Management of Glial Tumor Recurrence

2018 ◽  
pp. 281-291
Author(s):  
Konstantinos N. Fountas ◽  
Eftychia Z. Kapsalaki
Keyword(s):  
Tumor Recurrence ◽  
Glial Tumor

scholarly journals The Value of Magnetic Resonance in Differentiation between Brain Glioma and Treatment Induced Injury

2012 ◽  
Vol 12 (1) ◽  
pp. 24-28
Author(s):  
Anvita Bieza ◽  
Gaida Krumina
Keyword(s):  
Magnetic Resonance ◽  
Signal Intensity ◽  
Tumor Recurrence ◽  
Diffusion Tensor ◽  
Combined Therapy ◽  
Resonance Spectroscopy ◽  
Glial Tumor ◽  
Magnetic Resonance Imaging Mri ◽  
Induced Changes ◽  
Brain Gliomas

SummaryIntroduction.The further therapeutic management decisions in glioma patients after the radiation/chemotherapy may be difficult because the treatment induced brain injury can mimic tumor recurrence clinically and on neuroimaging.Aim of the Studywas to assess the usefulness of magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI) in differentiation between glial tumor recurrence and radiation/chemotherapy-induced changes in the brain.Material and methods.73 patients with primary brain gliomas and 77 gliomas patients after combined therapy with possibly treatment induced changes underwent MRS and DTI. Fractional anisotropy (FA) and metabolite ratios were measured in the tumor and pathological signal intensity area adjacent to post-surgical cavity.Results.Mean choline/creatine (Cho/Cr), myoinositol/creatine (MI/Cr), lactate-lipid/creatine (LL/Cr) ratios of brain gliomas was statistically significant higher and FA values lower than those in the pathological signal intensity area adjacent to post-surgical cavity. No differences were found in mean N-acetyl aspartate/creatine (NAA/Cr) ratios among two groups.Conclusions.Our study suggests that Cho/Cr, MI/Cr, LL/Cr and FA measures should be recommended as additional highly informative tool to conventional structural magnetic resonance imaging (MRI) when monitoring gliomas patients after combined therapy.

scholarly journals The High-Grade Glial Component Of Pediatric Primary Anaplastic Ganglioglioma Characterized Astroblastoma-Like Pseudorosettes With BRAFV600E Mutation And Deletion Of CDKN2A/B, PTEN, And BMPR1A: A Case Report

2021 ◽  
Author(s):  
Duan Zejun ◽  
Yao Kun ◽  
Feng Jing ◽  
Qi Xueling
Keyword(s):  
Tumor Recurrence ◽  
Ganglion Cells ◽  
Minor Component ◽  
High Grade Glioma ◽  
Adjuvant Chemoradiotherapy ◽  
Mitotic Figure ◽  
Low Grade ◽  
High Grade ◽  
Glial Tumor ◽  
Short Period

Abstract Background: Ganglioglioma (GG) is a low-grade mixed neuronal-glial tumor which is the most common type of long-term epilepsy-associated tumors (LEATs). However, primary anaplastic ganglioglioma (AGG) which composes of malignant changes is rare. Here, we report a case of pediatric primary AGG which is consisted of low-grade/begnin GG and high-grade glioma that was characterized by astroblastoma-like pseudorosettes. Case presentation: We describe a case of 4-year-old female who presented with medically refractory seizure for 14 months by a temporal mass. The patient underwent a gross total mass resection at the first surgery, and was only treated with antiepileptic therapy and followed by observation. After nine months, tumor recurrence was found. Followed by second operation, the patient was treated with chemotherapy (oral temozolomide and antiepileptic drugs) and local radiotherapy. At 58-month follow-up after the second operation, no epileptic seizures and tumor recurrence were found again. In the first sample, the tumor contained two different components. The major component presented the low-grade GG’s features of neoplastic glial cells and dysplastic ganglion cells. The minor component was a heterogeneous high-grade glioma characterized astroblastic-like pseudorosettes clusters with increased mitotic figure (about 4-6 per 10 high-power fields). CD34 staining was negative. BRAFV600E was positive in both components. In the recurrent sample, the heterogeneous high-grade glioma became the major component. The fuorescence in situ hybridization (FISH) of MN1 break-apart probe and MYB–QKI fusions probe were negative. BRAFV600E mutation, and deletion of CDKN2A/B, PTEN and BMPR1A were detected by targeted DNA sequencing. Conclusion: This case extends the histomorphologic spectrum and enriched genetic features of primary AGG in childhood. The high-grade glioma charactered astroblastoma-like pseudorosettes may be an important cause of tumor recurrence in a short period of time. Tumor gross total surgical resection and adjuvant chemoradiotherapy were important to achive an event-free survival.

918: B7-H1 Expression Predicts Tumor Recurrence in Patients with Favorable Histology Wilms’ Tumor

2007 ◽  
Vol 177 (4S) ◽  
pp. 304-305
Author(s):  
Jonathan C. Routh ◽  
Richard A. Ashley ◽  
Thomas J. Sebo ◽  
Christine M. Lohse ◽  
Douglas A. Husmann ◽  
...  
Keyword(s):  
Tumor Recurrence ◽  
Wilms Tumor ◽  
Favorable Histology

Free T4/Thyroglobulin Ratio Predicts Tumor Recurrence Risk

2007 ◽  
Vol 2 (11) ◽  
pp. 27
Author(s):  
MICHELE G. SULLIVAN
Keyword(s):  
Tumor Recurrence ◽  
Recurrence Risk ◽  
Free T4

IS ENDOBILIARY STENTING A CULPRIT FOR TUMOR RECURRENCE IN AMPULLARY CARCINOMA?

2020 ◽  
Author(s):  
SB Kim ◽  
MC Kim ◽  
MG Kang ◽  
JH Cho ◽  
JG Park ◽  
...  
Keyword(s):  
Tumor Recurrence ◽  
Ampullary Carcinoma

SPECT Thallium Imaging in Meningiomas: Early Functional Indications in Neovascularity and Tumor Recurrence

Skull Base ◽  
2007 ◽  
Vol 17 (S 1) ◽  
Author(s):  
Raj Shrivastava ◽  
Jonathan Lesser ◽  
Munir Ghesani ◽  
Chandranath Sen
Keyword(s):  
Tumor Recurrence ◽  
Thallium Imaging

Does growth hormone therapy increase the frequency of tumor recurrence in children with brain tumors?

1987 ◽  
Vol 116 (3_Suppl) ◽  
pp. S188-S189 ◽  
Author(s):  
K.P. RODENS ◽  
S.L. KAPLAN ◽  
M.M. GRUMBACH ◽  
W.M. TELLER
Keyword(s):  
Growth Hormone ◽  
Brain Tumors ◽  
Hormone Therapy ◽  
Tumor Recurrence ◽  
Growth Hormone Therapy
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