Chronic diseases (CD) are one of the most critical problems of the twenty-first century. CDs and health conditions are incredibly varied, ranging from asthma, cardiovascular to arthritis to diabetes and from cancers to epilepsy and chronic obstructive pulmonary disease (COPD). Healthcare systems face challenges delivering care across the globe and the premature deaths of an estimated number of 550,000 working-age people across European Union countries is caused by chronic diseases, including heart attacks, strokes, diabetes and cancer. The chapter focuses on the implementation and use of new te-health system and applications as well as the holistic knowledge triangle innovation for enforcing Research, Education, ICT and medical/healthcare sector. The overall aim of this study is to describe and analyses the main different key contribution of education, research and the health sector professional to innovate and develop the te-health and other healthcare services to ensure that the patients experience a full safety life.