Endophytic Fungi: Promising Source of Novel Bioactive Compounds

2019 ◽  
pp. 243-265 ◽  
Author(s):  
Fazilath Uzma ◽  
Chakrabhavi D. Mohan ◽  
Chandra N. Siddaiah ◽  
Srinivas Chowdappa
Keyword(s):  
Bioactive Compounds ◽  
Endophytic Fungi ◽  
Promising Source

scholarly journals Antimicrobial activities of secondary metabolites of endophytic fungi isolated from Catharanthus roseus

2017 ◽  
Vol 7 (1) ◽  
pp. 15-22 ◽  
Author(s):  
Mark O. Akpotu ◽  
Peter M. Eze ◽  
Chika C. Abba ◽  
Blessing O. Umeokoli ◽  
Charles U. Nwachukwu ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Bioactive Compounds ◽  
Endophytic Fungi ◽  
Catharanthus Roseus ◽  
High Performance ◽  
Antimicrobial Activities ◽  
Antibacterial And Antifungal Activities ◽  
Rice Medium ◽  
Antibacterial And Antifungal ◽  
Promising Source

Introduction: Recently, several endophytes have been shown to possess the potentials to synthesize novel bioactive compounds that have found use for drug discovery. We isolated endophytic fungi associated with Catharanthus roseus collected from the river banks of Amassoma in Southern Nigeria, and identified some of their bioactive secondary metabolites. Methods: The fungi were subjected to solid-state fermentation on rice medium and the metabolites were extracted using ethyl acetate. The fungal crude extracts were screened for antimicrobial activity and were also subjected to high-performance liquid chromatography-diode-array detection (HPLC-DAD) analysis for the identification of the bioactive compounds. Results: The fungal extracts showed both antibacterial and antifungal activities with minimum inhibitory concentrations ranging from 0.0625 to 1 mg/mL. The HPLC-DAD analysis of the extracts suggested the presence of citreoisocoumarin, citreoisocoumarinol, questinol, hydroxyemodin, acropyrone, methyl 2-(4-hydroxyphenyl) acetate, nigricinol, and cladosporin. Conclusion: The results of this study suggest that endophytic fungi associated with C. roseus could be a promising source of novel bioactive compounds with pharmaceutical and industrial importance.

Biological potential and chemical composition of bioactive compounds from endophytic fungi associated with thai mangrove plants

2021 ◽  
Vol 141 ◽  
pp. 66-76
Author(s):  
Kathawut Sopalun ◽  
Wanpen Laosripaiboon ◽  
Anyalak Wachirachaikarn ◽  
Siriluck Iamtham
Keyword(s):  
Chemical Composition ◽  
Bioactive Compounds ◽  
Endophytic Fungi ◽  
Mangrove Plants ◽  
Biological Potential

scholarly journals Antifungal activity of extracts from Atacama Desert fungi againstParacoccidioides brasiliensis and identification ofAspergillus felis as a promising source of natural bioactive compounds

2016 ◽  
Vol 111 (3) ◽  
pp. 209-217 ◽  
Author(s):  
Graziele Mendes ◽  
Vívian N Gonçalves ◽  
Elaine M Souza-Fagundes ◽  
Markus Kohlhoff ◽  
Carlos A Rosa ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Bioactive Compounds ◽  
Atacama Desert ◽  
Promising Source

scholarly journals Evaluation of antimicrobial, antioxidant and cytotoxic properties of bioactive compounds produced from endophytic fungi of Himalayan yew (Taxus wallichiana) in Nepal

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 379 ◽  
Author(s):  
Dhurva Prasad Gauchan ◽  
Pratistha Kandel ◽  
Astha Tuladhar ◽  
Ashesh Acharya ◽  
Upendra Kadel ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Secondary Metabolites ◽  
Ethyl Acetate ◽  
Bioactive Compounds ◽  
Endophytic Fungi ◽  
Diffusion Method ◽  
Dry Extract ◽  
Brine Shrimp Lethality Assay ◽  
Fungal Extracts ◽  
Taxus Wallichiana

