A Model Based on Genetic Algorithm for Investigation of the Behavior of Rats in the Elevated Plus-Maze

2012 ◽  
pp. 151-158 ◽  
Author(s):  
Ariadne A. Costa ◽  
Antonio C. Roque ◽  
Silvio Morato ◽  
Renato Tinós
Keyword(s):  
Genetic Algorithm ◽  
Elevated Plus Maze ◽  
Model Based ◽  
Plus Maze ◽  
Behavior Of Rats

scholarly journals Bupropion effect depends on rats’ coping style

2019 ◽  
Vol 19 (2) ◽  
pp. 53-56
Author(s):  
Dmitry A. Zhukov ◽  
Vsevolod V. Nemez ◽  
Ekaterina P. Vinogradova
Keyword(s):  
Coping Style ◽  
Elevated Plus Maze ◽  
Coping Styles ◽  
Active Coping ◽  
Stress Disorders ◽  
Behavioral Deficits ◽  
Passive Coping ◽  
Plus Maze ◽  
Post Stress ◽  
Behavior Of Rats

Objective. The effect of antidepressant bupropion on the behavior of rats subjected to chronic mild unpredictable stress was investigated. Rats with opposite coping styles — active and passive — were subjected to stress. Materials and methods. In the population of outbred animals Wistar were isolated individuals with the opposite coping styles on the basis of the acquisition of active avoidance. The animals of these two groups were tested in the Porsolt’s test and in the elevated plus-maze, and then subjected to chronic stress. Results. Behavioral deficits were more pronounced in rats with initial active coping style. After administration of bupropion behavior in the Porsolt’s test was restored only in rats with initially active coping style. On the behavior of animals with an initially passive coping style, bupropion had no impact. Conclusion. Our findings suggest the different nature of post-stress disorders in animals with different active and passive coping styles.

scholarly journals Prolactin-releasing peptide increases rat anxiety

2021 ◽  
Vol 67 (5) ◽  
pp. 29-33
Author(s):  
D. A. Zhukov ◽  
A. G. Markov ◽  
E. P. Vinogradova
Keyword(s):  
Social Preference ◽  
Elevated Plus Maze ◽  
Preference Test ◽  
Plus Maze ◽  
The Social ◽  
The Central Nervous System ◽  
Low Levels ◽  
Prolactin Releasing Peptide ◽  
The Relationship ◽  
Behavior Of Rats

BACKGROUND: Prolactin-releasing peptide(Prl-RP), in addition to stimulating the production of prolactin, interacts with various parts of the central nervous system, participating in the implementation of many functions that are reflected in behavior.AIM: The effect of Prl-RP on the anxiety of white Wistar rats was studied since there were no data in the literature on the relationship between Prl-RP and anxiety.MATERIALS AND METHODS: Anxiety was assessed in two tests. In the elevated plus-maze (EPM), the time spent in the open arms and the number of edge reactions were recorded. In the social preference test, the time spent near a stranger, near a familiar individual, and in neutral territory were recorded.RESULTS: The administration of Prl-RP at a dose of 10-10 M with a volume of 10 µl in each nostril reduced the time spent by the animals in the open arms of the EPM, and the number of edge reactions. For testing the social interaction, animals were pre-selected for high or low levels of anxiety in the EPM. In rats with initially low levels of anxiety, Prl-RP reduced the time spent near a stranger, indicating an increase in anxiety levels. The behavior of rats with initially high levels of anxiety did not change after application of the Prl-RP.CONCLUSION: The results of our experiments indicate that the intranasal administration of Prl-RP increases the anxiety of rats.

Anxiolytic effects of ACE inhibitory peptides on the behavior of rats in an elevated plus-maze

2016 ◽  
Vol 7 (1) ◽  
pp. 491-497 ◽  
Author(s):  
Zhipeng Yu ◽  
Wenzhu Zhao ◽  
Long Ding ◽  
Yiding Yu ◽  
Jingbo Liu
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Elevated Plus Maze ◽  
Egg White ◽  
Converting Enzyme ◽  
Inhibitory Peptides ◽  
Plus Maze ◽  
Ace Inhibitory Peptides ◽  
Ace Inhibitory ◽  
Behavior Of Rats

Three novel egg white-derived peptides were demonstrated to display in vitro activities against the angiotensin converting enzyme (ACE).

Central, but not basolateral, amygdala involvement in the anxiolytic-like effects of midazolam in rats in the elevated plus maze

2010 ◽  
Vol 26 (4) ◽  
pp. 543-554 ◽  
Author(s):  
Milene C Carvalho ◽  
Caio M Moreira ◽  
Janaína M Zanoveli ◽  
Marcus L Brandão
Keyword(s):  
Basolateral Amygdala ◽  
Elevated Plus Maze ◽  
Dorsal Hippocampus ◽  
Dorsal Striatum ◽  
Input And Output ◽  
Plus Maze ◽  
Main Input ◽  
Fear And Anxiety ◽  
Behavior Of Rats

The role of the amygdala in the mediation of fear and anxiety has been extensively investigated. However, how the amygdala functions during the organization of the anxiety-like behaviors generated in the elevated plus maze (EPM) is still under investigation. The basolateral (BLA) and the central (CeA) nuclei are the main input and output stations of the amygdala. In the present study, we ethopharmacologically analyzed the behavior of rats subjected to the EPM and the tissue content of the monoamines dopamine (DA) and serotonin (5-HT) and their metabolites in the nucleus accumbens (NAc), dorsal hippocampus (DH), and dorsal striatum (DS) of animals injected with saline or midazolam (20 and 30 nmol/0.2 µL) into the BLA or CeA. Injections of midazolam into the CeA, but not BLA, caused clear anxiolytic-like effects in the EPM. These treatments did not cause significant changes in 5-HT or DA contents in the NAc, DH, or DS of animals tested in the EPM. The data suggest that the anxiolytic-like effects of midazolam in the EPM also appear to rely on GABA-benzodiazepine mechanisms in the CeA, but not BLA, and do not appear to depend on 5-HT and DA mechanisms prevalent in limbic structures.

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