas
Keyword(s):  
Cell Adhesion ◽  
Shear Rate ◽  
Tumor Cell ◽  
Umbilical Vein ◽  
Blood Platelets ◽  
Flow Conditions ◽  
Tumor Cell Adhesion ◽  
Rate Dependent ◽  
Static Conditions

SummaryBlood platelets are thought to be involved in certain aspects of malignant dissemination. To study the role of platelets in tumor cell adherence to vascular endothelium we performed studies under static and flow conditions, measuring tumor cell adhesion in the absence or presence of platelets. We used highly metastatic human adenocarcinoma cells of the lung, cultured human umbilical vein endothelial cells (ECs) and extracellular matrices (ECM) prepared from confluent EC monolayers. Our results indicated that under static conditions platelets do not significantly increase tumor cell adhesion to either intact ECs or to exposed ECM. Conversely, the studies performed under flow conditions using the flat chamber perfusion system indicated that the presence of 2 × 105 pl/μl in the perfusate significantly increased the number of tumor cells adhered to ECM, and that this effect was shear rate dependent. The maximal values of tumor cell adhesion were obtained, in presence of platelets, at a shear rate of 1,300 sec-1. Furthermore, our results with ASA-treated platelets suggest that the role of platelets in enhancing tumor cell adhesion to ECM is independent of the activation of the platelet cyclooxygenase pathway.

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