Extraskeletal Osteogenic Sarcoma

2016 ◽  
pp. 327-334
Author(s):  
Murray F. Brennan ◽  
Cristina R. Antonescu ◽  
Kaled M. Alektiar ◽  
Robert G. Maki
Keyword(s):  
Osteogenic Sarcoma

Diagnostic Value of Electron Microscopy in Soft Tissue Tumors

1970 ◽  
Vol 28 ◽  
pp. 220-221
Author(s):  
Gerald Fine ◽  
Azorides R. Morales
Keyword(s):  
Cardiac Myxoma ◽  
Osteogenic Sarcoma ◽  
Diagnostic Value ◽  
Soft Tissue Tumors ◽  
Amelanotic Melanoma ◽  
Growth Patterns ◽  
Light Microscopic Level ◽  
Mesenchymal Tumors ◽  
Good Agreement

For years the separation of carcinoma and sarcoma and the subclassification of sarcomas has been based on the appearance of the tumor cells and their microscopic growth pattern and information derived from certain histochemical and special stains. Although this method of study has produced good agreement among pathologists in the separation of carcinoma from sarcoma, it has given less uniform results in the subclassification of sarcomas. There remain examples of neoplasms of different histogenesis, the classification of which is questionable because of similar cytologic and growth patterns at the light microscopic level; i.e. amelanotic melanoma versus carcinoma and occasionally sarcoma, sarcomas with an epithelial pattern of growth simulating carcinoma, histologically similar mesenchymal tumors of different histogenesis (histiocytoma versus rhabdomyosarcoma, lytic osteogenic sarcoma versus rhabdomyosarcoma), and myxomatous mesenchymal tumors of diverse histogenesis (myxoid rhabdo and liposarcomas, cardiac myxoma, myxoid neurofibroma, etc.)

Virus-Like Particles in a Human Breast Cancer: Structural Similarity to Previously Reported Particles

1973 ◽  
Vol 31 ◽  
pp. 378-379
Author(s):  
G. Kasnic ◽  
S. E. Stewart ◽  
C. Urbanski
Keyword(s):  
Breast Cancer ◽  
Biological Activity ◽  
Human Breast Cancer ◽  
Osteogenic Sarcoma ◽  
Human Tumor ◽  
Structural Similarity ◽  
Cell Tumor ◽  
Human Breast ◽  
Human Tumor Cell ◽  
Type Particle

We have reported the maturation of an intracisternal A-type particle in murine plasma cell tumor cultures and three human tumor cell cultures (rhabdomyosarcoma, lung adenocarcinoma, and osteogenic sarcoma) after IUDR-DMSO activation. In all of these studies the A-type particle seems to develop into a form with an electron dense nucleoid, presumably mature, which is also intracisternal. A similar intracisternal A-type particle has been described in leukemic guinea pigs. Although no biological activity has yet been demonstrated for these particles, on morphologic grounds, and by the manner in which they develop within the cell, they may represent members of the same family of viruses.

Malignant Disease of the Osseous Adnexae: Osteogenic Sarcoma of the Jaws

1979 ◽  
Vol 12 (1) ◽  
pp. 129-134
Author(s):  
Hugh O. deFries ◽  
Alan D. Kornblut
Keyword(s):  
Malignant Disease ◽  
Osteogenic Sarcoma

Radiation-Induced Osteogenic Sarcoma Presenting as a Recurrent Melanoma in the Left Orbital Area

Skull Base ◽  
2007 ◽  
Vol 17 (S 1) ◽  
Author(s):  
Il Young Shin ◽  
Yong Gu Chung ◽  
Dong Huyk Park ◽  
Hoon Gab Lee
Keyword(s):  
Osteogenic Sarcoma ◽  
Radiation Induced ◽  
Orbital Area

Radiological analysis of intraarterial chemotherapeutic effects in osteogenic sarcoma: focussed on MRI and IA DSA findings

1991 ◽  
Vol 27 (5) ◽  
pp. 715
Author(s):  
Goo Lee ◽  
In One Kim ◽  
Kyung Mo Yeon ◽  
Hyun Ki Yoon ◽  
Hyo Seop Ahn
Keyword(s):  
Osteogenic Sarcoma ◽  
Radiological Analysis

THE TREATMENT OF OSTEOGENIC SARCOMA OF THE MANDIBLE

1967 ◽  
Vol 99 (2) ◽  
pp. 326-332 ◽  
Author(s):  
CARL W. BOYER ◽  
THEODORE J. BRICKNER ◽  
GARY P. WRATTEN
Keyword(s):  
Osteogenic Sarcoma

Modulation of glucose transport by parathyroid hormone and insulin in UMR 106–01, a clonal rat osteogenic sarcoma cell line

