270 Degrees Fundoplication for Gastroesophageal Reflux Esophagitis

2021 ◽  
pp. 19-28
Author(s):  
Ivo A. M. J. Broeders
Keyword(s):  
Gastroesophageal Reflux ◽  
Reflux Esophagitis

Effect of erythromycin on postprandial gastroesophageal reflux in reflux esophagitis

1997 ◽  
Vol 10 (1) ◽  
pp. 34-37 ◽  
Author(s):  
C. Pehl ◽  
A. Pfeiffer ◽  
B. Wendl ◽  
B. Stellwag ◽  
H. Kaess
Keyword(s):  
Gastroesophageal Reflux ◽  
Reflux Esophagitis

scholarly journals VERTICAL GASTRECTOMY VS. EXTENDED VERTICAL GASTRECTOMY: WHAT IS THE IMPACT ON GASTROESOPHAGEAL REFLUX DISEASE IN OBESE RATS?

2020 ◽  
Vol 33 (2) ◽  
Author(s):  
José Aparecido VALADÃO ◽  
Plinio da Cunha LEAL ◽  
Eduardo José Silva Gomes de OLIVEIRA ◽  
Orlando Jorge Martins TORRES ◽  
Luis Eduardo Veras PINTO ◽  
...  
Keyword(s):  
Weight Loss ◽  
Gastroesophageal Reflux ◽  
Reflux Esophagitis ◽  
Cafeteria Diet ◽  
Super Obesity ◽  
Vertical Gastrectomy ◽  
Post Operative Period ◽  
Significant Difference ◽  
Obese Rats ◽  
The Impact

ABSTRACT Background: Extended vertical gastrectomy is a variation of the vertical gastrectomy technique requiring studies to elucidate safety in relation to gastroesophageal reflux. Aim: To analyze comparatively vertical gastrectomy (VG) and extended vertical gastrectomy (EVG) in rats with obesity induced by cafeteria diet in relation to the presence of reflux esophagitis, weight loss and macroscopic changes related to the procedures. Methods: Thirty Wistar rats were randomized into three groups, and after the obesity induction period by means of a 28-day cafeteria diet, underwent a simulated surgery (CG), VG and VGA. The animals were followed up for 28 days in the post-operative period, and after euthanasia, the reflux esophagitis evaluation was histopathologically performed. Weight and macroscopy were the other variables; weight was measured weekly and the macroscopic evaluation was performed during euthanasia. Results: All animals presented some degree of inflammation and the presence of at least one inflammation criterion; however, there was no statistically significant difference in the analysis among the groups. In relation to weight loss, the animals in CG showed a gradual increase during the whole experiment, evolving to super-obesity at the end of the study, while the ones with VG and EVG had weight regain after the first post-operative period; however, a less marked regain compared to CG, both for VG and EVG. Conclusion: There is no difference in relation to reflux esophagitis VG and EVG, as well as macroscopic alterations, and both techniques have the ability to control the evolution of weight during postoperative period in relation to CG.

scholarly journals CD8 T-Cell–Predominant Lymphocytic Esophagitis is One of the Major Patterns of Lymphocytic Inflammation in Gastroesophageal Reflux Disease

2020 ◽  
Author(s):  
Robin Moiseff ◽  
Nicholas Olson ◽  
Arief A. Suriawinata ◽  
Richard I. Rothstein ◽  
Mikhail Lisovsky
Keyword(s):  
T Cells ◽  
T Cell ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Esophagitis ◽  
Reflux Disease ◽  
Cd8 T Cell ◽  
Intraepithelial Lymphocytes ◽  
Motility Disorders ◽  
Lymphocytic Esophagitis

Context.— Published reports have suggested an association of lymphocytic esophagitis (LyE) with gastroesophageal reflux disease (GERD) and primary motility disorders and have also shown that GERD and motility disorders frequently overlap. These findings make it difficult to determine the true relationship between LyE and GERD, which may be confounded by the presence of motility disorders with LyE. Objective.— To characterize patterns of lymphocytic inflammation in patients with GERD that have no motility abnormalities. Design.— We identified 161 patients seen at our institution from 1998 to 2014, who were diagnosed with GERD, had normal esophageal motility, and available esophageal biopsies. LyE was defined as peripapillary lymphocytosis with rare or absent granulocytes. CD4 and CD8 immunophenotype of lymphocytes was evaluated using immunohistochemistry. Results.— We found increased intraepithelial lymphocytes in 13.7% of patients with GERD. Two major patterns and 1 minor pattern of lymphocytic inflammation were observed as follows: (1) LyE (in 6.8% [11 of 161] of patients and typically focal), (2) dispersed lymphocytes in an area of reflux esophagitis (in 5.6% [9 of 161] and typically diffuse), and (3) peripapillary lymphocytes in an area of reflux esophagitis (in 1.2% [2 of 161]). CD8 T cells significantly outnumbered CD4 T cells in 91% of patients with lymphocytic esophagitis and 100% of patients with dispersed lymphocytes (9 of 9) or peripapillary lymphocytes (2 of 2) in the area of reflux esophagitis. Conclusions.— These findings suggest that LyE is one of the major patterns of lymphocytic inflammation in GERD. CD8 T-cell–predominant immunophenotype may be useful as a marker of GERD in the differential diagnosis of LyE.

