Liver Ultrasonography

2020 ◽  
pp. 459-471
Author(s):  
Laura Iliescu
2021 ◽  
Vol 10 (4) ◽  
pp. 669
Author(s):  
Mélanie Maltais ◽  
Diane Brisson ◽  
Daniel Gaudet

Non-alcoholic fatty liver disease (NAFLD) is frequent in patients with features of the metabolic syndrome (MetS), obesity, or type 2 diabetes. Lipoprotein lipase (LPL) is the main driver of triglyceride (TG) hydrolysis in chylomicrons and very-low density lipoproteins (VLDL). In some patients with MetS, dysfunction of this pathway can lead to plasma TG values > 10 mmol/L (multifactorial chylomicronemia or MCS). Chylomicronemia also characterizes LPL deficiency (LPLD), a rare autosomal recessive disease called familial chylomicronemia syndrome (FCS), which is associated with an increased risk of recurrent pancreatitis. This study aims to investigate the expression of NAFLD, as assessed by transient elastography, in MCS and FCS subjects. Data were obtained from 38 subjects with chylomicronemia; 19 genetically confirmed FCS and 19 sex- and age-matched MCS. All participants underwent liver ultrasonography and stiffness measurement after a 4-h fast using transient elastography (FibroScan®, Echosens, Waltham, MA, USA). NAFLD (controlled attenuation parameter (CAP) > 280 dB/m) was observed in 42.1% of FCS and 73.7% of MCS subjects (p = 0.05). FCS subjects had lower body mass index (BMI) than MCS. Only 25% of FCS subjects with NAFLD had a BMI ≥ 30 compared to 64.3% in MCS (p = 0.004). In FCS, NAFLD occurred even in the presence of very low (≤18 kg/m2) BMI. In both FCS and MCS, CAP was negatively associated with acute pancreatitis risk. In this study, NAFLD was commonly observed in both FCS and MCS subjects and occurred independently of the BMI and fasting glucose values in FCS; NAFLD was associated with a lower occurrence of acute pancreatitis episodes.


Author(s):  
Randhir Singh ◽  
S. N.S. Randhawa ◽  
C. S. Randhawa ◽  
Sushma Chhabra ◽  
Naimi Chand

Background: Use of novel biomarkers is the need of hour for prediction and early diagnosis of bovine production diseases such as hepatic lipidosis (HL). Liver ultrasonography and estimation of liver specific enzymes activities have been successfully used for diagnosis of HL. However, use of inflammatory mediator like tumor necrosis factor-á (TNF–á) or acute phase proteins (APPs) like C reactive protein (CRP), serum amyloid A (SAA) and haptoglobin (Hp) as biomarkers of HL has not been elucidated. The present study was therefore designed to evaluate liver ultrasonography and serum APPs concentrations as early predictive biomarkers of bovine HL. Methods: This study included one hundred one (101) multiparous crossbred cows in advanced pregnancy from dairy farm in Punjab, India. The cows were grouped according to their transition stage i.e., Far off dry (FOD), close up dry (CUD) and Fresh (F). Liver ultrasonography along with hemato-biochemical analysis and estimation of acute phase proteins was carried out during different stages of transition period. Result: This study included 101 cows, of which 71 (70.3%) had ultrasonographic features of normal liver and 30 (29.7%) had ultrasonographic features of HL (Grade I, 10 cows; Grade II, 12 cows; Grade III, 8 cows). Cows with HL had significantly lower levels of hemoglobin (Hb), packed cell volume (PCV), total erythrocyte count (TEC), total plasma protein (TPP), glucose, total calcium (Ca) and zinc (Zn) and significantly higher levels of plasma urea nitrogen (PUN), non-esterified fatty acid (NEFA), beta hydroxyl butyric acid (BHBA), alkaline phosphatase (ALP), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), glutamate dehydrogenase (GDH), lactate dehydrogenase (LDH), TNF–á, CRP, SAA and Hp compared to the negative controls. The APPs, liver ultrasonography, liver enzymes along with NEFA and BHBA could be used as biomarkers for prediction and early diagnosis of HL in cows.


2003 ◽  
Vol 2003.7 (0) ◽  
pp. 15-16
Author(s):  
Takanori KONNO ◽  
Yasukazu NISHI ◽  
Kazuyoshi HOSHINO ◽  
Toshikatsu OTANI ◽  
Risa TOUNE ◽  
...  

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 6065-6065
Author(s):  
F. Puglisi ◽  
A. Follador ◽  
A. M. Minisini ◽  
G. G. Cardellino ◽  
S. Russo ◽  
...  

Author(s):  
Semra Icer ◽  
Turkan Ikizceli ◽  
Abdulhakim Coskun ◽  
Musa Hakan Asyali

1995 ◽  
Vol 25 (3) ◽  
pp. 128-130 ◽  
Author(s):  
Mohamed El-Shazly ◽  
D O Okello ◽  
M G Kawooya

A study of 41 clinically diagnosed cases of possible tropical splenomegaly syndrome (TSS) was undertaken in Mulago Hospital, Kampala, Uganda, to determine the appropriateness of liver ultrasonography in confirming a diagnosis of TSS. Definitive diagnosis of TSS was made on liver biopsy in 35 (85%) cases. Abdominal ultrasound showed that 30 of the confirmed cases of TSS had normal liver echo-texture and portal vein diameter, and five had abnormally increased liver echo-texture. The combination of massive splenomegaly and hepatomegaly, together with normal ultrasound features of the liver was highly suggestive of TSS. The sensitivity of this criterion was 86% and the specificity was 83%. This non-invasive approach to the diagnosis of TSS is associated with less hazards than liver biopsy, and a normal echogram could be used to make the diagnosis in over 80% of cases, in the field where histopathology may be lacking.


Author(s):  
Huu Thien Ho

TÓM TẮT Bệnh nhi 6 tháng tuổi được chẩn đoán u nguyên bào gan, ban đầu được xem là không thể cắt bỏ được vì khối u có kích thước lớn và lan tỏa. Bệnh nhân được điều trị 4 đợt hóa chất cisplatin với thời gian cách nhau 2 tuần. Kết quả chụp cắt lớp vi tính sau 4 đợt hóa trị cho thấy khối u đã thu nhỏ lại và có thể cắt bỏ. Khối u đã được cắt bỏ bằng phương pháp phẫu thuật cắt gan trung tâm. Bệnh nhân đã có thể ăn uống trở lại vào ngày thứ tư và xuất viện vào ngày thứ bảy sau mổ. Bác sĩ chuyên khoa nhi ung bướu đã theo dõi bệnh nhân bằng siêu âm gan, alpha - fetoprotein và tiếp tục điềutrị thêm 2 chu kỳ cisplatin. ABSTRACT CENTRAL HEPATECTOMY IN A 6 - MONTH - OLD CHILD WITH HEPATOBLASTOMA FOLLOWING CHEMOTHERAPY A hepatoblastoma in a 6 - month - old child was initially considered unresectable because of diffuse liver involvement. The patient received 4 courses of cisplatin with an interval time of 2 weeks. A computed tomography scan after 4 courses of chemotherapy showed shrinking of the tumor, which made it resectable, and the tumor was removed by central hepatectomy. The patient was able to eat a regular diet on the fourth day and was sent discharge on the seventh day, after the operation. The pediatric oncologist followed the patient with liver ultrasonography and alpha - fetoprotein and administered 2 more cycles of cisplatin. Keywords: Central Hepatectomy, Hepatoblastoma, children.


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