This chapter on interventional-related spine anatomy provides a concise overview of normal spinal anatomy, as well as commonly encountered pathologic conditions, with a particular emphasis on the relevant imaging findings. The introduction outlines potential sources of back pain and their presenting symptomatology. The chapter reviews the main imaging modalities used to evaluate the spine and discusses their specific advantages and disadvantages. The anatomy of the muscles of the vertebral column, the vertebral column itself, and common variations), intervertebral ligaments and discs, vertebral joints, meninges and spinal cord, spinal nerves, and vasculature of the spinal column and spinal cord are reviewed. The discussion includes multiple radiographic, computed tomography (CT), magnetic resonance imaging (MRI), and angiographic images, as well as illustrations to supplement the text.