Do Menopausal Symptoms Account for the Declines in Cognitive Function During the Menopausal Transition?

Author(s):  
Pauline M. Maki ◽  
Miriam T. Weber
2018 ◽  
Author(s):  
Susan D. Reed ◽  
Eliza L. Sutton

The female reproductive system matures in a continuous, natural process from menarche to menopause as the finite numbers of oocytes produced during fetal development are gradually lost to ovulation and senescence. Menopause is defined as the permanent cessation of menses; by convention, the diagnosis of menopause is not made until the individual has had 12 months of amenorrhea. Menopause is thus characterized by the menstrual changes that reflect oocyte depletion and subsequent changes in ovarian hormone production. However, hormonal changes, rather than the cessation of menstruation itself, cause the manifestations that occur around the time of menopause. Therefore, a woman who has undergone a hysterectomy but who retains her ovaries can experience normal menopausal symptoms as oocyte depletion leads to changes in estrogen levels, even though cessation of menstruation occurred with surgery. This review covers definitions, natural menopause, menopausal transition and postmenopausal symptom management, and premature ovarian insufficiency. Figures show stages of reproductive aging, serum concentrations of hormones during menopausal transition and postmenopause, hormonal changes associated with reproductive aging, symptoms of menopausal transition and menopause, treatment algorithm(s), and Women’s Health Initiative findings: risks and benefits of estrogen alone and estrogen plus progestin by age group: 50 to 59, 60 to 69, and 70 to 79 years. Tables list target tissues, physical manifestations, and menopausal symptoms; selective estrogen receptor modulators used in postmenopausal women; differential diagnosis and evaluation of common menopausal symptoms; estrogen doses; progestogen dosing for endometrial protection; nonhormonal pharmaceutical hot flash therapies; and pharmacologic therapy for genitourinary atrophy. This review contains 6 highly rendered figures, 7 tables, and 119 references.


2020 ◽  
Author(s):  
Susan D. Reed ◽  
Eliza L. Sutton

The female reproductive system matures in a continuous, natural process from menarche to menopause as the finite numbers of oocytes produced during fetal development are gradually lost to ovulation and senescence. Menopause is defined as the permanent cessation of menses; by convention, the diagnosis of menopause is not made until the individual has had 12 months of amenorrhea. Menopause is thus characterized by the menstrual changes that reflect oocyte depletion and subsequent changes in ovarian hormone production. However, hormonal changes, rather than the cessation of menstruation itself, cause the manifestations that occur around the time of menopause. Therefore, a woman who has undergone a hysterectomy but who retains her ovaries can experience normal menopausal symptoms as oocyte depletion leads to changes in estrogen levels, even though cessation of menstruation occurred with surgery. This review covers definitions, natural menopause, menopausal transition and postmenopausal symptom management, and premature ovarian insufficiency. Figures show stages of reproductive aging, serum concentrations of hormones during menopausal transition and postmenopause, hormonal changes associated with reproductive aging, symptoms of menopausal transition and menopause, treatment algorithm(s), and Women’s Health Initiative findings: risks and benefits of estrogen alone and estrogen plus progestin by age group: 50 to 59, 60 to 69, and 70 to 79 years. Tables list target tissues, physical manifestations, and menopausal symptoms; selective estrogen receptor modulators used in postmenopausal women; differential diagnosis and evaluation of common menopausal symptoms; estrogen doses; progestogen dosing for endometrial protection; nonhormonal pharmaceutical hot flash therapies; and pharmacologic therapy for genitourinary atrophy. This review contains 6 figures, 8 tables, and 122 references.


2016 ◽  
Vol 129 (7) ◽  
pp. 771-777 ◽  
Author(s):  
Jian-Ping Zhang ◽  
Yao-Qin Wang ◽  
Mei-Qin Yan ◽  
Zhao-Ai Li ◽  
Xiu-Ping Du ◽  
...  

2007 ◽  
Vol 7 (sup1) ◽  
pp. S157-S180 ◽  
Author(s):  
Jeanne Leventhal Alexander ◽  
Barbara R Sommer ◽  
Lorraine Dennerstein ◽  
Miglena Grigorova ◽  
Thomas Neylan ◽  
...  

2017 ◽  
Vol 31 (1) ◽  
pp. 10-15 ◽  
Author(s):  
Saria Tasnim ◽  
Md Abidul Haque ◽  
Summyia Nazmeen

Objective (s): The objective was to explore frequency of menopause related symptoms among middle aged women and their perception about menopause,Materials and Methods: This was a cross sectional study carried during March to May 2013 among women aged 45-60 years at the out patient Department of Obstetrics and Gynaecology of a tertiary hospital using structured questionnaire. Information was sought regarding menstrual pattern, self reported menopausal symptoms and attitude towards menopausal transition. Data analysis was done using SPSS version 16.Results: Total 106 women were interviewed, The mean age of the respondents was 50.3± 53 years, and 58.5% were post menopausal and 41.5% in menopausal transition. More than half (59.4%) were illiterate, 32% were working. Common menopausal symptoms were insomnia 51.8%, body ache 44.3% and feeling sad 31.3%. Hot flush and night sweats were reported by 50% and 33% respectively. Half of them regard menopause as normal and health seeking for menopausal problems was 42.5%.Conclusion: A significant proportion of women were suffering from vasomotor and psychosomatic symptoms but most of them did not seek treatment. To ensure quality of life health needs of middle aged women should be identified and their views towards menopause incorporated in formulating services for themBangladesh J Obstet Gynaecol, 2016; Vol. 31(1) : 10-15


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