Intraoperative Pathological Examination of Breast Lesions

Breast Cancer ◽  
2018 ◽  
pp. 163-170
Author(s):  
Ekrem Yavuz ◽  
Sitki Tuzlali
Keyword(s):  
Pathological Examination ◽  
Breast Lesions

Accurate excision of nonpalpable breast lesions with the new device system.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e11557-e11557
Author(s):  
Zhongyao Luo
Keyword(s):  
Breast Tissue ◽  
Breast Biopsy ◽  
Low Cost ◽  
Pathological Examination ◽  
Breast Lesions ◽  
Localization Method ◽  
Needle Localization ◽  
New Device ◽  
Small Nodule ◽  
Nonpalpable Breast Lesions

e11557 Background: A histological diagnosis for nonpalpable breast lesions (NPBL) is required to determine suitable therapy. The open-breast biopsy (OBB) is the gold standard to determine the nature of NPBL. However, it is not easy to accurately remove whole breast lesions due to insufficient safe margin of lesions excised. To improve accuracy for removal of NPBL, we designed new tools to assist surgeons to accurately localize and remove NPBL during OBB. Methods: The new device system has two primary parts. First is a set of accurate-resection devices composed of a rotary cutter, a pair of inner and outer tubes, two pairs of concave and convex curved hooks, and a curved incision plate. The second part is the 12 o'clock localization method used to accurately position lesions three-dimensionally after the breast tissue is excised cylindrically. Thus, the exact location of breast lesions removed can be precisely traced back to the original breast tissue location. Results: 100 patients with a total of 149 OBB were studied using the new device system guided with needle localization under ultrasound. 112 out of 149 procedures were identified as nodule. Among 112 cases, 95 were breast fibroadenomas, 10 were mammary adenosis with a trend to form fibroadenoma, 5 were mammary adenosis, and 2 were adipomas. The remaining 37 cases possessed clusters of calcified lesions with small nodule. 32 were benign lesions with calcinosis, and the other 5 lesions were identified as breast cancer. Pathological examination demonstrated that 144 NPBL were accurately resected with accurate-resection devices. However, 19 out of 144 breast lesions were not completely removed the first time. Thus the second surgical procedure was performed for the 19 cases based on 12 o'clock localization method. The results demonstrated that the remaining lesions were accurately and completely eliminated with the second procedure. All patients were followed up with for 2 to 48 months post procedures. These patients treated with accurate resection devices were very satisfied with no breast deformation. Conclusions: The new device system is easy to use and has very low cost. It is very comfortable for the patient and is of great help in accurately localizing and resecting the lesions to the surgeon.

scholarly journals Diagnostic Value of Virtual Touch Tissue Quantification for Breast Lesions with Different Size

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Minghua Yao ◽  
Jian Wu ◽  
Liling Zou ◽  
Guang Xu ◽  
Juan Xie ◽  
...  
Keyword(s):  
Characteristic Curve ◽  
Diagnostic Value ◽  
Lesion Size ◽  
Normal Breast ◽  
Pathological Examination ◽  
Breast Lesions ◽  
Virtual Touch Tissue Quantification ◽  
Significant Difference ◽  
The Difference ◽  
Tissue Quantification

Purpose. To evaluate diagnostic value of the virtual touch tissue quantification (VTTQ) for breast lesions with different sizes.Materials and Methods. Patients with 206 breast lesions were categorized into three groups according to lesion size (<10 mm, 10–20 mm, and >20 mm). Breast lesions were examined by conventional ultrasound and VTTQ, and shear wave velocity (SWV) of each lesion and adjacent normal breast tissue were measured. Diagnoses were confirmed by pathological examination after surgery. The receiver-operating characteristic curve (ROC) analyses were performed to evaluate the diagnostic value of SWV, and the area under curves (AUC) was compared among groups.Results. SWV of malignant lesions was much higher than that of benign lesions, whereas the difference was not obvious for lesions <10 mm (P=0.15). There was statistical significant difference of AUC between lesions <10 mm and 10–20 mm (P<0.05), as well as lesions <10 mm and >20 mm (P<0.05). The sensitivity of lesions <10 mm was 33.33%, which was relatively low compared to other groups.Conclusion. According to our results, VTTQ is a promising method for breast lesions >10 mm, and further studies were warranted to improve sensitivity of VTTQ for breast lesions <10 mm.

scholarly journals The value of peri-lesional tissue stiffness and stiff rim sign in the differential diagnosis between benign and malignant breast lesions

