Host-pathogen interaction between Asian citrus psyllid and entomopathogenic fungus (Cordyceps fumosorosea) is regulated by modulations in gene expression, enzymatic activity and HLB-bacterial population of the host

By providing useful tools to study host-pathogen interactions, next-generation omics has recently enabled the study of gene expression changes in both pathogen and infected host simultaneously. However, since great discriminative power is required to study pathogen and host simultaneously throughout the infection process, the depth of quantitative gene expression profiling has proven to be unsatisfactory when focusing on bacterial pathogens, thus preferentially requiring specific strategies or the development of novel methodologies based on complementary omics approaches. In this review, we focus on the difficulties encountered when making use of omics approaches to study bacterial pathogenesis. Besides, we review different omics strategies (i.e. transcriptomics, proteomics and secretomics) and their applications for studying interactions of pathogens with their host.

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The host-pathogen interaction between wheat and yellow rust induces temporally coordinated waves of gene expression

BMC Genomics ◽

10.1186/s12864-016-2684-4 ◽

2016 ◽

Vol 17 (1) ◽

Cited By ~ 42

Author(s):

Albor Dobon ◽

Daniel C. E. Bunting ◽

Luis Enrique Cabrera-Quio ◽

Cristobal Uauy ◽

Diane G. O. Saunders

Keyword(s):

Gene Expression ◽

Yellow Rust ◽

Host Pathogen Interaction ◽

Host Pathogen

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High-throughput Gene Expression Analysis to Investigate Host-pathogen Interaction in Avian Coccidiosis

Korean Journal of Poultry Science ◽

10.5536/kjps.2007.34.1.077 ◽

2007 ◽

Vol 34 (1) ◽

pp. 77-83

Author(s):

Hyun S. Lillehoj

Keyword(s):

Gene Expression ◽

Expression Analysis ◽

High Throughput ◽

Gene Expression Analysis ◽

Host Pathogen Interaction ◽

Host Pathogen ◽

Avian Coccidiosis ◽

High Throughput Gene Expression

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Faculty Opinions recommendation of A Novel Mechanism of Host-Pathogen Interaction through sRNA in Bacterial Outer Membrane Vesicles.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726419717.793534336 ◽

2017 ◽

Author(s):

Burkhard Tümmler

Keyword(s):

Outer Membrane ◽

Membrane Vesicles ◽

Outer Membrane Vesicles ◽

Host Pathogen Interaction ◽

Host Pathogen ◽

Bacterial Outer Membrane

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The Role of Macrophages in the Host’s Defense against Sporothrix schenckii

Pathogens ◽

10.3390/pathogens10070905 ◽

2021 ◽

Vol 10 (7) ◽

pp. 905

Author(s):

Estela Ruiz-Baca ◽

Armando Pérez-Torres ◽

Yolanda Romo-Lozano ◽

Daniel Cervantes-García ◽

Carlos A. Alba-Fierro ◽

...

Keyword(s):

Immune Responses ◽

Macrophage Polarization ◽

Sporothrix Schenckii ◽

Macrophage Cell ◽

Cell Recruitment ◽

Host Pathogen Interaction ◽

Interaction Processes ◽

Host Pathogen ◽

Molecular Patterns

The role of immune cells associated with sporotrichosis caused by Sporothrix schenckii is not yet fully clarified. Macrophages through pattern recognition receptors (PRRs) can recognize pathogen-associated molecular patterns (PAMPs) of Sporothrix, engulf it, activate respiratory burst, and secrete pro-inflammatory or anti-inflammatory biological mediators to control infection. It is important to consider that the characteristics associated with S. schenckii and/or the host may influence macrophage polarization (M1/M2), cell recruitment, and the type of immune response (1, 2, and 17). Currently, with the use of new monocyte-macrophage cell lines, it is possible to evaluate different host–pathogen interaction processes, which allows for the proposal of new mechanisms in human sporotrichosis. Therefore, in order to contribute to the understanding of these host–pathogen interactions, the aim of this review is to summarize and discuss the immune responses induced by macrophage-S. schenckii interactions, as well as the PRRs and PAMPs involved during the recognition of S. schenckii that favor the immune evasion by the fungus.

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Growth, Development, and Gene Expression in a Persistent Streptococcus gordonii Biofilm

Infection and Immunity ◽

10.1128/iai.71.8.4759-4766.2003 ◽

2003 ◽

Vol 71 (8) ◽

pp. 4759-4766 ◽

Cited By ~ 48

Author(s):

Keeta S. Gilmore ◽

Pravina Srinivas ◽

Darrin R. Akins ◽

Kenneth L. Hatter ◽

Michael S. Gilmore

Keyword(s):

Gene Expression ◽

Biofilm Formation ◽

Bacterial Population ◽

Morphological Changes ◽

Expression Patterns ◽

Nutrient Flux ◽

Gene Expression Patterns ◽

Significant Shift ◽

Streptococcus Gordonii ◽

Growth Development

ABSTRACT A model for the protracted (30-day) colonization of smooth surfaces by Streptococcus gordonii that incorporates the nutrient flux that occurs in the oral cavity was developed. This model was used to characterize the biphasic expansion of the adherent bacterial population, which corresponded with the emergence of higher-order architectures characteristic of biofilms. Biofilm formation by S. gordonii was observed to be influenced by the presence of simple sugars including sucrose, glucose, and fructose. Real-time PCR was used to quantify changes in expression of S. gordonii genes known or thought to be involved in biofilm formation. Morphological changes were accompanied by a significant shift in gene expression patterns. The majority of S. gordonii genes examined were observed to be downregulated in the biofilm phase. Genes found to be upregulated in the biofilm state were observed to encode products related to environmental sensing and signaling.

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