Rarity of Mixed Species Malaria with Plasmodium falciparum and Plasmodium malariae in Travelers to Saarland in Germany

2017 ◽  
pp. 35-45
Author(s):  
Josef Yayan ◽  
Kurt Rasche
Keyword(s):  
Plasmodium Falciparum ◽  
Plasmodium Malariae ◽  
Mixed Species

The Blood-stage Dynamics of Mixed Plasmodium malariae–Plasmodium falciparum Infections

1999 ◽  
Vol 198 (4) ◽  
pp. 549-566 ◽  
Author(s):  
Daniel P Mason ◽  
F.Ellis McKenzie ◽  
William H Bossert
Keyword(s):  
Plasmodium Falciparum ◽  
Plasmodium Malariae ◽  
Blood Stage

scholarly journals How prevalent is Plasmodium malariae in Rondônia, Western Brazilian Amazon?

2000 ◽  
Vol 33 (5) ◽  
pp. 489-492 ◽  
Author(s):  
Marisa Torres Vidal Cavasini ◽  
Weber Luidi Ribeiro ◽  
Fumihiko Kawamoto ◽  
Marcelo Urbano Ferreira
Keyword(s):  
Polymerase Chain Reaction ◽  
Plasmodium Species ◽  
Brazilian Amazon ◽  
Plasmodium Malariae ◽  
Mixed Species ◽  
Chain Reaction ◽  
Nested Polymerase Chain Reaction ◽  
Polymerase Chain ◽  
Potential Impact ◽  
And Control

We have compared results of Plasmodium species identification obtained with conventional on-site microscopy of Giemsa-stained thick smears (GTS) and a semi-nested polymerase chain reaction (PCR) in 96 malaria patients from Rondônia, Western Brazilian Amazon. Mixed-species infections were detected by PCR in 30% patients, but no such case had been found on GTS. Moreover, P. malariae infections were detected in 9 of 96 patients (10%) by PCR, but were not identified by local microscopists. The potential impact of species misidentification on malaria treatment and control is discussed.

scholarly journals Persistent transmission of Plasmodium malariae and Plasmodium ovale species in an area of declining Plasmodium falciparum transmission in eastern Tanzania

2019 ◽  
Vol 13 (5) ◽  
pp. e0007414 ◽  
Author(s):  
Victor Yman ◽  
Grace Wandell ◽  
Doreen D. Mutemi ◽  
Aurelie Miglar ◽  
Muhammad Asghar ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Plasmodium Malariae ◽  
Plasmodium Ovale

scholarly journals Plasmodium falciparum DHFR and DHPS Mutations Are Associated With HIV-1 Co-Infection and a Novel DHPS Mutation I504T Is Identified in Western Kenya

2020 ◽  
Vol 10 ◽  
Author(s):  
Brandi K. Torrevillas ◽  
Sarah M. Garrison ◽  
Alexander J. McKeeken ◽  
Dharmeshkumar Patel ◽  
James T. Van Leuven ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Haplotype Diversity ◽  
Plasmodium Malariae ◽  
Drug Binding ◽  
Cross Resistance ◽  
Asymptomatic Malaria ◽  
Newly Diagnosed ◽  
Cross Sectional ◽  
Antifolate Resistance ◽  
Hiv 1

Antifolate resistance is significant in Kenya and presumed to result from extensive use and cross-resistance between antifolate antimalarials and antibiotics, including cotrimoxazole/Bactrim used for HIV-1 chemotherapy. However, little is known about antifolate-resistant malaria in the context of newly diagnosed HIV-1 co-infection prior to administration of HIV-1 chemotherapy. Blood samples from a cross-sectional study of asymptomatic adult Kenyans enrolled during voluntary HIV testing were analyzed by PCR for Plasmodium spp. More than 95% of volunteers with identifiable parasite species (132 HIV-1 co-infected) were infected with Plasmodium falciparum alone or P. falciparum with Plasmodium ovale and/or Plasmodium malariae. Deep sequencing was used to screen for mutations in P. falciparum dihydrofolate reductase (dhfr) (N51I, C59R, S108N, I164L) and dihydropteroate synthase (dhps) (S436H, A437G, K540E, A581G) from 1133 volunteers. Individual mutations in DHPS but not DHFR correlated with HIV-1 status. DHFR haplotype diversity was significantly different among volunteers by gender and HIV-1 status. DHPS haplotype diversity by HIV-1 status was significantly different between volunteers paired by age and gender, indicating that patterns of resistance were independent of these variables. Molecular simulations for a novel DHPS mutation (I504T) suggested that the mutated protein has increased affinity for the endogenous ligand DHPPP and decreased affinity for drug binding. A sub-group of monoclonal infections revealed that age and parasitemia were not correlated and enabled identification of a rare septuple-mutant haplotype (IRNL-HGEA). In our study, adult Kenyans newly diagnosed with HIV-1 infection were predominantly infected with moderately resistant P. falciparum, with patterns of infecting parasite genotypes significantly associated with HIV-1 status. Together with the discovery of DHPS I504T, these data indicate that antifolate resistance continues to evolve in Kenya. Further, they highlight the need to understand the effects of associated mutations on both fitness and resistance of P. falciparum in the context of HIV-1 co-infection to better inform treatment for asymptomatic malaria.

scholarly journals Infección mixta por Plasmodium falciparum y Plasmodium malariae: Valor de las técnicas de diagnóstico molecular

2008 ◽  
Vol 25 (3) ◽  
Author(s):  
J. Campos Franco ◽  
J. Llovo Taboada ◽  
R. López Rodríguez ◽  
N. Mallo González ◽  
S. Cortizo Vidal ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Plasmodium Malariae
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