Effect of valepotriates on the behavior of rats in the elevated plus-maze during diazepam withdrawal

1994 ◽  
Vol 260 (2-3) ◽  
pp. 233-235 ◽  
Author(s):  
Roberto Andreatini ◽  
JoséR. Leite
Keyword(s):  
Elevated Plus Maze ◽  
Plus Maze ◽  
Diazepam Withdrawal ◽  
Behavior Of Rats

scholarly journals Bupropion effect depends on rats’ coping style

2019 ◽  
Vol 19 (2) ◽  
pp. 53-56
Author(s):  
Dmitry A. Zhukov ◽  
Vsevolod V. Nemez ◽  
Ekaterina P. Vinogradova
Keyword(s):  
Coping Style ◽  
Elevated Plus Maze ◽  
Coping Styles ◽  
Active Coping ◽  
Stress Disorders ◽  
Behavioral Deficits ◽  
Passive Coping ◽  
Plus Maze ◽  
Post Stress ◽  
Behavior Of Rats

Objective. The effect of antidepressant bupropion on the behavior of rats subjected to chronic mild unpredictable stress was investigated. Rats with opposite coping styles — active and passive — were subjected to stress. Materials and methods. In the population of outbred animals Wistar were isolated individuals with the opposite coping styles on the basis of the acquisition of active avoidance. The animals of these two groups were tested in the Porsolt’s test and in the elevated plus-maze, and then subjected to chronic stress. Results. Behavioral deficits were more pronounced in rats with initial active coping style. After administration of bupropion behavior in the Porsolt’s test was restored only in rats with initially active coping style. On the behavior of animals with an initially passive coping style, bupropion had no impact. Conclusion. Our findings suggest the different nature of post-stress disorders in animals with different active and passive coping styles.

scholarly journals Prolactin-releasing peptide increases rat anxiety

2021 ◽  
Vol 67 (5) ◽  
pp. 29-33
Author(s):  
D. A. Zhukov ◽  
A. G. Markov ◽  
E. P. Vinogradova
Keyword(s):  
Social Preference ◽  
Elevated Plus Maze ◽  
Preference Test ◽  
Plus Maze ◽  
The Social ◽  
The Central Nervous System ◽  
Low Levels ◽  
Prolactin Releasing Peptide ◽  
The Relationship ◽  
Behavior Of Rats

BACKGROUND: Prolactin-releasing peptide(Prl-RP), in addition to stimulating the production of prolactin, interacts with various parts of the central nervous system, participating in the implementation of many functions that are reflected in behavior.AIM: The effect of Prl-RP on the anxiety of white Wistar rats was studied since there were no data in the literature on the relationship between Prl-RP and anxiety.MATERIALS AND METHODS: Anxiety was assessed in two tests. In the elevated plus-maze (EPM), the time spent in the open arms and the number of edge reactions were recorded. In the social preference test, the time spent near a stranger, near a familiar individual, and in neutral territory were recorded.RESULTS: The administration of Prl-RP at a dose of 10-10 M with a volume of 10 µl in each nostril reduced the time spent by the animals in the open arms of the EPM, and the number of edge reactions. For testing the social interaction, animals were pre-selected for high or low levels of anxiety in the EPM. In rats with initially low levels of anxiety, Prl-RP reduced the time spent near a stranger, indicating an increase in anxiety levels. The behavior of rats with initially high levels of anxiety did not change after application of the Prl-RP.CONCLUSION: The results of our experiments indicate that the intranasal administration of Prl-RP increases the anxiety of rats.

Anxiolytic effects of ACE inhibitory peptides on the behavior of rats in an elevated plus-maze

2016 ◽  
Vol 7 (1) ◽  
pp. 491-497 ◽  
Author(s):  
Zhipeng Yu ◽  
Wenzhu Zhao ◽  
Long Ding ◽  
Yiding Yu ◽  
Jingbo Liu
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Elevated Plus Maze ◽  
Egg White ◽  
Converting Enzyme ◽  
Inhibitory Peptides ◽  
Plus Maze ◽  
Ace Inhibitory Peptides ◽  
Ace Inhibitory ◽  
Behavior Of Rats

Three novel egg white-derived peptides were demonstrated to display in vitro activities against the angiotensin converting enzyme (ACE).

Sign in / Sign up

Export Citation Format

Share Document