Background: Endophytic fungi are largely underexplored in the discovery of natural bioactive products though being rich sources of novel compounds with promising pharmaceutical potential. In this study, Taxus wallichiana, which has huge medicinal value, was investigated for its endophytic diversity and capability to produce bioactive secondary metabolites by analyzing antioxidant, antimicrobial and cytotoxic properties. Methods: The endophytes were identified by ITS-PCR using genomic DNA samples. The secondary metabolites were extracted by solvent extraction method using ethyl acetate. The antioxidant activity was analyzed by Thin Layer Chromatography, Total Phenol Content (TPC), Total Flavonoid Content (TFC) and DPPH assay, and the antimicrobial activity was analyzed by agar-well diffusion method. Brine shrimp lethality assay was used to analyze the cytotoxicity of the fungal extracts. Results: Out of 16 different Taxus trees sampled from different locations of Dhorpatan, 13 distinctive endophytic fungi were isolated and grouped into 9 different genera: Bjerkandera, Trichoderma, Preussia, Botrytis, Arthrinium, Alternaria, Cladosporium, Sporormiella and Daldinia. The ethyl acetate extracts isolated from three endophytic fungi: Alternaria alternata, Cladosporium cladosporioides and Alternaria brassicae showed significant TPC values of 204±6.144, 312.3±2.147 and 152.7±4.958µg GAE/mg of dry extract, respectively, and TFC values of 177.9±2.911, 644.1±4.202 and 96.38±3.851µg RE/mg of dry extract, respectively. Furthermore, these three extracts showed a dose dependent radical scavenging activity with IC50 concentration of 22.85, 22.15 and 23.001 µg/ml, respectively. The extracts of C. cladosporioides and A. brassicae also showed promising antimicrobial activity against Escherichia coli, Staphylococcus aureus and Bacillus subtilis with a minimum inhibitory concentration of 250μg/ml for all bacteria. Both the samples showed cytotoxic property against shrimp nauplii with LC50 of 104.2 and 125.9µg/ml, respectively. Conclusions: The crude fungal extracts obtained from endophytes: A. alternata, C. cladosporioides and A. brassicae upon purification and further identification of the bioactive compounds can be a fascinating source for novel pharmaceutical agents.

Bioprospecting of Endophytic Fungi for Bioactive Compounds

2018 ◽  
pp. 651-697
Author(s):  
C. Ganesh Kumar ◽  
Poornima Mongolla
Keyword(s):  
Bioactive Compounds ◽  
Endophytic Fungi

Endophytic Fungi for a Sustainable Production of Major Plant Bioactive Compounds

2020 ◽  
pp. 195-207
Author(s):  
Jisha Satheesan ◽  
Kallevettankuzhy Krishnannair Sabu
Keyword(s):  
Bioactive Compounds ◽  
Endophytic Fungi ◽  
Sustainable Production

Endolichenic Fungi: A Promising Source for Novel Bioactive Compounds

2019 ◽  
pp. 69-118
Author(s):  
Manish Tripathi ◽  
Yogesh Joshi
Keyword(s):  
Bioactive Compounds ◽  
Endolichenic Fungi ◽  
Promising Source

Insights into the bioactive compounds of endophytic fungi in mangroves

2020 ◽  
pp. 277-292
Author(s):  
Tuan Noraida Tuan Hamzah ◽  
Munir Ozturk ◽  
Volkan Altay ◽  
Khalid Rehman Hakeem
Keyword(s):  
Bioactive Compounds ◽  
Endophytic Fungi

Endophytic Fungi: A Quintessential Source of Potential Bioactive Compounds

2019 ◽  
pp. 277-309
Author(s):  
Vineet Meshram ◽  
Mahiti Gupta
Keyword(s):  
Bioactive Compounds ◽  
Endophytic Fungi
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