Risk Assessment of Future Type 2 Diabetes and Implication for Prevention

2018 ◽  
pp. 207-215
Author(s):  
Pietro Amedeo Modesti ◽  
Maria Calabrese ◽  
Giorgio Galanti
Keyword(s):  
Type 2 Diabetes ◽  
Risk Assessment

Risk assessment of adult residents in ile-ife, South-Western Nigeria for type 2 diabetes mellitus

2013 ◽  
pp. 1-1
Author(s):  
Gbadebo Ajani ◽  
Rosemary Ikem ◽  
Adenike Enikuomehin ◽  
David Soyoye ◽  
Babatope Kolawole
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Risk Assessment ◽  
Type 2 Diabetes Mellitus

scholarly journals Early vascular aging risk assessment in patients with metabolic syndrome

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
A Salasyuk ◽  
S Nedogoda ◽  
I Barykina ◽  
V Lutova ◽  
E Popova
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Risk Assessment ◽  
Metabolic Syndrome ◽  
Vascular Aging ◽  
Clinical Markers ◽  
Cvd Risk ◽  
Vascular Age

Abstract Background Metabolic syndrome (MetS) and abdominal obesity are one of the most common CVD risk factors among young and mature patients. However, the currently used CVD risk assessment scales may underestimate the CV risk in people with obesity and MS. Early vascular aging rather than chronological aging can conceptually offer better risk prediction. MetS, as accumulation of classical risk factors, leads to acceleration of early vascular aging. Since an important feature of MetS is its reversibility, an adequate risk assessment and early start of therapy is important in relation to the possibilities of preventing related complications. Purpose To derive a new score for calculation vascular age and predicting EVA in patients with MetS. Methods Prospective open cohort study using routinely collected data from general practice. The derivation cohort consisted of 1000 patients, aged 35–80 years with MetS (IDF,2005 criteria). The validation cohort consisted of 484 patients with MetS and carotid-femoral pulse wave velocity (cfPWV) values exceeding expected for average age values by 2 or more SD (EVA syndrome). Results In univariate analysis, EVA was significantly correlated with the presence of type 2 diabetes and clinical markers of insulin resistance (IR), body mass index (BMI), metabolic syndrome severity score (MetS z-score), uric acid (UA) level, hsCRP, HOMA-IR, total cholesterol (TC), triglycerides (TG), heart rate (HR), central aortic blood pressure (CBP), diastolic blood pressure (DBP). Multiple logistic regression shown, that presence of type 2 diabetes and IR were associated with greater risk of EVA; the odds ratios were 2.75 (95% CI: 2.34, 3.35) and 1.57 (95% CI: 1.16, 2.00), respectively. In addition, the risk of having EVA increased by 76% with an increase in HOMA-IR by 1 unit, by 17% with an increase in hsCRP by 1 mg/l, by 4% with an increase in DBP by 1 mm Hg, and by 1% with each 1 μmol / L increase in the level of UA. The area under the curve for predicting EVA in patients with MetS was 0,949 (95% CI 0,936 to 0,963), 0,630 (95% CI 0,589 to 0,671), 0,697 (95% CI 0,659 to 0,736) and 0,686 (95% CI 0,647 to 0,726), for vascular age, calculated from cfPWV, SCORE scale, QRISK-3 scale and Framingham scale, respectively. Diabetes mellitus and clinical markers of IR (yes/no), HOMA-IR and UA level were used to develop a new VAmets score for EVA prediction providing a total accuracy of 0.830 (95% CI 0,799 to 0,860). Conclusion cfPWV at present the most widely studied index of arterial stiffness, fulfills most of the stringent criteria for a clinically useful biomarker of EVA in patients with MetS. Although, parallel efforts for effective integration simple clinical score into clinical practice have been offered. Our score (VAmets) may accurately identify patients with MetS and EVA on the basis of widely available clinical variables and classic cardiovascular risk factors can prioritize using of vascular age in routine care. ROC-curves for predicting EVA in MetS Funding Acknowledgement Type of funding source: None

scholarly journals Natriuretic peptides and risk of type 2 diabetes: Results from the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) Consortium

2021 ◽  
Author(s):  
Chaterina Sujana ◽  
Veikko Salomaa ◽  
Frank Kee ◽  
Simona Costanzo ◽  
Stefan Söderberg ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Risk Assessment ◽  
Cardiovascular Risk ◽  
Inverse Association ◽  
Cardiovascular Risk Assessment ◽  
Multiplicative Interaction ◽  
Incident Type ◽  
Incident Type 2 Diabetes

