Cation Channels and the Uptake of Radiocaesium by Plants

2010 ◽  
pp. 47-67 ◽  
Author(s):  
Philip J. White ◽  
Lea Wiesel ◽  
Martin R. Broadley
Keyword(s):  
Cation Channels

Cation channels of the TRPC family contribute to development of nephropathy and retinopathy in the STZ model

2015 ◽  
Vol 10 (S 01) ◽  
Author(s):  
M Freichel ◽  
D Schumacher ◽  
C Matka ◽  
I Mathar ◽  
U Kriebs ◽  
...  
Keyword(s):  
Cation Channels

The Role of TRPV4 Cation Channels in Regulation of Phenylephrine-Induced Contraction of Rat Pulmonary Artery

2017 ◽  
Vol 8 (2) ◽  
pp. 121-130
Author(s):  
Dariia Dryn ◽  
Mariia Melnyk ◽  
Ihor Kizub ◽  
Hongzhen Hu ◽  
Anatoly I. Soloviev ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
Cation Channels

Cyclopiazonic acid stimulates Ca2+ influx through non-specific cation channels in endothelial cells

1994 ◽  
Vol 251 (2-3) ◽  
pp. 119-125 ◽  
Author(s):  
He Zhang ◽  
Masato Inazu ◽  
Bryce Weir ◽  
Michael Buchanan ◽  
Ed Daniel
Keyword(s):  
Endothelial Cells ◽  
Cyclopiazonic Acid ◽  
Cation Channels

scholarly journals Endolysosomal Cation Channels and MITF in Melanocytes and Melanoma

Biomolecules ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1021
Author(s):  
Carla Abrahamian ◽  
Christian Grimm
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Transcription Factor ◽  
Convincing Evidence ◽  
Signaling Cascades ◽  
Cation Channels ◽  
Pore Channel ◽  
Different Types ◽  
Canonical Wnt ◽  
The Relationship

Microphthalmia-associated transcription factor (MITF) is the principal transcription factor regulating pivotal processes in melanoma cell development, growth, survival, proliferation, differentiation and invasion. In recent years, convincing evidence has been provided attesting key roles of endolysosomal cation channels, specifically TPCs and TRPMLs, in cancer, including breast cancer, glioblastoma, bladder cancer, hepatocellular carcinoma and melanoma. In this review, we provide a gene expression profile of these channels in different types of cancers and decipher their roles, in particular the roles of two-pore channel 2 (TPC2) and TRPML1 in melanocytes and melanoma. We specifically discuss the signaling cascades regulating MITF and the relationship between endolysosomal cation channels, MAPK, canonical Wnt/GSK3 pathways and MITF.

scholarly journals Membrane impermeant antioestrogens discriminate between ligand- and voltage-gated cation channels in NG108-15 cells

2000 ◽  
Vol 1509 (1-2) ◽  
pp. 229-236 ◽  
Author(s):  
Marcus C Allen ◽  
Pamela A Gale ◽  
A.Christy Hunter ◽  
Andrew Lloyd ◽  
Simon P Hardy
Keyword(s):  
Cation Channels ◽  
Voltage Gated

Hormones increase mRNA of cyclic-nucleotide-gated cation channels in airway epithelia

2000 ◽  
Vol 441 (1) ◽  
pp. 69-77 ◽  
Author(s):  
W. Qiu ◽  
A. Laheri ◽  
Steve Leung ◽  
S.E. Guggino
Keyword(s):  
Cyclic Nucleotide ◽  
Cation Channels ◽  
Airway Epithelia

IK1 channel activity contributes to cisplatin sensitivity of human epidermoid cancer cells

2008 ◽  
Vol 294 (6) ◽  
pp. C1398-C1406 ◽  
Author(s):  
Elbert L. Lee ◽  
Yuichi Hasegawa ◽  
Takahiro Shimizu ◽  
Yasunobu Okada
Keyword(s):  
Cancer Cells ◽  
Cellular Response ◽  
Physiological Role ◽  
Resistant Cell ◽  
Resistant Cell Line ◽  
Dominant Negative ◽  
Cation Channels ◽  
Channel Activity ◽  
Kb Cells ◽  
Induced Apoptosis

Cisplatin, a platinum-based drug, is an important weapon against many types of cancer. It induces apoptosis by forming adducts with DNA, although many aspects of its mechanism of action remain to be clarified. Previously, we found a role for the volume-sensitive, outwardly rectifying Cl− channel in cisplatin-induced apoptosis. To investigate the possibility that cation channels also have a role in the cellular response to cisplatin, we examined the activity of cation channels in cisplatin-sensitive KB-3-1 (KB) epidermoid cancer cells by the whole cell patch-clamp method. A cation channel in KB cells, activated by hypotonic stress, was identified as the Ca2+-activated, intermediate-conductance K+ (IK1) channel on the basis of its requirement for intracellular Ca2+, its blockage by the blockers clotrimazole and triarylmethane-34, and its suppression by a dominant-negative construct. Activity of this channel was not observed in KCP-4 cells, a cisplatin-resistant cell line derived from KB cells, and its molecular expression, observed by semiquantitative RT-PCR and immunostaining, appeared much reduced. Cell volume measurements confirmed a physiological role for the IK1 channel as a component of the volume-regulatory machinery in KB cells. A possible role of the IK1 channel in cisplatin-induced apoptosis was investigated. It was found that clotrimazole and triarylmethane-34 inhibited a cisplatin-induced decrease in cell viability and increase in caspase-3/7 activity, whereas 1-ethyl-2-benzimidazolinone, an activator of the channel, had the opposite effect. Thus IK1 channel activity appears to mediate, at least in part, the response of KB cells to cisplatin treatment.

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