2019 ◽  
Author(s):  
wen-tao Kong ◽  
yin Wang ◽  
wei-jun Zhou ◽  
yi-dang Zhang ◽  
xiao-ming Zhuang ◽  
...  
Keyword(s):  
Shear Wave ◽  
Diagnostic Performance ◽  
Breast Lesion ◽  
Elasticity Modulus ◽  
Shear Wave Elastography ◽  
Surrounding Tissue ◽  
Pathological Examination ◽  
Breast Lesions ◽  
Tissue Stiffness ◽  
Malignant Lesions

Abstract Background Shear wave elastography (SWE) is an important method in the diagnosis of breast lesions. The purpose of this study was to evaluate the value of tissue stiffness around breast lesion and stiff rim sign for the differentiation of benign and malignant lesions. Methods 192 patients (mean age, 44.6 ± 13.6 years) with 199 breast lesions proven by pathological examination underwent shear wave elastography (SWE). We first observed if there was a stiff rim sign. Then the shell around the breast lesion on SWE was automatically drawn by machine, with width of 1mm, 2mm and 3mm. Elasticity modulus of the lesion and surrounding tissue were recorded, including maximum elasticity (Emax), mean elasticity (Emean), minimum elasticity (Emin) and elasticity ratio (shell/lesion ratio). The optimal thresholds of elasticity modulus were calculated according to receiver operating characteristic (ROC) curve. Results There were 75 malignant lesions and 124 benign lesions. The average Emax, Emean of lesion and shell were significantly higher in the malignant group than in the benign group (P<0.05). The optimal cut-off value of Emax for diagnosing malignant lesion was 101.7 Kpa, with a sensitivity of 66.3% and specificity of 87.9%. The optimal cut-off value of Emean was 29.1 Kpa, with a sensitivity of 65.3% and specificity of 79.8%. The stiff rim sign had a highest diagnostic performance for malignancy than other elastic parameters, with an accuracy of 88.4%. However, measuring peritumoral tissue stiffness can achieve a relatively high sensitivity, whereas specificity was not improved significantly. Conclusion The stiffness of tissue surrounding breast malignancy was significantly higher than benign lesion. Stiff rim sign has the potential to improve the diagnostic performance of breast lesions.

scholarly journals PROPORTIONS OF VARIOUS BENIGN BREAST LESIONS AMONG WOMEN PRESENTING AT TERTIARY CARE INSTITUTE OF INDIA: A CROSS-SECTIONAL STUDY

2021 ◽  
Vol 5 (10) ◽  
Author(s):  
Manish R. Malani
Keyword(s):  
Tertiary Care ◽  
Phyllodes Tumor ◽  
Pathological Examination ◽  
Breast Diseases ◽  
Breast Lesions ◽  
Breast Abscess ◽  
Fibrocystic Disease ◽  
Benign Breast Diseases ◽  
Care Institute ◽  
Benign Breast Lesions

Background and Aim: Benign Breast Diseases (BBDs) is a group of non-cancerous breast diseases. A triple assessment which is done by a clinical examination, imaging like ultrasonography (USG) or mammography and a pathological examination – FNAC or core needle biopsy, during the initial consultation, allows clinicians to give immediate reassurance to most of the patients. The aim of the study was to find out the proportions of various benign breast lesions among women aged 18 years and above. Material and Methods: A prospective study was conducted in the Department of Surgery, Tertiary care institute of India for a period of 20 Months. Based on the pilot study sample size derived was found to be 102. A performa was filled with patient particulars, history and clinical findings in female patient attending department of surgery OPD with breast related symptoms. Patients will be followed up with histopathological, cytological and radiological studies in indicated cases. The patients will be followed up for 1 year. Most common benign breast related symptoms and condition among the study group and probable risk factors for the same will be analyzed. Results:The commonest case among the study population was fibroadenoma 37 (36.27%). The next common was acute breast abscess, followed by fibrocystic disease (9). Lump alone detected either by patient herself or by the clinician was the most common presenting complaint in around 40 patients, followed by lump with pain in around 37, followed by either pain, nipple discharge. Fibroadenoma could be diagnosed clinically with an accuracy of about 89%. Abscess breast, phyllodes tumor and galactocele and few cases of granulomatous mastitis was also able to be diagnosed clinically. Conclusion: Fibrocystic disease is commonest amongst proliferative breast lesions followed by Sclerosing adenosis. Breast abscess is the commonest lesion amongst inflammatory breast lesions. Breast self-examination and health education to females is very important in cases of benign proliferative lesions. Key Words: Benign Breast Diseases, Fibroadenoma, Phyllodes tumor, Ultrasonography

scholarly journals Phyllodic tumors of the breast: Frequency and anatomo-histoclinical aspects at Conakry University Teaching Hospital (CHU). Guinea

