Stem Cell Trials for Retinal Disease: An Update

2017 ◽  
pp. 173-180
Author(s):  
Henry Klassen
Keyword(s):  
Stem Cell ◽  
Retinal Disease

Stem cell therapy for retinal disease

2012 ◽  
Vol 23 (3) ◽  
pp. 226-234 ◽  
Author(s):  
Michael D. Tibbetts ◽  
Michael A. Samuel ◽  
Tom S. Chang ◽  
Allen C. Ho
Keyword(s):  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Retinal Disease

Stem-cell therapy in retinal disease

2009 ◽  
Vol 20 (3) ◽  
pp. 175-181 ◽  
Author(s):  
Paul S Baker ◽  
Gary C Brown
Keyword(s):  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Retinal Disease

scholarly journals Induced Pluripotent Stem Cells and Outer Retinal Disease

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Jin Yang ◽  
Bingcui Cai ◽  
Patrick Glencer ◽  
Zhiqing Li ◽  
Xiaomin Zhang ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Stem Cell ◽  
Molecular Mechanisms ◽  
Disease Modeling ◽  
Posterior Part ◽  
Retinal Disease ◽  
Retinal Cell ◽  
Cell Transplant ◽  
Blood Retinal Barrier ◽  
First Choice

The retina, which is composed of multiple layers of differing cell types, has been considered the first choice for gene therapy, disease modeling, and stem cell-derived retinal cell transplant therapy. Because of its special characteristics, the retina, located in the posterior part of the eye, can be well observed directly after gene therapy or transplantation. The blood-retinal barrier is part of a specialized ocular microenvironment that is immune privileged. This protects transplanted cells and tissue. Having two eyes makes perfect natural control possible after a single eye receives gene or stem cell therapy. For this reason, research about exploring retinal diseases’ underlying molecular mechanisms and potential therapeutic approach using stem cell technique has been developing rapidly. This review is to present an up-to-date summary of the iPSC’s sources, variations, differentiation methods, and the wide-ranging application of iPSCs-RPCS or iPSCs-RPE on retinal disease modeling, diagnostics, and therapeutics.

scholarly journals Interaction Between Mesenchymal Stem Cells and Retinal Degenerative Microenvironment

2021 ◽  
Vol 14 ◽  
Author(s):  
Yu Lin ◽  
Xiang Ren ◽  
Yongjiang Chen ◽  
Danian Chen
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Vision Loss ◽  
Therapeutic Potential ◽  
Clinical Stage ◽  
Retinal Disease ◽  
Tumor Formation ◽  
Cell Based Therapy ◽  
Retinal Degenerative Diseases ◽  
Stromal Stem Cells

Retinal degenerative diseases (RDDs) are a group of diseases contributing to irreversible vision loss with yet limited therapies. Stem cell-based therapy is a promising novel therapeutic approach in RDD treatment. Mesenchymal stromal/stem cells (MSCs) have emerged as a leading cell source due to their neurotrophic and immunomodulatory capabilities, limited ethical concerns, and low risk of tumor formation. Several pre-clinical studies have shown that MSCs have the potential to delay retinal degeneration, and recent clinical trials have demonstrated promising safety profiles for the application of MSCs in retinal disease. However, some of the clinical-stage MSC therapies have been unable to meet primary efficacy end points, and severe side effects were reported in some retinal “stem cell” clinics. In this review, we provide an update of the interaction between MSCs and the RDD microenvironment and discuss how to balance the therapeutic potential and safety concerns of MSCs' ocular application.

scholarly journals Autologous stem cell therapy for inherited and acquired retinal disease

2018 ◽  
Vol 13 (1) ◽  
pp. 89-96 ◽  
Author(s):  
Mary Ben L Apatoff ◽  
Jesse D Sengillo ◽  
Eugenia C White ◽  
Mathieu F Bakhoum ◽  
Alexander G Bassuk ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Retinal Disease
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