Tonic Pupil (Adie’s Pupil), Pharmacological Testing for

2018 ◽  
pp. 1811-1813
Author(s):  
Effie Z. Rahman ◽  
Angelina Espino Barros Palau ◽  
Michael L. Morgan ◽  
Sumayya J. Almarzouqi ◽  
Andrew G. Lee
Keyword(s):  
Tonic Pupil ◽  
Pharmacological Testing

Tonic Pupil (Adie’s Pupil), Pharmacological Testing for

2015 ◽  
pp. 1-3
Author(s):  
Effie Z. Rahman ◽  
Angela Espino Barros Palau ◽  
Michael L. Morgan ◽  
Sumayya J. Almarzouqi ◽  
Andrew G. Lee
Keyword(s):  
Tonic Pupil ◽  
Pharmacological Testing

scholarly journals Adie’s tonic pupil presenting with unilateral photophobia successfully treated with dilute pilocarpine

2020 ◽  
Vol 13 (1) ◽  
pp. e233136
Author(s):  
Hatim Batawi ◽  
Jonathan A Micieli
Keyword(s):  
Symptomatic Relief ◽  
Pharmacological Therapy ◽  
Blurred Vision ◽  
Third Nerve Palsy ◽  
Tonic Pupil ◽  
History Of ◽  
Blurry Vision ◽  
The Right ◽  
Pharmacological Testing ◽  
Left Pupil

A 40-year-old healthy man presented with a 4-month history of photophobia, blurred vision and a right dilated pupil. Examination revealed a right pupil that was not reactive to light but constricted strongly to a near target and slowly redilated when he looked back in the distance. Pharmacological testing with dilute pilocarpine 0.1% resulted in constriction of the right pupil but no change in the left pupil. This also resulted in resolution of his photophobia and blurry vision. Neurological examination was otherwise normal, and a diagnosis of Adie’s tonic pupil was made. The main differential diagnosis to consider for a large pupil is a third nerve palsy, pharmacological mydriasis, tonic pupil and local iris processes, such as iris sphincter tears from trauma. Knowledge of the key features of these conditions can avoid wasted resources from unnecessary testing. Dilute pilocarpine 0.1% three times a day can be considered as a pharmacological therapy for symptomatic relief.

Synthesis of the semi-rigid analogues of prothiadene and dithiadene as potential antidepressant and antihistamine agents: 11-[2-(Dimethylaminomethyl)cyclohexylidene]-6,11-dihydrodibenzo[b,e]thiepins and 4-[2-(dimethylaminomethyl)cyclohexylidene]-4,9-dihydrothieno-[2,3-c]-2-benzothiepins

1985 ◽  
Vol 50 (5) ◽  
pp. 1078-1088 ◽  
Author(s):  
Zdeněk Polívka ◽  
Jiří Holubek ◽  
Emil Svátek ◽  
Jan Metyš ◽  
Miroslav Protiva
Keyword(s):  
Hydrochloric Acid ◽  
Ir Spectrum ◽  
Title Compound ◽  
Dilute Hydrochloric Acid ◽  
Amino Alcohols ◽  
Geometric Isomers ◽  
Pharmacological Testing

Reaction of dibenzo[b,e]thiepin-11(6H)-one with 2-(dimethylaminomethyl)cyclohexylmagnesium chloride gave a mixture of stereoisomeric amino alcohols IX from which four homogeneous bases (IXa to IXd) were separated by chromatography. Dehydration of these compounds with boiling dilute hydrochloric acid afforded mixtures of racemic geometric isomers of the title compound VII, which were separated by crystallization. To the prevailing less polar base VIIa (E)-configuration was assigned on the basis of the IR spectrum. Using a similar procedure, thieno[2,3-c]-2-benzothiepin-4(9H)-one gave mixture of amino alcohols X from which three homogeneous stereoisomers X-A to X-C were isolated. Their dehydration resulted in both expected racemic geometric isomers VIII-A and VIII-B. Pharmacological testing proved the character of an antidepressant for the semi-rigid analogue of dithiadene VIII.

Tonic pupil, anterior ischemic optic neuropathy in a teenager with Takayasu arteritis

2013 ◽  
Vol 48 (6) ◽  
pp. e159-e163 ◽  
Author(s):  
Jyoti Matalia ◽  
Nirupama Kasturi ◽  
Hemant D. Anaspure ◽  
Bhujang K. Shetty
Keyword(s):  
Optic Neuropathy ◽  
Takayasu Arteritis ◽  
Anterior Ischemic Optic Neuropathy ◽  
Ischemic Optic Neuropathy ◽  
Tonic Pupil

THE TONIC PUPIL

The Lancet ◽  
1932 ◽  
Vol 220 (5691) ◽  
pp. 689
Keyword(s):  
Tonic Pupil

Tonic Pupil

2019 ◽  
pp. 199-204
Author(s):  
Matthew J. Thurtell ◽  
Robert L. Tomsak
Keyword(s):  
Viral Infections ◽  
Incidental Finding ◽  
Eye Drops ◽  
Sphincter Muscle ◽  
Management Options ◽  
Orbital Surgery ◽  
Fisher Syndrome ◽  
Tonic Pupil ◽  
Pupil Reaction ◽  
Characteristic Features

A tonic pupil is caused by a lesion affecting the postganglionic parasympathetic innervation of the pupil. It can be an incidental finding on examination or associated with visual symptoms, such as photophobia. In this chapter, we begin by briefly reviewing the differential diagnosis of photophobia. We next review the characteristic features of tonic pupil, which include poor pupil reaction to light, segmental palsy of the iris sphincter muscle, accommodation palsy, and tonic pupil reaction to near. We then review the causes of tonic pupil, which include viral infections, trauma, orbital surgery, or neurologic diseases, such as Miller Fisher syndrome. We then go on to discuss the clinical features, diagnostic evaluation, and prognosis of idiopathic tonic pupil, which is also known as an Adie pupil. Lastly, we briefly discuss the management options for tonic pupil, which include use of sunglasses and dilute pilocarpine eye drops.

Tonic Pupil

2011 ◽  
pp. 158-161
Author(s):  
Matthew J. Thurtell ◽  
Robert L. Tomsak ◽  
Robert B. Daroff
Keyword(s):  
Incidental Finding ◽  
Diagnostic Evaluation ◽  
Parasympathetic Innervation ◽  
Blurred Vision ◽  
Tonic Pupil ◽  
Visual Symptoms ◽  
Common Causes ◽  
The Common

A tonic pupil is caused by a lesion affecting the postganglionic parasympathetic innervation of the pupil. It can be an incidental finding on examination or associated with visual symptoms, such as photophobia or blurred vision at near. We discuss the common causes and diagnostic evaluation of a tonic pupil in this chapter.

scholarly journals Pupillary Abnormalities in Congenital Neurosyphilis

1985 ◽  
Vol 12 (2) ◽  
pp. 134-135 ◽  
Author(s):  
M.B.M. Sundaram
Keyword(s):  
Tonic Pupil

ABSTRACT:Pupils in congenital neurosyphilis differ from the classic Argyll-Robertson pupil in acquired cases, and often tend to be large and unreactive. Constriction to pilocarpine in the reported patient would suggest that peripheral parasympathetic damage is responsible for such pupillary findings. Congenital neurosyphilis should be included among the causes of “tonic” pupil.

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