scholarly journals Efficacy of combined therapy in patients with erosive gastroesophageal reflux disease

2021 ◽  
Vol 5 (6) ◽  
pp. 366-372
Author(s):  
I.V. Matoshina ◽  
◽  
M.A. Livzan ◽  
M.M. Fedorin ◽  
I.V. Lapteva ◽  
...  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Esophagitis ◽  
Reflux Disease ◽  
Comparison Group ◽  
Combined Therapy ◽  
Life Quality ◽  
Main Group ◽  
Esophageal Mucosa

Aim: to evaluate the efficacy and safety of combined therapy with a proton pump inhibitor (PPI) and an esophagoprotector to relieve the symptoms of reflux esophagitis, improve the life quality of patients and achieve faster and complete disease remission. Patients and Methods: a randomized study included 60 patients, including 33 men (mean age 40.96±13.44 years) and 27 women (mean age 48.29±12.69 years) with a duration of gastroesophageal reflux disease (GERD) of 21.85±15.48 months and C/D stage of reflux esophagitis. Depending on the prescribed treatment, the patients were divided into 2 groups of 30 subjects. Patients of the main group received complex therapy: PPI pantoprazole 40 mg once per day and esophagoprotector based on hyaluronic acid, chondroitin sulfate and poloxamer 407. In the comparison group, only pantoprazole was prescribed at the same dosage. The duration of the treatment course in both groups was 4 weeks. Before and after treatment, the presence and severity of complaints were assessed on the Likert scale, life quality according to the SF-36 questionnaire and endoscopic examination data. Results: after the end of the therapy course, a statistically significant decrease in the severity of epigastric burning, regurgitation, substernal pain, gaseous eructation, odynophagia and dysphagia was found both in the main group (in all cases p<0.05, Wilcoxon Matched Pairs Test) and the comparison group (in all cases p<0,05, Wilcoxon Matched Pairs Test). The use of combination therapy made it possible to achieve a more significant improvement in the life quality of patients in all indicators versus PPI monotherapy. In addition, 3 (10%) patients of the main group achieved endoscopic remission, while there were no such patients in the comparison group. The use of esophagoprotector in addition to PPI made it possible to reach the primary and secondary endpoints significantly more commonly versus during monotherapy. Conclusion: the obtained data indicate the high efficiency and safety of PPI therapy in combination with esophagoprotector for relieving the disease symptoms and improving the life quality of patients, faster and complete remission of reflux esophagitis by additional restoration of the esophageal mucosa resistance. Esophagoprotector as a component of complex therapy together with PPI allows achieving clinical and endoscopic disease remission in patients with erosive esophagitis in shorter terms. KEYWORDS: gastroesophageal reflux disease, esophageal mucosa resistance, esophagoprotection, proton pump inhibitor, quality of life. FOR CITATION: Matoshina I.V., Livzan M.A., Fedorin M.M., Lapteva I.V. Efficacy of combined therapy in patients with erosive gastroesophageal reflux disease. Russian Medical Inquiry. 2021;5(6):366–372 (in Russ.). DOI: 10.32364/2587-6821-2021-5-6-366-372.

Reflux Esophagitis: A Cause of Globus

1981 ◽  
Vol 89 (5) ◽  
pp. 780-782 ◽  
Author(s):  
Alex Weisskopf
Keyword(s):  
Gastroesophageal Reflux ◽  
Reflux Esophagitis

It has been discovered that many of the vague throat symptoms designated as globus are due to gastroesophageal reflux. Several illustrative cases are reported to demonstrate the gamut of symptoms that may be encountered and their means of control.

Reflux Esophagitis in Three Cats Associated With Metaplastic Columnar Esophageal Epithelium

2006 ◽  
Vol 42 (1) ◽  
pp. 65-70 ◽  
Author(s):  
Massimo Gualtieri ◽  
Daniela Olivero
Keyword(s):  
Gastroesophageal Reflux ◽  
Reflux Esophagitis ◽  
Squamous Epithelium ◽  
Clinical Signs ◽  
Columnar Epithelium ◽  
Esophageal Mucosa ◽  
Esophageal Epithelium ◽  
Sliding Hiatal Hernia ◽  
Underlying Causes ◽  
Chronic Esophagitis

Gastroesophageal reflux is a relatively common condition in dogs and cats and may lead to secondary reflux esophagitis. A consequence of chronic gastroesophageal reflux that is well described in humans is Barrett’s esophagus, which is the replacement of the normal squamous epithelium of the distal esophagus with metaplastic columnar epithelium. Three cats with clinical and endoscopic signs of chronic esophagitis had metaplastic columnar epithelium on biopsy of the distal esophageal mucosa. Suspected underlying causes were cardial incompetence and sliding hiatal hernia. Two cats had complete resolution of the clinical signs after treatment. One cat was euthanized.