2021 ◽  
Vol 2 (1) ◽  
pp. 001-006
Author(s):  
Boubacar siddi Diallo ◽  
Boubacar alpha Diallo ◽  
Ibrahima conte ◽  
Abdoulaye sylla ◽  
Diallo yaya ◽  
...  
Keyword(s):  
Teaching Hospital ◽  
Benign Tumor ◽  
Histological Grade ◽  
University Teaching ◽  
Pathological Examination ◽  
Breast Lesions ◽  
Phyllodes Tumors ◽  
Study Results ◽  
Phyllodes Tumours ◽  
Associated Consistency

Objectives: Calculate the frequency of phyllodes tumors of the breast, describe the epidemiological profile and describe the anatomo-histoclinical aspects of phyllodes tumors of the breast at the Conakry University Teaching Hospital. Methodology: This was a retrospective descriptive type study lasting 10 years, from January 1, 2008 to December 31, 2018. It concerned all cases of breast lesions, the parts that were examined in the anatomo-pathological laboratory. All cases of mammary tumours were included for the diagnosis of phyllodes tumor which was histologically confirmed. All cases of breast lesions for which the diagnosis was histologically ruled out were excluded. We carried out an exhaustive examination of the data available in the registers of the anatomo-pathologies service of the Conakry University Teaching Hospital. . The limitations or constraints of the study were the absence of certain information on the pathological examination request forms and the absence of an immunohistochemical study. Results: The frequency of phyllodes tumors was 02.72% (n = 22) among benign and malignant breast pathologies (n = 807) and 1.65% among those of genital and breast pathologies (n = 1334). The epidemiologic profile was that of a woman in the age group 50-59 (27.27%), nulliparous (45.45%). Inflammation was the main reason for consultation (100%). The main presumptive clinical diagnosis was benign tumor (54.54%). Lumpectomy was the main surgical procedure (36.36%) followed by excised biopsies (27.27%). Cases of phyllodes with a consistency firm were the most observed (50%) followed by cases with associated consistency 6 cases (27.27%). Phyllodes tumours without rearrangements represented (63.63%) followed by cases with associated rearrangements (13.63%). Grade I constituted the majority of the histological grade found (54.54%) followed by grade II (22.73%). Phyllodes tumors with benign behavior constituted the majority of cases observed 17 (77.27%). Tumors resected in a healthy zone were the most represented (72.73%). The histologic types with good prognosis constituted the majority of our diagnosed cases (77.27%). Conclusion: Phyllodes tumours constitute of a particular histological type of fibroepithelial tumours of the breast. They constitute a predominantly benign tumor, its malignant forms consist of high-grade sarcomas, often with a poor prognosis. They affect all ages, but especially women between the third and fifth decade. Their diagnosis is exclusively histological, which makes it possible to assess to their behavior, grade and histological prognosis

scholarly journals Bilateral Simultaneous Pseudoangiomatous Stromal Hyperplasia of the Breasts and Axillae: Imaging Findings with Pathological and Clinical Correlation

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Afsaneh Alikhassi ◽  
Fereshteh Ensani ◽  
Ramesh Omranipour ◽  
Alireza Abdollahi
Keyword(s):  
Rare Case ◽  
Pathological Examination ◽  
Breast Lesions ◽  
Clinical Correlation ◽  
Pseudoangiomatous Stromal Hyperplasia ◽  
Breast Enlargement ◽  
Histopathological Correlation ◽  
Mri Features ◽  
Tumoral Lesion ◽  
Bilateral Breast Enlargement

Pseudoangiomatous stromal hyperplasia (PASH) of the breast is a pathology that is usually diagnosed by accident during pathological examination of other breast lesions. PASH is an uncommon and benign tumoral lesion of the mammary stroma that can be pathologically mistaken for other tumours, such as phyllodes, fibroadenoma, and sometimes even angiosarcoma. We report the case of a 45-year-old woman with complaints of huge bilateral breast enlargement. This is a rare case of PASH presenting with gigantomastia and involving bilateral breasts and axillae simultaneously. Mammography, ultrasonography, and MRI features are illustrated with histopathological correlation.

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