scholarly journals Bupropion effect depends on rats’ coping style

2019 ◽  
Vol 19 (2) ◽  
pp. 53-56
Author(s):  
Dmitry A. Zhukov ◽  
Vsevolod V. Nemez ◽  
Ekaterina P. Vinogradova
Keyword(s):  
Coping Style ◽  
Elevated Plus Maze ◽  
Coping Styles ◽  
Active Coping ◽  
Stress Disorders ◽  
Behavioral Deficits ◽  
Passive Coping ◽  
Plus Maze ◽  
Post Stress ◽  
Behavior Of Rats

Objective. The effect of antidepressant bupropion on the behavior of rats subjected to chronic mild unpredictable stress was investigated. Rats with opposite coping styles — active and passive — were subjected to stress. Materials and methods. In the population of outbred animals Wistar were isolated individuals with the opposite coping styles on the basis of the acquisition of active avoidance. The animals of these two groups were tested in the Porsolt’s test and in the elevated plus-maze, and then subjected to chronic stress. Results. Behavioral deficits were more pronounced in rats with initial active coping style. After administration of bupropion behavior in the Porsolt’s test was restored only in rats with initially active coping style. On the behavior of animals with an initially passive coping style, bupropion had no impact. Conclusion. Our findings suggest the different nature of post-stress disorders in animals with different active and passive coping styles.

scholarly journals Psychological Resilience as a Protective Factor for Depression and Anxiety Among the Public During the Outbreak of COVID-19

2021 ◽  
Vol 11 ◽  
Author(s):  
Shasha Song ◽  
Xin Yang ◽  
Hua Yang ◽  
Ping Zhou ◽  
Hui Ma ◽  
...  
Keyword(s):  
Mental Health ◽  
Risk Factors ◽  
Coping Style ◽  
Protective Factor ◽  
Coping Styles ◽  
Active Coping ◽  
Anxiety And Depression ◽  
Psychological Resilience ◽  
Passive Coping ◽  
The Public

BackgroundPsychological resilience may reduce the impact of psychological distress to some extent. We aimed to investigate the mental health status of the public during the outbreak of coronavirus disease 2019 (COVID-19) and explore the level and related factors of anxiety and depression.MethodsFrom February 8 to March 9, 2020, 3,180 public completed the Zung’s Self-Rating Anxiety Scale (SAS) for anxiety, Zung’s Self-Rating Depression Scale (SDS) for depression, the Connor–Davidson resilience scale (CD-RISC) for psychological resilience, and the Simplified Coping Style Questionnaire (SCSQ) for the attitudes and coping styles.ResultsThe number of people with depressive symptoms (SDS > 53) was 1,303 (the rate was 41.0%). The number of people with anxiety symptoms (SAS > 50) was 1,184 (the rate was 37.2%). The depressed group and anxiety group had less education, more unmarried and younger age, as well as had significant different in SDS total score (P < 0.001), SAS total score (P < 0.001), CD-RISC total score (P < 0.001), and SCSQ score (P < 0.001). The binary logistic regression showed that female (B = -0.261, P = 0.026), strength (B = -0.079, P = 0.000), and the subscales of active coping style in SCSQ (B = -0.983, P = 0.000) remained protective factors and passive coping style (B = 0.293, P = 0.003) and higher SAS score (B = 0.175, P = 0.000) were risk factors for depression. Optimism (B = -0.041, P = 0.015) in CD-RISC was a protective factor, and passive coping styles (B = 0.483, P = 0.000) and higher SDS score (B = 0.134, P = 0.000) were risk factors for anxiety.LimitationsThis study adopted a cross-sectional design and used self-report questionnaires.ConclusionThe mental health of the public, especially females, the younger and less educational populations, and unmarried individuals, should be given more attention. Individuals with high level of mental resilience and active coping styles would have lower levels of anxiety and depression during the outbreak of COVID-19.

scholarly journals Repetitive and Inflexible Active Coping and Addiction-like Neuroplasticity in Stressed Mice of a Helplessness–Resistant Inbred Strain

2021 ◽  
Vol 11 (12) ◽  
pp. 174
Author(s):  
Simona Cabib ◽  
Paolo Campus ◽  
Emanuele Claudio Latagliata ◽  
Cristina Orsini ◽  
Valeria Tarmati
Keyword(s):  
Anxiety Disorder ◽  
Coping Strategies ◽  
Inbred Strain ◽  
Behavioral Sensitization ◽  
Coping Styles ◽  
Active Coping ◽  
Post Traumatic Stress ◽  
Coping With Stress ◽  
Temporary Reduction ◽  
Passive Coping