<p><b>Objective: </b>Natriuretic peptide (NP) concentrations are increased in cardiovascular diseases (CVD) but are associated with a lower diabetes risk. We investigated associations of N-terminal pro-B-type NP (NT-proBNP) and mid-regional pro-atrial NP (MR-proANP) with incident type 2 diabetes stratified by the presence of CVD. </p> <p><b> </b></p> <p><b>Research Design and Methods:</b> Based on the Biomarkers for Cardiovascular Risk Assessment in Europe-(BiomarCaRE) Consortium, we included 45,477 participants with NT-proBNP measurements (1,707 developed type 2 diabetes over 6.5 years of median follow-up; among these, 209 had CVD at baseline) and 11,537 participants with MR-proANP measurements (857 developed type 2 diabetes over 13.8 years of median follow-up; among these, 106 had CVD at baseline). The associations were estimated using multivariable Cox regression models. </p> <p> </p> <p><b>Results: </b>Both NPs were inversely associated with incident type 2 diabetes (hazard ratios [95%CI] per 1-standard deviation increase of log NP: 0.84 [0.79; 0.89] for NT-proBNP and 0.77 [0.71; 0.83] for MR-proANP). The inverse association between NT-proBNP and type 2 diabetes was significant in individuals without, but not in individuals with CVD (0.81 [0.76; 0.86] vs 1.04 [0.90; 1.19]; <i>P</i>-multiplicative interaction= 0.001). There was no significant difference in the association of MR-proANP with type 2 diabetes between individuals without and with CVD (0.75 [0.69; 0.82] vs 0.81 [0.66; 0.99]; <i>P</i>-multiplicative interaction= 0.236). </p> <p> </p> <p><b>Conclusions:</b> NT-proBNP and MR-proANP are inversely associated with incident type 2 diabetes. However, the inverse association of NT-proBNP seems to be modified by the presence of CVD. Further investigations are warranted to confirm our findings and to investigate the underlying mechanisms.</p>

Comparison of IDRS and ADA Diabetes Risk Assessment Tools Reveals Different Rsk Score in Same Population: A Cross-Sectional Analysis in a Tertiary Care Hospital

2021 ◽  
Vol 5 (1) ◽  
pp. 10-18
Author(s):  
N. Akter ◽  
N.K. Qureshi
Keyword(s):  
Type 2 Diabetes ◽  
Risk Assessment ◽  
High Risk ◽  
Risk Score ◽  
Diabetes Risk ◽  
Assessment Tools ◽  
Cross Sectional ◽  
Risk Assessment Tools ◽  
Predicted Risk

Background: To identify individuals at high risk of developing type2 diabetes (T2DM), use of a validated risk-assessment tool is currently recommended. Nevertheless, recent studies have shown that risk scores that are developed in the same country can lead to different results of an individual. The Objective of study was to reveal whether two different risk-assessment tools predict similar or dissimilar high-risk score in same population. Method: This cross-sectional analytical study was carried upon 336 non-diabetic adults visiting the outpatient department (OPD) of Medicine, MARKS Medical College & Hospital, Bangladesh from October 2018 to March 2019. Woman having previous history of Gestational Diabetes Mellitus (GDM) were also included. Both the Indian Diabetes risk Score (IDRS) and the American Diabetes (ADA) Risk Score questionnaire were used to collect the data on demographic and clinical characteristics, different risk factors of an individual subject, and to calculate predicted risk score for developing T2DM. Results: Among 336 subjects, 53.6% were female. The mean (±SD) age of the study subjects was 38.25±1.12 years. The average IDRS predicted risk score of developing T2DM was more in female subjects than male [p<0.05]. Whereas the ADA predicted increased risk score of developing type 2 diabetes was more in male subjects than female (p<0.05). IDRS categorized 37.2 % of individuals at high risk for developing diabetes; [p=0.10], while the ADA risk tool categorized 20.2% subjects in high risk group; [p<0.001]. Conclusions: The results indicate that risk for developing type 2 diabetes varies considerably according to the scoring system used. To adequately prevent T2DM, risk scoring systems must be validated for each population considered.

A Descriptive Study to Assess the Risk of Stroke among Patients with Hypertension and Type 2 Diabetes Mellitus at a Selected Hospital, Bangalore

2021 ◽  
Vol 6 (3) ◽  
pp. 407-412
Author(s):  
Leena Dorothy W ◽  
Pavithra C ◽  
Umadevi A K
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Risk Assessment ◽  
Type 2 Diabetes Mellitus ◽  
Stroke Risk ◽  
Family Type ◽  
Survey Method ◽  
Risk Category

Objective: Stroke is a major public health problem, both in developed and developing countries. Stroke is becoming an important cause of early death and disability in India due to increasing prevalence of the major key modifiable risk factors like type 2 diabetes mellitus and hypertension. Hence there is an urgent need for recognition of stroke risk factors and its warning signs. With this intention the present study aimed to assess the risk of stroke among patients with hypertension and type 2 diabetes mellitus. Methods: A non-experimental, descriptive survey method was adopted. Samples were selected by using quota sampling technique and 60 hypertensive and type 2 diabetes mellitus patients who met the inclusion criteria were selected for the study. Data were collected by an interview technique using a modified stroke risk assessment tool by the National Stroke Association, USA. Results: Out of 60 samples 48.3% of them were in high-risk category, 28.3% were in caution and 23.3% in low-risk category. There was a significant association found in relation to socio demographic variables such as education qualification, type of family, type of diet, weight and complications of hypertension (P<0.05). Discussion: The findings of the study suggested that there is an increased risk of stroke in hypertension and type 2 diabetes patients which can be aggravated by other risk factors and co-morbid conditions. Hence modifying these risk factors by changing lifestyle can help in prevention of stroke. Keywords: Stroke, risk assessment, hypertension and type 2 diabetes mellitus, comorbid conditions.

CP-009 Risk assessment of diabetes ketoacidosis in type 2 diabetes mellitus patients treated with sodium–glucose cotransporter type 2 inhibitors

2017 ◽  
Author(s):  
D Blanquez Martinez ◽  
M Hayon Ponce ◽  
A Caballero Romero ◽  
X Diaz Villamarin ◽  
MDC Gonzalez Medina ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Risk Assessment ◽  
Type 2 Diabetes Mellitus ◽  
Sodium Glucose Cotransporter
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