Next Generation of Engineering Methods and Tools for SOA-Based Large-Scale and Distributed Process Applications

2014 ◽  
pp. 137-165 ◽  
Author(s):  
Robert Harrison ◽  
C. Stuart McLeod ◽  
Giacomo Tavola ◽  
Marco Taisch ◽  
Armando W. Colombo ◽  
...  
Keyword(s):  
Large Scale ◽  
Next Generation ◽  
Distributed Process

Next-Generation Sequencing: An Emerging Tool for Drug Designing

2019 ◽  
Vol 25 (31) ◽  
pp. 3350-3357 ◽  
Author(s):  
Pooja Tripathi ◽  
Jyotsna Singh ◽  
Jonathan A. Lal ◽  
Vijay Tripathi
Keyword(s):  
Next Generation Sequencing ◽  
High Throughput ◽  
Large Scale ◽  
Massively Parallel Sequencing ◽  
Genomic Research ◽  
Biological Research ◽  
Next Generation ◽  
Human Welfare ◽  
Drug Designing ◽  
Generation Sequencing

Background: With the outbreak of high throughput next-generation sequencing (NGS), the biological research of drug discovery has been directed towards the oncology and infectious disease therapeutic areas, with extensive use in biopharmaceutical development and vaccine production. Method: In this review, an effort was made to address the basic background of NGS technologies, potential applications of NGS in drug designing. Our purpose is also to provide a brief introduction of various Nextgeneration sequencing techniques. Discussions: The high-throughput methods execute Large-scale Unbiased Sequencing (LUS) which comprises of Massively Parallel Sequencing (MPS) or NGS technologies. The Next geneinvolved necessarily executes Largescale Unbiased Sequencing (LUS) which comprises of MPS or NGS technologies. These are related terms that describe a DNA sequencing technology which has revolutionized genomic research. Using NGS, an entire human genome can be sequenced within a single day. Conclusion: Analysis of NGS data unravels important clues in the quest for the treatment of various lifethreatening diseases and other related scientific problems related to human welfare.

Evaluation of Chemical Bonding States in Multilayer Interconnect Structures for Thermal Management in Next Generation Very Large Scale Integration

2021 ◽  
Vol MA2021-02 (30) ◽  
pp. 944-944
Author(s):  
Keita Sahara ◽  
Ryo Yokogawa ◽  
Tappei Nishihara ◽  
Naomi Sawamoto ◽  
Tianzhuo Zhan ◽  
...  
Keyword(s):  
Thermal Management ◽  
Chemical Bonding ◽  
Large Scale ◽  
Very Large Scale Integration ◽  
Next Generation ◽  
Large Scale Integration ◽  
Scale Integration

scholarly journals NGS-QCbox and Raspberry for Parallel, Automated and Rapid Quality Control Analysis of Large-Scale Next Generation Sequencing (Illumina) Data

PLoS ONE ◽  
2015 ◽  
Vol 10 (10) ◽  
pp. e0139868 ◽  
Author(s):  
Mohan A. V. S. K. Katta ◽  
Aamir W. Khan ◽  
Dadakhalandar Doddamani ◽  
Mahendar Thudi ◽  
Rajeev K. Varshney
Keyword(s):  
Quality Control ◽  
Next Generation Sequencing ◽  
Large Scale ◽  
Control Analysis ◽  
Next Generation ◽  
Quality Control Analysis ◽  
Illumina Data ◽  
Generation Sequencing

scholarly journals LICENSED ANTHRAX VACCINES AND EXPERIMENTAL PREPARATIONS AT THE STAGE OF CLINICAL TRIALS

2017 ◽  
pp. 112-126
Author(s):  
N. I. Mikshis ◽  
P. Yu. Popova ◽  
A. P. Semakova ◽  
V. V. Kutyrev
Keyword(s):  
Clinical Trials ◽  
Russian Federation ◽  
Large Scale ◽  
Next Generation ◽  
The World ◽  
High Pathogenicity ◽  
The Russian Federation ◽  
Manufacturing Technologies ◽  
Anthrax Vaccines ◽  
Epidemiological Situation

High pathogenicity of anthrax agent combined with unique insensitivity of its spore forms to environmental stresses class it among extremely dangerous biological agents. Registered and effectively used anthrax vaccines made invaluable contribution to the improvement of epidemiological situation around the world. Nevertheless, neglect of non-specific prophylaxis may result in dramatic scenarios and require large-scale measures on rectification of the consequences. Efforts on the development of next-generation vaccines are aimed at safety build-up, decrease in frequency of administration, and enhancement of manufacturing technologies. The review contains the key information on licensed anthrax vaccines designed for medical use, both in the territory of the Russian Federation and abroad. Among multiple experimental developments emphasized have been preparations manufactured by various biopharmaceutical companies in compliance with GMP standards, at different phases of clinical trials in 2016.

scholarly journals Next Generation Middleware Technology for Mobile Computing

2011 ◽  
pp. 74-80
Author(s):  
B. Darsana ◽  
Karabi Konar
Keyword(s):  
Mobile Computing ◽  
Large Scale ◽  
Network Connectivity ◽  
Distributed Applications ◽  
Mobile Systems ◽  
Portable Devices ◽  
Next Generation ◽  
Mobile Middleware ◽  
Mobile Computing Environment ◽  
Middleware Technology

Current advances in portable devices, wireless technologies, and distributed systems have created a mobile computing environment that is characterized by a large scale of dynamism. Diversities in network connectivity, platform capability, and resource availability can significantly affect the application performance. Traditional middleware systems are not prepared to offer proper support for addressing the dynamic aspects of mobile systems. Modern distributed applications need a middleware that is capable of adapting to environment changes and that supports the required level of quality of service. This paper represents the experience of several research projects related to next generation middleware systems. We first indicate the major challenges in mobile computing systems and try to identify the main requirements for mobile middleware systems. The different categories of mobile middleware technologies are reviewed and their strength and weakness are analyzed.