Dysfunctional coping styles are involved in the development, persistence, and relapse of psychiatric diseases. Passive coping with stress challenges (helplessness) is most commonly used in animal models of dysfunctional coping, although active coping strategies are associated with generalized anxiety disorder, social anxiety disorder, panic, and phobias as well as obsessive-compulsive and post-traumatic stress disorder. This paper analyzes the development of dysfunctional active coping strategies of mice of the helplessness–resistant DBA/2J (D2) inbred strain, submitted to temporary reduction in food availability in an uncontrollable and unavoidable condition. The results indicate that food-restricted D2 mice developed a stereotyped form of food anticipatory activity and dysfunctional reactive coping in novel aversive contexts and acquired inflexible and perseverant escape strategies in novel stressful situations. The evaluation of FosB/DeltaFosB immunostaining in different brain areas of food-restricted D2 mice revealed a pattern of expression typically associated with behavioral sensitization to addictive drugs and compulsivity. These results support the conclusion that an active coping style represents an endophenotype of mental disturbances characterized by perseverant and inflexible behavior.

scholarly journals Evaluation of antistress activity of Cassia auriculata seed extract

2018 ◽  
Vol 7 (2) ◽  
pp. 207-211
Author(s):  
Shravan Kumar Nanumala ◽  
◽  
B Varsha Priyanka ◽  
N Divya ◽  
S Shalini ◽  
...  
Keyword(s):  
Elevated Plus Maze ◽  
Tail Suspension Test ◽  
Seed Extract ◽  
Stress Disorders ◽  
Tail Suspension ◽  
Force Swimming Test ◽  
Cassia Auriculata ◽  
Plus Maze ◽  
Swimming Test ◽  
Suspension Test

Objective: The present study was designed to investigate the anti-stress activity of Cassia auriculata ethanolic seed extract in mice. Methodology: The anti-stress effect was evaluated by using Elevated plus maze (EPM), Force swimming test (FST) and Tail suspension test (TST). The ECS at a doses (250,500 and 1000 mg/kg p.o.) and standard (diazepam 2 mg/kg i.p and fluoxetine 20 mg/kg i.p) was administered. Results: The extract showed the increased in the number of entries and time spent in open arm in Elevated plus maze and decreased in the immobility time in both Force swimming test and Tail suspension test. Conclusion: The effect of ESC on animal behavior was concordant with a significant regulation of GABA and stress hormones. Therefore, this study was attempted to demonstrate the preventive potential of ECS against stress disorders at in vivo levels

scholarly journals Prolactin-releasing peptide increases rat anxiety

2021 ◽  
Vol 67 (5) ◽  
pp. 29-33
Author(s):  
D. A. Zhukov ◽  
A. G. Markov ◽  
E. P. Vinogradova
Keyword(s):  
Social Preference ◽  
Elevated Plus Maze ◽  
Preference Test ◽  
Plus Maze ◽  
The Social ◽  
The Central Nervous System ◽  
Low Levels ◽  
Prolactin Releasing Peptide ◽  
The Relationship ◽  
Behavior Of Rats

BACKGROUND: Prolactin-releasing peptide(Prl-RP), in addition to stimulating the production of prolactin, interacts with various parts of the central nervous system, participating in the implementation of many functions that are reflected in behavior.AIM: The effect of Prl-RP on the anxiety of white Wistar rats was studied since there were no data in the literature on the relationship between Prl-RP and anxiety.MATERIALS AND METHODS: Anxiety was assessed in two tests. In the elevated plus-maze (EPM), the time spent in the open arms and the number of edge reactions were recorded. In the social preference test, the time spent near a stranger, near a familiar individual, and in neutral territory were recorded.RESULTS: The administration of Prl-RP at a dose of 10-10 M with a volume of 10 µl in each nostril reduced the time spent by the animals in the open arms of the EPM, and the number of edge reactions. For testing the social interaction, animals were pre-selected for high or low levels of anxiety in the EPM. In rats with initially low levels of anxiety, Prl-RP reduced the time spent near a stranger, indicating an increase in anxiety levels. The behavior of rats with initially high levels of anxiety did not change after application of the Prl-RP.CONCLUSION: The results of our experiments indicate that the intranasal administration of Prl-RP increases the anxiety of rats.

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