1995 ◽  
Vol 14 (2) ◽  
pp. 263-275 ◽  
Author(s):  
D M Thomas ◽  
S D Rogers ◽  
M W Sleeman ◽  
G M Pasquini ◽  
F R Bringhurst ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Cell Line ◽  
Glucose Transport ◽  
Transport System ◽  
Osteogenic Sarcoma ◽  
Regulatory Subunit ◽  
Sarcoma Cell ◽  
Sarcoma Cell Line ◽  
Glucose Transport System ◽  
Umr 106

ABSTRACT This study characterizes the actions of insulin and parathyroid hormone (PTH) on the glucose transport system in the rat osteogenic sarcoma cell line UMR 106–01, which expresses a number of features of the osteoblast phenotype. Using [1,2-3H]2-deoxyglucose (2-DOG) as a label, UMR 106–01 cells were shown to possess a glucose transport system which was enhanced by insulin. In contrast, PTH influenced glucose transport in a biphasic manner with a stimulatory effect at 1 h and a more potent inhibitory effect at 16 h on basal and insulin-stimulated 2-DOG transport. To explore the mechanism of PTH action, a direct agonist of cAMP-dependent protein kinase (PKA) was tested. 8-Bromo-cAMP had no acute stimulatory effect but inhibited basal and insulin-stimulated 2-DOG transport at 16 h. This result suggested that the prolonged, but not the acute, effect of PTH was mediated by the generation of cAMP. Further studies with the cell line UMR 4–7, a UMR 106–01 clone stably transfected with an inducible mutant inactive regulatory subunit of PKA, confirmed that the inhibitory but not the stimulatory effect of PTH was mediated by the PKA pathway. Northern blot data indicated that the prolonged inhibitory effects of PTH and 8-bromo-cAMP on glucose transport were likely to be mediated in part by reduction in the levels of GLUT1 (HepG2/brain glucose transporter) mRNA.

Survival Following Aggressive Resection of Pulmonary Metastases from Osteogenic Sarcoma: Analysis of Prognostic Factors

1983 ◽  
Vol 36 (5) ◽  
pp. 516-523 ◽  
Author(s):  
Joe B. Putnam ◽  
Jack A. Roth ◽  
Margaret N. Wesley ◽  
Michael R. Johnston ◽  
Steven A. Rosenberg
Keyword(s):  
Prognostic Factors ◽  
Pulmonary Metastases ◽  
Osteogenic Sarcoma

Osteosarcoma (osteogenic sarcoma) of the jaws presenting in general dental practice - a series of four cases

BDJ ◽  
2021 ◽  
Vol 230 (9) ◽  
pp. 583-586
Author(s):  
Liam Costello ◽  
Mary Toner ◽  
Dermot Pierse ◽  
Leo F. A. Stassen
Keyword(s):  
Osteogenic Sarcoma ◽  
Dental Practice ◽  
General Dental Practice

scholarly journals Analysis of a Preliminary microRNA Expression Signature in a Human Telangiectatic Osteogenic Sarcoma Cancer Cell Line

2021 ◽  
Vol 22 (3) ◽  
pp. 1163
Author(s):  
Gaia Palmini ◽  
Cecilia Romagnoli ◽  
Simone Donati ◽  
Roberto Zonefrati ◽  
Gianna Galli ◽  
...  
Keyword(s):  
Cell Line ◽  
Molecular Mechanisms ◽  
Osteogenic Sarcoma ◽  
Cancer Cell Line ◽  
Microscopic Features ◽  
In Vitro Establishment ◽  
Profile Characteristic ◽  
First Time

Telangiectatic osteosarcoma (TOS) is an aggressive variant of osteosarcoma (OS) with distinctive radiographic, gross, microscopic features, and prognostic implications. Despite several studies on OS, we are still far from understanding the molecular mechanisms of TOS. In recent years, many studies have demonstrated not only that microRNAs (miRNAs) are involved in OS tumorigenesis, development, and metastasis, but also that the presence in high-grade types of OS of cancer stem cells (CSCs) plays an important role in tumor progression. Despite these findings, nothing has been described previously about the expression of miRNAs and the presence of CSCs in human TOS. Therefore, we have isolated/characterized a putative CSC cell line from human TOS (TOS-CSCs) and evaluated the expression levels of several miRNAs in TOS-CSCs using real-time quantitative assays. We show, for the first time, the existence of CSCs in human TOS, highlighting the in vitro establishment of this unique stabilized cell line and an identification of a preliminary expression of the miRNA profile, characteristic of TOS-CSCs. These findings represent an important step in the study of the biology of one of the most aggressive variants of OS and the role of miRNAs in TOS-CSC behavior.

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