Wavelength Division Multiplexed Passive Optical Networks

2010 ◽  
pp. 68-101
Author(s):  
Calvin C.K. Chan
Keyword(s):  
Optical Networks ◽  
Large Scale ◽  
Driving Forces ◽  
Optical Network ◽  
Access Network ◽  
High Capacity ◽  
Next Generation ◽  
Wavelength Division ◽  
Wavelength Division Multiplexed ◽  
Capacity Data

Wavelength division multiplexed passive optical network has emerged as a promising solution to support a robust and large-scale next generation optical access network. It offers high-capacity data delivery and flexible bandwidth provisioning to all subscribers, so as to meet the ever-increasing bandwidth requirements as well as the quality of service requirements of the next generation broadband access networks. The maturity and reduced cost of the WDM components available in the market are also among the major driving forces to enhance the feasibility and practicality of commercial deployment. In this chapter, the author will provide a comprehensive discussion on the basic principles and network architectures for WDM-PONs, as well as their various enabling technologies. Different feasible approaches to support the two-way transmission will be discussed. It is believed that WDM-PON is an attractive solution to realize fiber-to-the-home (FTTH) applications.

scholarly journals Applications of Next-Generation Sequencing for Large-Scale Pathogen Diagnoses in Soybean

Plant Disease ◽  
2019 ◽  
Vol 103 (6) ◽  
pp. 1075-1083 ◽  
Author(s):  
Gustavo A. Díaz-Cruz ◽  
Charlotte M. Smith ◽  
Kiana F. Wiebe ◽  
Sachi M. Villanueva ◽  
Adam R. Klonowski ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Pseudomonas Syringae ◽  
Large Scale ◽  
Fold Increase ◽  
Yellow Mosaic Virus ◽  
Growth Stages ◽  
Sequence Information ◽  
Next Generation ◽  
Leaf Sample ◽  
Generation Sequencing

Soybean (Glycine max) has become an important crop in Manitoba, Canada, with a 10-fold increase in dedicated acreage over the past decade. Given the rapid increase in production, scarce information about foliar diseases present in the province has been recorded. In order to describe the foliar pathogens affecting this legume, we harnessed next-generation sequencing (NGS) to carry out a comprehensive survey across Manitoba in 2016. Fields were sampled during the V2/3 (33 fields) and R6 (70 fields) growth stages, with at least three symptomatic leaves per field collected and subjected to RNA sequencing. We successfully detected several bacteria, fungi, and viruses known to infect soybean, including Pseudomonas savastanoi pv. glycinea, Septoria glycines, and Peronospora manshurica, as well as pathogens not previously identified in the province (e.g., Pseudomonas syringae pv. tabaci, Cercospora sojina, and Bean yellow mosaic virus). For some microorganisms, we were able to disentangle the different pathovars present and/or assemble their genome sequence. Since NGS generates data on the entire flora and fauna occupying a leaf sample, we also identified residual pathogens (i.e., pathogens of crops other than soybean) and multiple species of arthropod pests. Finally, the sequence information produced by NGS allowed for the development of polymerase chain reaction-based diagnostics for some of the most widespread and important pathogens. Although there are many benefits of using NGS for large-scale plant pathogen diagnoses, we also discuss some of the limitations of this technology.

scholarly journals Validation of variants using cost effective highresolution melting (HRM) analysis predicted from target re-sequencing in Eucalyptus

2020 ◽  
Vol 79 (2) ◽  
pp. 105-113
Author(s):  
Abdul Bari Muneera Parveen ◽  
Divya Lakshmanan ◽  
Modhumita Ghosh Dasgupta
Keyword(s):  
Next Generation Sequencing ◽  
Large Scale ◽  
Sequence Data ◽  
Cost Effective ◽  
Nucleotide Polymorphisms ◽  
Next Generation ◽  
Time Saving ◽  
Hrm Analysis ◽  
The Cost ◽  
Generation Sequencing

The advent of next-generation sequencing has facilitated large-scale discovery and mapping of genomic variants for high-throughput genotyping. Several research groups working in tree species are presently employing next generation sequencing (NGS) platforms for marker discovery, since it is a cost effective and time saving strategy. However, most trees lack a chromosome level genome map and validation of variants for downstream application becomes obligatory. The cost associated with identifying potential variants from the enormous amount of sequence data is a major limitation. In the present study, high resolution melting (HRM) analysis was optimized for rapid validation of single nucleotide polymorphisms (SNPs), insertions or deletions (InDels) and simple sequence repeats (SSRs) predicted from exome sequencing of parents and hybrids of Eucalyptus tereticornis Sm. ? Eucalyptus grandis Hill ex Maiden generated from controlled hybridization. The cost per data point was less than 0.5 USD, providing great flexibility in terms of cost and sensitivity, when compared to other validation methods. The sensitivity of this technology in variant detection can be extended to other applications including Bar-HRM for species authentication and TILLING for detection of mutants.

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