Mechanisms of Gastroesophageal Reflux in Patients with Reflux Esophagitis

1982 ◽  
Vol 307 (25) ◽  
pp. 1547-1552 ◽  
Author(s):  
Wylie J. Dodds ◽  
John Dent ◽  
Walter J. Hogan ◽  
James F. Helm ◽  
Richard Hauser ◽  
...  
Keyword(s):  
Gastroesophageal Reflux ◽  
Reflux Esophagitis

scholarly journals Clinical and endoscopic features of gastroesophageal reflux disease in patients with obesity

2019 ◽  
Vol 2 (13) ◽  
pp. 49-51
Author(s):  
Ye. S. Sirchak ◽  
M. P. Stan ◽  
Yo. I. Pichkar ◽  
S. S. Sirchak
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Esophagitis ◽  
Reflux Disease ◽  
Clinical Manifestations ◽  
Duodenogastric Reflux ◽  
Clinical Form ◽  
Endoscopic Study ◽  
High Incidence

Clinical and endoscopic results of a study at 94 patients with gastroesophageal reflux disease (GERD) and obesity, as well as 85 patients with GERD are presented. A high incidence of atypical clinical manifestations of GERD on the background of obesity (an extraesophageal form of the disease) was revealed. An endoscopic study has mainly established reflux esophagitis of grades B and C (LA) in patients with obesity and a high percentage of cases (up to 59.5%) of duodenogastric reflux with a combination of GERD and obesity, especially in patients with atypical clinical form of reflux disease.

scholarly journals EFFICACY OF PROTON PUMP INHIBITORS IN CHILDREN WITH ASTHMA COMBINED WITH GASTROESOPHAGEAL REFLUX DISEASE AND REFLUX ESOPHAGITIS

2021 ◽  
Vol 2021 (4) ◽  
pp. 21-26
Author(s):  
Yu. G. Antipkin ◽  
V. F. Lapshin ◽  
T. R. Umanets ◽  
А. А. Buratynska ◽  
N. G. Chumachenko ◽  
...  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Asthma Control ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Reflux Esophagitis ◽  
Reflux Disease ◽  
Complete Regression ◽  
Significant Difference ◽  
Children With Asthma

EFFICACY OF PROTON PUMP INHIBITORS IN CHILDREN WITH ASTHMA COMBINED WITH GASTROESOPHAGEAL REFLUX DISEASE AND REFLUX ESOPHAGITIS Yu. G. Antipkin, V. F. Lapshin, T. R. Umanets, А. А. Buratynska, N. G. Chumachenko, L. S. Stepanova, S. I. Tolkach O. Lukyanova Institute of Pediatrics, Obstetrics and Gynecology National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine Abstract. The most common comorbid pathology in children with asthma is gastroesophageal reflux disease associated with reflux esophagitis, which ranges from 32 % to 80 %. To date, the effectiveness of proton pump inhibitors in this category of children and their effect on the level of asthma control remains controversial. The aim is to study the effectiveness of treatment with proton pump inhibitors in children with asthma, combined with gastroesophageal reflux disease and reflux esophagitis. Materials and methods. Forty-six children aged 6–17 years with asthma combined with gastroesophageal reflux disease and reflux esophagitis were examined. They were taking omeprazole 20 mg once daily for 4-8 weeks to control the symptoms of gastroesophageal dysfunction. Criteria for the effectiveness of the prescribed treatment were the dynamics of symptoms of gastroesophageal reflux disease and the level of asthma control, which were assessed at 4 and 8 weeks of treatment. Assessment of symptoms of gastroesophageal reflux disease was performed according to the questionnaire. The degree of control of asthma was determined using the Asthma Control Test. Results and discussion. There was a complete regression of symptoms of gastroesophageal reflux disease after 4 weeks of treatment with omeprazole in 40 (87.0 %) patients. Only 6 (46.2 %) patients with severe asthma had episodic symptoms of gastroesophageal dysfunction after 4 weeks of omeprazole treatment that were not recorded at 8 weeks of treatment. An increase in the number of children with controlled asthma was observed with omeprazole treatment, but no significant difference was found. Conclusions. Proton pump inhibitors are effective in controlling the symptoms of gastroesophageal reflux disease in children with asthma, but not likely in the short-term level of asthma control. Key words: asthma, treatment, children, reflux esophagitis, gastroesophageal reflux disease.

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