Plant Products with Antifungal Activity: From Field to Biotechnology Strategies

2018 ◽  
pp. 35-71
Author(s):  
Giovanna Simonetti ◽  
Alessio Valletta ◽  
Olga Kolesova ◽  
Gabriella Pasqua
Keyword(s):  
Antifungal Activity ◽  
Plant Products

Antifungal Activity of Plant Products for the Management of Fruit Rot Infection in Chillies

2014 ◽  
Vol 13 (2) ◽  
pp. 87-99
Author(s):  
S. Sundaramoo ◽  
S. Usharani ◽  
Ancy P. George
Keyword(s):  
Antifungal Activity ◽  
Fruit Rot ◽  
Plant Products

scholarly journals Talinum paniculatum: a plant with antifungal potential mitigates fluconazole-induced oxidative damage-mediated growth inhibition of Candida albicans

2020 ◽  
Vol 49 (2) ◽  
Author(s):  
Cláudio Daniel Cerdeira ◽  
Jeferson J. Da Silva ◽  
Manoel F. R. Netto ◽  
Marcelo F. G. Boriollo ◽  
Gabriel O. I. Moraes ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Antifungal Activity ◽  
Growth Inhibition ◽  
Reference Strain ◽  
Radical Scavenging ◽  
Clinical Isolates ◽  
Antioxidant Compounds ◽  
Plant Products ◽  
Crude Leaf Extract ◽  
Antifungal Potential

Aims: This study investigated the bioactivity of the crude leaf extract (CLE) and fractions hexane (HX) and ethyl acetate (EtOAc) from Talinum paniculatum alone and in association with fluconazole (FLC) against reference strain and clinical isolates of FLC-resistant Candida albicans. Furthermore, the antioxidant capability, chemical composition of this plant, and the effect’s underlying mechanisms were evaluated. Methods: The antifungal activity was evaluated using checkerboard assay to establish the minimum inhibitory (MIC) and minimum microbicidal concentrations (MMC). During FLC and plant products challenges, the reactive oxygen species (ROS) generation (hydroxyl radicals [HO•]) were detected in C. albicans cells using the membrane-permeable fluorescent probes APF and HPF. High-performance liquid chromatography (HPLC) profile, quantitative analysis of antioxidant compounds, and free radical scavenging activity (DPPH assay) tests were performed. Results: The CLE and fractions presented outstanding antifungal activity and selectivity against C. albicans cells but had no synergistic effects with FLC. The MIC values for CLE and its fractions against C. albicans reference strain were in the order of HX (31.25 μg ml–1) < EtOAc (62.5 μg ml–1) < CLE (500 μg ml–1), and against FLC-resistant C. albicans HX (125 μg ml–1) = EtOAc < CLE (500 μg ml–1). CLE and its fractions had more potent antifungal activities than FLC against the clinical isolates. Moreover, fungicidal effects for these plant products were demonstrated against FLC-resistant C. albicans, which further confirmed an antifungal potential. Conversely, during association, plant products were shown to cause an increase in FLC MIC anywhere from 2- to 16-fold. FLC exposure led to an increase in the steady-state levels of ROS (HO•) in C. albicans cells. Next, we found that the increases in FLC MICs were owing to action of antioxidants containing-CLE and its fractions in preventing FLC-induced ROS-mediated growth inhibition of C. albicans. Conclusion: T. paniculatum can be a source of bioactive compounds with antifungal potential. However, because of the common use of its edible leaf, caution is advised during therapy with FLC (since it can decrease FLC susceptibility). 

Antifungal activity of a flavonoid-rich fraction from Costus spicatus leaves against dermatophytes

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
DN Silva ◽  
MJ Gonçalves ◽  
MT Amaral ◽  
MT Batista
Keyword(s):  
Antifungal Activity

Antifungal Activity of Brassica rapa-Derived Extracts Against F. oxysporum

Planta Medica ◽  
2013 ◽  
Vol 79 (10) ◽  
Author(s):  
JE Fierro ◽  
P Jiménez ◽  
ED Coy-Barrera
Keyword(s):  
Antifungal Activity ◽  
Brassica Rapa

Improved isolation of α-mangostin from the fruit hull of Garcinia mangostana and its antioxidant and antifungal activity

Planta Medica ◽  
2006 ◽  
Vol 72 (11) ◽  
Author(s):  
J Puripattanavong ◽  
W Khajorndetkun ◽  
W Chansathirapanich
Keyword(s):  
Antifungal Activity ◽  
Garcinia Mangostana

Therapeutic efficacy of some extracts of hot pepper fruits (Capsicum annuum) and Sumac seeds (Rhus coriaria) on the growth of some isolated dermatophytes species

2018 ◽  
Vol 1 (3) ◽  
pp. 52-62
Author(s):  
Sara Omran ◽  
Abdulghani Alsamarai ◽  
Firas Razzzaq
Keyword(s):  
Antifungal Activity ◽  
Fungal Infection ◽  
Aqueous Extract ◽  
Plant Extracts ◽  
Therapeutic Efficacy ◽  
Diffusion Method ◽  
Quantitative Detection ◽  
Hot Pepper ◽  
Alcoholic Extract ◽  
Dermatology Clinic

Background: Fungal infections are one of the common skin diseases with difficulty in their treatment approach. The present efficient drugs for fungal infection are limited. Aim: To determine the therapeutic efficacy of plant extracts as alternative antifungal agents. Materials and methods: 100 clinical samples [68 from female and 32 from male] were collected during the period from March to July 2017 from subjects attending Dermatology Clinic in Salah Uldean General Hospital. Fungal infection was diagnosed with using KOH wet preparation. Fungal species identified by using conventional approach. The active ingredients existing in the plant extracts were detected and analyzed through qualitative and quantitative detection technique of chemical compounds using a high performance liquid chromatographic device (HPLC). Agar diffusion method was used to determine antifungal activity of plant extracts. Results: Direct microscopic examination showed that there were (75%) positive samples, while culture shows (67%) positive samples. The isolated dermatophytes belong to Epidermophyoton, Microsporum, and Trichophyton genus. The predominant dermatophytes were T. rubrum (25%) species. The highest frequency of infection was in the age group of 11-20 years. The sensitivity of the tested fungi to the aqueous and alcoholic plant extracts varies. Alcoholic extract of the hot pepper plant was more effective as antifungal than the aqueous extract of the same plant. However, aqueous hot pepper extracts was more effective against T. mentagrophyte than that of alcoholic extract. Additionally, alcoholic Sumac extract shows higher efficacy that aqueous extract. Conclusion: Hot pepper and Sumac extracts show antifungal activity against Microsporum canis, Trichophyton rubrum and T. mentagrophyte.

In vitro Antifungal Activity of a 29-kDa Glycoprotein Purified from the Galls of Quercus infectoria

2005 ◽  
Vol 40 (1-2) ◽  
pp. 43-54 ◽  
Author(s):  
K. Yamunarani ◽  
R. Jaganathan ◽  
R. Bhaskaran ◽  
P. Govindaraju ◽  
R. Velazhahan
Keyword(s):  
Antifungal Activity ◽  
Quercus Infectoria ◽  
In Vitro Antifungal Activity
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