Hepatitis A and E in South America: New Challenges Toward Prevention and Control

2017 ◽  
pp. 119-138 ◽  
Author(s):  
Marcelo Alves Pinto ◽  
Jaqueline Mendes de Oliveira ◽  
Jorge González
Keyword(s):  
South America ◽  
Prevention And Control ◽  
Hepatitis A ◽  
New Challenges ◽  
And Control

scholarly journals Semi-Synthesis of Marine-Derived Ilamycin F Derivatives and Their Antitubercular Activities

2021 ◽  
Vol 9 ◽  
Author(s):  
Jun Li ◽  
Zhiyong Liu ◽  
Mingye Hong ◽  
Changli Sun ◽  
Tianyu Zhang ◽  
...  
Keyword(s):  
Prevention And Control ◽  
Inhibitory Concentration ◽  
Drug Resistant ◽  
Structure Activity ◽  
The World ◽  
Resistant Strains ◽  
New Challenges ◽  
Low Cytotoxicity ◽  
Drug Resistant Strains ◽  
And Control

Tuberculosis (TB) is still a global disease threatening people’s lives. With the emergence of multi-drug-resistant Mycobacterium tuberculosis the prevention and control of tuberculosis faces new challenges, and the burden of tuberculosis treatment is increasing among the world. Ilamycins are novel cyclopeptides with potent anti-TB activities, which have a unique target protein against M. tuberculosis and drug-resistant strains. Herein, ilamycin F, a major secondary metabolite isolated from the marine-derived mutant strain Streptomyces atratus SCSIO ZH16 ΔilaR, is used as a scaffold to semi-synthesize eighteen new ilamycin derivatives (ilamycin NJL1–NJL18, 1–18). Our study reveals that four of ilamycin NJLs (1, 6, 8, and 10) have slightly stronger anti-TB activities against Mtb H37Rv (minimum inhibitory concentration, 1.6–1.7 μM) compared with that of ilamycin F on day 14th, but obviously display more potent activities than ilamycin F on day 3rd, indicating anti-TB activities of these derivatives with fast-onset effect. In addition, cytotoxic assays show most ilamycin NJLs with low cytotoxicity except ilamycin NJL1 (1). These findings will promote the further exploration of structure-activity relationships for ilamycins and the development of anti-TB drugs.

scholarly journals Global burden of COVID-19: Situational analyis and review

2020 ◽  
pp. 1-10
Author(s):  
Addis Adera Gebru ◽  
Tadesse Birhanu ◽  
Eshetu Wendimu ◽  
Agumas Fentahun Ayalew ◽  
Selamawit Mulat ◽  
...  
Keyword(s):  
Public Health ◽  
North America ◽  
South America ◽  
Prevention And Control ◽  
Public Health Burden ◽  
Health Burden ◽  
Online Databases ◽  
Review Period ◽  
The World ◽  
And Control

BACKGROUND: The novel Coronavirus Diseases 2019 (COVID-19) is the major public health burden in the world. The morbidity and mortality of global community due to this disease is dramatically increasing from time to time. OBJECTIVE: This situational analysis is aimed to analysis prevalence, and incidence of COVID-19 and to provide clear information about this disease for the scientific community, stakeholders and healthcare practitioners and decision-makers. METHODS: The literatures were identified by searching the key relevant and officially known online databases: medRxiv, Google scholar and PubMed. The online databases contain archives of most English biomedical journals and scientific papers published online from 31 December to 3 April 2020 were included. After the literature search, articles were screened independently by two reviewers for eligibility. RESULTS: The world continents have confirmed a total of 1,202,320 confirmed COVID-19 cases: (51.2%) in Europe, (27.7%) in North America, (17.9%) in Asia, (1.96%) in South America and at less number of confirmed COVID-19 cases in Africa and Australia which was accounted 0.8% and 0.5%, respectively. However, this review showed that there was significantly increased the confirmed COVID-19 cases by 109,555 in Asia, 8,658 in Africa, 332,866 in North America, 20,269 in South America, 568,894 in Europe, 5,051 in Australia and 1,045,403 in the whole world continent except Antarctica during the review period. The overall results showed that there were 1,098,762 cases and 59,172 deaths have recorded from during the review period. The result zero number of deaths with COVID-19 was observed in 66 countries. CONCLUSION: The review concluded that COVID-19; SARS-CoV-2 is the major public health burden in the world, the morbidity and mortality of global community is dramatically increasing from time to time. Strongly collaboration among all sectors and then design effective prevention and control strategies which include staying home, social/physical distancing, quarantine, testing of suspected patients, isolation and managing of the confirmed cases. Therefore, the world continents countries should have to implement five major COVID-19 prevention and control programmes as soon as possible at community level.

From genomics to surveillance, prevention and control: New challenges for the African meningitis belt

Vaccine ◽  
2006 ◽  
Vol 24 (20) ◽  
pp. 4279-4284 ◽  
Author(s):  
Jean-Michel Alonso ◽  
Eric Bertherat ◽  
William Perea ◽  
Ray Borrow ◽  
Suzanne Chanteau ◽  
...  
Keyword(s):  
Prevention And Control ◽  
Meningitis Belt ◽  
New Challenges ◽  
And Control

scholarly journals Prevention and Control of American Foulbrood in South America with Essential Oils: Review

2020 ◽  
Author(s):  
Sandra Rosa Fuselli ◽  
Pablo Gimenez Martinez ◽  
Giselle Fuentes ◽  
Rosa María Alonso-Salces ◽  
Matías Maggi
Keyword(s):  
South America ◽  
Essential Oils ◽  
Prevention And Control ◽  
American Foulbrood ◽  
And Control

Prevention and control of Hepatitis A in developing nations: Public health perspective

2017 ◽  
Vol 10 (5) ◽  
pp. 1382
Author(s):  
SaurabhR Shrivastava ◽  
PrateekS Shrivastava ◽  
Jegadeesh Ramasamy
Keyword(s):  
Public Health ◽  
Prevention And Control ◽  
Hepatitis A ◽  
Developing Nations ◽  
Public Health Perspective ◽  
And Control

Linking decision-making research and cancer prevention and control: Important themes.

2005 ◽  
Vol 24 (4, Suppl) ◽  
pp. S106-S110 ◽  
Author(s):  
Kevin D. McCaul ◽  
Ellen Peters ◽  
Wendy Nelson ◽  
Michael Stefanek
Keyword(s):  
Decision Making ◽  
Cancer Prevention ◽  
Prevention And Control ◽  
Cancer Prevention And Control ◽  
And Control
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