Transcriptomics of the Host–Pathogen Interaction in Paracoccidioidomycosis

Author(s):  
Patrícia Albuquerque ◽  
Hugo Costa Paes ◽  
Aldo Henrique Tavares ◽  
Larissa Fernandes ◽  
Anamélia Lorenzetti Bocca ◽  
...  
Pathogens ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 905
Author(s):  
Estela Ruiz-Baca ◽  
Armando Pérez-Torres ◽  
Yolanda Romo-Lozano ◽  
Daniel Cervantes-García ◽  
Carlos A. Alba-Fierro ◽  
...  

The role of immune cells associated with sporotrichosis caused by Sporothrix schenckii is not yet fully clarified. Macrophages through pattern recognition receptors (PRRs) can recognize pathogen-associated molecular patterns (PAMPs) of Sporothrix, engulf it, activate respiratory burst, and secrete pro-inflammatory or anti-inflammatory biological mediators to control infection. It is important to consider that the characteristics associated with S. schenckii and/or the host may influence macrophage polarization (M1/M2), cell recruitment, and the type of immune response (1, 2, and 17). Currently, with the use of new monocyte-macrophage cell lines, it is possible to evaluate different host–pathogen interaction processes, which allows for the proposal of new mechanisms in human sporotrichosis. Therefore, in order to contribute to the understanding of these host–pathogen interactions, the aim of this review is to summarize and discuss the immune responses induced by macrophage-S. schenckii interactions, as well as the PRRs and PAMPs involved during the recognition of S. schenckii that favor the immune evasion by the fungus.


2012 ◽  
Vol 8 (10) ◽  
pp. e1002933 ◽  
Author(s):  
Hanna K. de Jong ◽  
Chris M. Parry ◽  
Tom van der Poll ◽  
W. Joost Wiersinga

Plant Science ◽  
2021 ◽  
pp. 111098
Author(s):  
Nana Liu ◽  
Ping Wang ◽  
Xiancai Li ◽  
Yakun Pei ◽  
Yun Sun ◽  
...  

2017 ◽  
Vol 27 (8) ◽  
pp. 1820-1832 ◽  
Author(s):  
Jennifer Hudson ◽  
Melissa Gardiner ◽  
Nandan Deshpande ◽  
Suhelen Egan

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